Heterogeneous particle deaggregation and its implication for therapeutic aerosol performance

Journal of Pharmaceutical Sciences

Volumn 99, Issue 8, 2010, Pages 3442-3461

  Xu, Zhen ^a   Mansour, Heidi M ^a,d   Mulder, Tako ^b   McLean, Richard ^c   Langridge, John ^b   Hickey, Anthony J ^a  

^a University of North Carolina   (United States)

^b DMV Fonterra Excipients   (Germany)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d University of Kentucky   (United States)

Author keywords

Aerosolization performance; Dry powder inhaler; Fine particle fraction; Interparticulate and surface forces; Powder aerosol deaggregation equation; Shear stress; Standardized entrainment tubes; Surface heterogeneity

Indexed keywords

ADHESION; AEROSOL; DRY POWDER; FORCE; POWDER AEROSOL DEAGGREGATION EQUATION; REVIEW; SHEAR STRESS; STATISTICAL CONCEPTS; ALGORITHM; CHEMISTRY; MEDICINAL CHEMISTRY; NONLINEAR SYSTEM; PARTICLE SIZE; PARTICULATE MATTER; POWDER; STATISTICAL MODEL; THERAPEUTIC USE;

AEROSOL; DRUG CARRIER; PARTICULATE MATTER; POWDER; PROTEIN BINDING;

ADHESIVENESS; AEROSOLS; ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; MODELS, STATISTICAL; NONLINEAR DYNAMICS; PARTICLE SIZE; PARTICULATE MATTER; POWDERS; PROTEIN BINDING;

EID: 77955109860     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22057     Document Type: Review

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