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Volumn 19, Issue 1, 2006, Pages 21-27

Dry powder aerosol delivery systems: Current and future research directions

Author keywords

Computational modelling; Dry powder inhaler (DPI); In vitro performance; Lung deposition; Particle engineering; Powder formulation

Indexed keywords

DRUG; DRUG CARRIER; EXCIPIENT; GLUCOSE; LACTOSE; LEUCINE; MAGNESIUM STEARATE; MANNITOL; SALBUTAMOL SULFATE;

EID: 33645467770     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2006.19.21     Document Type: Review
Times cited : (104)

References (48)
  • 1
    • 0141740310 scopus 로고    scopus 로고
    • Inhalation drug delivery devices and emerging technologies
    • Chan, H.-K. 2003. Inhalation drug delivery devices and emerging technologies. Expert Opin. Ther. Patents 13:1333-1343.
    • (2003) Expert Opin. Ther. Patents , vol.13 , pp. 1333-1343
    • Chan, H.-K.1
  • 2
    • 0038094397 scopus 로고    scopus 로고
    • Novel alternative methods for the delivery of drugs for asthma treatment
    • Chan, H.-K. and N. Chew. 2003. Novel alternative methods for the delivery of drugs for asthma treatment. Adv. Drug Deliv. Rev. 55:793-805.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 793-805
    • Chan, H.-K.1    Chew, N.2
  • 3
    • 0346352236 scopus 로고    scopus 로고
    • Pulmonary delivery of novel insulin microspheres
    • Davis Horwood International, Tucson
    • Brown, L.R., J. Rashba-Step, T. Scott, et al. 2002. Pulmonary Delivery of Novel Insulin Microspheres. in Respiratory Drug Delivery VIII. Davis Horwood International, Tucson.
    • (2002) Respiratory Drug Delivery VIII
    • Brown, L.R.1    Rashba-Step, J.2    Scott, T.3
  • 4
    • 33645470195 scopus 로고    scopus 로고
    • 2002. A process and apparatus for preparing nanoparticle compositions with amphiphilic copolymers. International Patent Publication WO2002078674
    • Johnson, B.K., and R.K. Prud'homme. 2002. A process and apparatus for preparing nanoparticle compositions with amphiphilic copolymers. International Patent Publication WO2002078674.
    • Johnson, B.K.1    Prud'homme, R.K.2
  • 5
    • 0141848427 scopus 로고    scopus 로고
    • Chemical processing and micromixing in confined impinging jets
    • Johnson, B.K. and R.K. Prud'homme. 2003. Chemical processing and micromixing in confined impinging jets. AIChE J. 49:2264-2282.
    • (2003) AIChE J. , vol.49 , pp. 2264-2282
    • Johnson, B.K.1    Prud'homme, R.K.2
  • 6
    • 0030148294 scopus 로고    scopus 로고
    • Interaction of macro- and micro-mixing on particle size distribution in reaction precipitation
    • Chen, J.-F., C. Zheng, and G.T. Chen. 1996. Interaction of macro- and micro-mixing on particle size distribution in reaction precipitation. Chem. Eng. Sci. 51:1957-1966.
    • (1996) Chem. Eng. Sci. , vol.51 , pp. 1957-1966
    • Chen, J.-F.1    Zheng, C.2    Chen, G.T.3
  • 7
    • 0034110573 scopus 로고    scopus 로고
    • Synthesis of nanoparticles with novel technology: High-gravity reactive precipitation
    • Chen, J.F., Y.H. Wang, F. Guo, et al. 2000. Synthesis of nanoparticles with novel technology: high-gravity reactive precipitation. Ind. Eng. Chem. Res. 39:948-954.
    • (2000) Ind. Eng. Chem. Res. , vol.39 , pp. 948-954
    • Chen, J.F.1    Wang, Y.H.2    Guo, F.3
  • 8
    • 0348048800 scopus 로고    scopus 로고
    • Feasibility of preparing nanodrugs by high-gravity reactive precipitation
    • Chen, J.-F., M.-Y. Zhou, L. Shao, et al. 2004. Feasibility of preparing nanodrugs by high-gravity reactive precipitation. Int. J. Pharm. 269:267-274.
    • (2004) Int. J. Pharm. , vol.269 , pp. 267-274
    • Chen, J.-F.1    Zhou, M.-Y.2    Shao, L.3
  • 9
    • 0024865698 scopus 로고
    • Aerodynamic properties of a solid form of cromoglycic acid
    • Chan, H.-K. and I. Gonda. 1989. Aerodynamic properties of a solid form of cromoglycic acid. J. Aerosol Sci. 20:157-168.
    • (1989) J. Aerosol Sci. , vol.20 , pp. 157-168
    • Chan, H.-K.1    Gonda, I.2
  • 10
    • 9644255612 scopus 로고    scopus 로고
    • Prediction of aerodynamic diameter of particles with rough surfaces
    • Tang, P., H.-K. Chan, and J. Raper. 2004. Prediction of aerodynamic diameter of particles with rough surfaces. Powder Technol. 147:64-78.
    • (2004) Powder Technol. , vol.147 , pp. 64-78
    • Tang, P.1    Chan, H.-K.2    Raper, J.3
  • 11
    • 0037724040 scopus 로고    scopus 로고
    • Limitation of determination of surface fractal dimension using N2 absorption isotherms and modified Frenkel-Halsey-Hill theory
    • Tang, P., N. Chew, H.-K. Chan, et al. 2003. Limitation of determination of surface fractal dimension using N2 absorption isotherms and modified Frenkel-Halsey-Hill theory. Langmuir 19:2632-2638.
    • (2003) Langmuir , vol.19 , pp. 2632-2638
    • Tang, P.1    Chew, N.2    Chan, H.-K.3
  • 12
    • 17644394959 scopus 로고    scopus 로고
    • How much particle surface corrugation is sufficient to improve aerosol performance of powders?
    • Chew, N.Y.K., P. Tang, H.-K. Chan, et al. 2005. How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharm. Res. 22:147-151.
    • (2005) Pharm. Res. , vol.22 , pp. 147-151
    • Chew, N.Y.K.1    Tang, P.2    Chan, H.-K.3
  • 13
    • 0034858772 scopus 로고    scopus 로고
    • Characterization of two polymorphe of salmeterol xinafoate crystallized from supercritcal fluids
    • Tong, H.H., B.Y. Shekunov, P. York, et al. 2001. Characterization of two polymorphe of salmeterol xinafoate crystallized from supercritcal fluids. Pharm. Res. 18:852-858.
    • (2001) Pharm. Res. , vol.18 , pp. 852-858
    • Tong, H.H.1    Shekunov, B.Y.2    York, P.3
  • 14
    • 8644225861 scopus 로고    scopus 로고
    • Powder characterization tests: Can they make a difference in product development
    • Davis Horwood International, Tucson
    • Feeley, J. 2002. Powder characterization tests: Can they make a difference in product development. In Respiratory Drug Delivery VIII. Davis Horwood International, Tucson.
    • (2002) Respiratory Drug Delivery VIII
    • Feeley, J.1
  • 15
    • 0036746761 scopus 로고    scopus 로고
    • Predicting the quality of powders for inhalation from surface energy and area
    • Cline, D. and R. Dalby. 2002. Predicting the quality of powders for inhalation from surface energy and area. Pharm. Res. 19:1274-1277.
    • (2002) Pharm. Res. , vol.19 , pp. 1274-1277
    • Cline, D.1    Dalby, R.2
  • 16
    • 27944481620 scopus 로고    scopus 로고
    • Effect of amino acids on the dispersion of disodium cromoglycate powders
    • Chew, N.Y.K., B.Y. Shekunov, H.H.Y. Tong, et al. 2005. Effect of amino acids on the dispersion of disodium cromoglycate powders. J. Pharm. Sci. 94:2289-2300.
    • (2005) J. Pharm. Sci. , vol.94 , pp. 2289-2300
    • Chew, N.Y.K.1    Shekunov, B.Y.2    Tong, H.H.Y.3
  • 17
    • 3042762797 scopus 로고    scopus 로고
    • An atomic force microscopy study of the effect of nanoscale contact geometry and surface chemistry on the adhesion of pharmaceutical particles
    • Hooton, J.C. 2004. An atomic force microscopy study of the effect of nanoscale contact geometry and surface chemistry on the adhesion of pharmaceutical particles. Pharm. Res. 21:953-961.
    • (2004) Pharm. Res. , vol.21 , pp. 953-961
    • Hooton, J.C.1
  • 18
    • 0030982757 scopus 로고    scopus 로고
    • Aerosol electrostatics. I. Properties of fine powders before and after aerosolization by dry powder inhalers
    • Byron, P., R. Pearl, S. Joanne, et al. 1997. Aerosol electrostatics. I. Properties of fine powders before and after aerosolization by dry powder inhalers. Pharm. Res. 14:698-705.
    • (1997) Pharm. Res. , vol.14 , pp. 698-705
    • Byron, P.1    Pearl, R.2    Joanne, S.3
  • 19
    • 2442636913 scopus 로고    scopus 로고
    • Electrostatic charge characterization of pharmaceutical aerosols using electrical low-pressure impactor (ELPI)
    • Glover, W., and H.-K. Chan. 2004. Electrostatic charge characterization of pharmaceutical aerosols using electrical low-pressure impactor (ELPI). J. Aerosol Sci. 35:755-764.
    • (2004) J. Aerosol Sci. , vol.35 , pp. 755-764
    • Glover, W.1    Chan, H.-K.2
  • 20
    • 33745012500 scopus 로고    scopus 로고
    • Electrostatic charge characterization of pharmaceutical aerosols
    • Davis Healthcare, Palm Desert, CA
    • Glover, W., and H.-K. Chan. 2004. Electrostatic charge characterization of pharmaceutical aerosols. In Respiratory Drug Delivery IX. Davis Healthcare, Palm Desert, CA.
    • (2004) Respiratory Drug Delivery IX
    • Glover, W.1    Chan, H.-K.2
  • 21
    • 11344262013 scopus 로고    scopus 로고
    • Direct-reading techniques using particles motion and optical detection
    • P.A. Baron and K. Willeke, eds. Wiley-Interscience, New York
    • Baron, P.A., M.K. Mazumder, and Y.-S. Cheng. 2001. Direct-reading techniques using particles motion and optical detection. In P.A. Baron and K. Willeke, eds. Aerosol Measurement Principles, Techniques, and Applications. Wiley-Interscience, New York, 495-527.
    • (2001) Aerosol Measurement Principles, Techniques, and Applications , pp. 495-527
    • Baron, P.A.1    Mazumder, M.K.2    Cheng, Y.-S.3
  • 22
    • 0346398314 scopus 로고    scopus 로고
    • Bipolar electrostatic charging of fine pharmaceutical powders by dispersion and transport processes and its implications to lung deposition of inhaled DPI aerosols
    • Davis Horwood International, Raleigh, NC
    • Mazumder, M.K., C.U. Yurteri, G. Ahuja, et al. 2002. Bipolar electrostatic charging of fine pharmaceutical powders by dispersion and transport processes and its implications to lung deposition of inhaled DPI aerosols. In Respiratory Drug Delivery VIII. Davis Horwood International, Raleigh, NC.
    • (2002) Respiratory Drug Delivery VIII
    • Mazumder, M.K.1    Yurteri, C.U.2    Ahuja, G.3
  • 23
    • 0031245753 scopus 로고    scopus 로고
    • The inhalation and deposition of charged particles within the human lung
    • Bailey, A.G. 1997. The inhalation and deposition of charged particles within the human lung. J. Electrostatics 42:25-32.
    • (1997) J. Electrostatics , vol.42 , pp. 25-32
    • Bailey, A.G.1
  • 24
    • 0031168694 scopus 로고    scopus 로고
    • Control of drug aerosol in human airways using electrostatic forces
    • Balachandran, W., M.W. Gaura, and C. Hudson. 1997. Control of drug aerosol in human airways using electrostatic forces. J. Electrostatics 40:579-584.
    • (1997) J. Electrostatics , vol.40 , pp. 579-584
    • Balachandran, W.1    Gaura, M.W.2    Hudson, C.3
  • 25
    • 0020970661 scopus 로고
    • Deposition of charged particles in the human airways
    • Melandri, C., T.G. Prodi, V. De Zaiacomo, et al. 1983. Deposition of charged particles in the human airways. J. Aerosol Sci. 14:657-669.
    • (1983) J. Aerosol Sci. , vol.14 , pp. 657-669
    • Melandri, C.1    Prodi, T.G.2    De Zaiacomo, V.3
  • 26
    • 0031008878 scopus 로고    scopus 로고
    • Spray dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery
    • Chan, H.-K., A. Clark, I. Gonda, et al. 1997. Spray dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery. Pharm. Res. 14:431-437.
    • (1997) Pharm. Res. , vol.14 , pp. 431-437
    • Chan, H.-K.1    Clark, A.2    Gonda, I.3
  • 27
    • 0031925636 scopus 로고    scopus 로고
    • Protein deposition from dry powder inhalers: Fine particle multiplets as performance modifiers
    • Lucas, P., K. Anderson, and J.N. Staniforth. 1998. Protein deposition from dry powder inhalers: fine particle multiplets as performance modifiers. Pharm. Res. 15:562-569.
    • (1998) Pharm. Res. , vol.15 , pp. 562-569
    • Lucas, P.1    Anderson, K.2    Staniforth, J.N.3
  • 28
    • 20044363723 scopus 로고    scopus 로고
    • The cohesive-adhesive balances in dry powder inhaler formulations. I. Direct quantification by atomic force microscopy
    • Begat, P., D.A.V. Morton, J.N. Staniforth, et al. 2004. The cohesive-adhesive balances in dry powder inhaler formulations. I. Direct quantification by atomic force microscopy. Pharm. Res. 21:1591-1597.
    • (2004) Pharm. Res. , vol.21 , pp. 1591-1597
    • Begat, P.1    Morton, D.A.V.2    Staniforth, J.N.3
  • 29
    • 0033066810 scopus 로고    scopus 로고
    • Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation
    • Zeng, X.M., G.P. Martin, S.-K. Tee, et al. 1999. Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation. Int. J. Pharm. 182:133-144.
    • (1999) Int. J. Pharm. , vol.182 , pp. 133-144
    • Zeng, X.M.1    Martin, G.P.2    Tee, S.-K.3
  • 30
    • 0036804484 scopus 로고    scopus 로고
    • Particle interactions involved in aerosol dispersion of ternary interactive mixtures
    • Louey, M.D., and P.J. Stewart. 2002. Particle interactions involved in aerosol dispersion of ternary interactive mixtures. Pharm. Res. 19:1524-1531.
    • (2002) Pharm. Res. , vol.19 , pp. 1524-1531
    • Louey, M.D.1    Stewart, P.J.2
  • 31
    • 6344245649 scopus 로고    scopus 로고
    • The cohesive-adhesive balances in dry powder inhaler formulations. II. Influence on fine particle delivery characteristics
    • Begat, P., D.A.V. Morton, J.N. Staniforth, et al. 2004. The cohesive-adhesive balances in dry powder inhaler formulations. II. Influence on fine particle delivery characteristics. Pharm. Res. 21:1826-1833.
    • (2004) Pharm. Res. , vol.21 , pp. 1826-1833
    • Begat, P.1    Morton, D.A.V.2    Staniforth, J.N.3
  • 32
    • 85057937388 scopus 로고    scopus 로고
    • Dry-powder inhalers
    • H. Bisgaard, C. O'-Callaghan, and G.C. Smaldone, eds. Marcel Dekker, New York
    • Borgstrom, L., H. Bisgaard, C. O'Callaghan, et al. 2002. Dry-powder inhalers. In H. Bisgaard, C. O'-Callaghan, and G.C. Smaldone, eds. Drug Delivery to the Lung. Marcel Dekker, New York, 421-448.
    • (2002) Drug Delivery to the Lung , pp. 421-448
    • Borgstrom, L.1    Bisgaard, H.2    O'Callaghan, C.3
  • 33
    • 0037032434 scopus 로고    scopus 로고
    • Deagglomeration of dry powder pharmaceutical aerosols
    • Voss, A.P., and W.H. Finlay. 2002. Deagglomeration of dry powder pharmaceutical aerosols. Int. J. Pharm. 248:39-50.
    • (2002) Int. J. Pharm. , vol.248 , pp. 39-50
    • Voss, A.P.1    Finlay, W.H.2
  • 35
    • 8644282632 scopus 로고    scopus 로고
    • Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1. Grid structure and mouthpiece length
    • Coates, M., D. Fletcher, H.-K. Chan, et al. 2004. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1. Grid structure and mouthpiece length. J. Pharm. Sci. 93:2863-2876.
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2863-2876
    • Coates, M.1    Fletcher, D.2    Chan, H.-K.3
  • 36
    • 0034270029 scopus 로고    scopus 로고
    • Computer simulation of the packing of fine particles
    • Yang, R.Y., R.P. Zou, and A.B. Yu. 2000. Computer simulation of the packing of fine particles. Phys. Rev. E 62:3900-3907.
    • (2000) Phys. Rev. E , vol.62 , pp. 3900-3907
    • Yang, R.Y.1    Zou, R.P.2    Yu, A.B.3
  • 37
    • 0037453810 scopus 로고    scopus 로고
    • Effect of the impact angle on the breakage of agglomerates: A numerical study using DEM
    • Moreno, R., M. Ghadiri, and S.J. Antony. 2003. Effect of the impact angle on the breakage of agglomerates: a numerical study using DEM. Powder Technol. 130:132-137.
    • (2003) Powder Technol. , vol.130 , pp. 132-137
    • Moreno, R.1    Ghadiri, M.2    Antony, S.J.3
  • 38
    • 0037453836 scopus 로고    scopus 로고
    • Effect of structural characteristics on impact breakage of agglomerates
    • Samimi, A., M. Ghadiri, R. Boerefijn, et al. 2003. Effect of structural characteristics on impact breakage of agglomerates. Powder Technol. 130:428-435.
    • (2003) Powder Technol. , vol.130 , pp. 428-435
    • Samimi, A.1    Ghadiri, M.2    Boerefijn, R.3
  • 39
    • 85034250334 scopus 로고    scopus 로고
    • In vitro testing of pharmaceutical aerosols and predicting lung deposition from in vitro measurements
    • H. Bisgaard, C. O'Callaghan, and G.C. Smaldone, eds. Marcel Dekker, New York
    • Clark, A., and L. Borgstrom. 2002. In vitro testing of pharmaceutical aerosols and predicting lung deposition from in vitro measurements. In H. Bisgaard, C. O'Callaghan, and G.C. Smaldone, eds. Drug Delivery to the Lung. Marcel Dekker, New York, 105-142.
    • (2002) Drug Delivery to the Lung , pp. 105-142
    • Clark, A.1    Borgstrom, L.2
  • 40
    • 0034862979 scopus 로고    scopus 로고
    • Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways
    • Lin, T.-C., P.N. Breysse, L.L. Beth, et al. 2001. Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways. J. Aerosol Med. 14:335-341.
    • (2001) J. Aerosol Med. , vol.14 , pp. 335-341
    • Lin, T.-C.1    Breysse, P.N.2    Beth, L.L.3
  • 41
    • 3342902533 scopus 로고    scopus 로고
    • Fluid mechanics and particle deposition in the oropharynx: The factors that really matter
    • Davis Horwood International, Tucson
    • Finlay, W.H., W. De Haan, B. Grgic, et al. 2002. Fluid mechanics and particle deposition in the oropharynx: the factors that really matter. In Respiratory Drug Delivery VIII. Davis Horwood International, Tucson.
    • (2002) Respiratory Drug Delivery VIII
    • Finlay, W.H.1    De Haan, W.2    Grgic, B.3
  • 42
    • 3242684091 scopus 로고    scopus 로고
    • Particle deposition measurements and numerical simulation in a highly idealized mouth-throat
    • Zhang, Y., W.H. Finlay, and E.A. Matida. 2004. Particle deposition measurements and numerical simulation in a highly idealized mouth-throat. J. Aerosol Sci. 35:789-803.
    • (2004) J. Aerosol Sci. , vol.35 , pp. 789-803
    • Zhang, Y.1    Finlay, W.H.2    Matida, E.A.3
  • 43
    • 0033286451 scopus 로고    scopus 로고
    • Particle deposition in a cast of human oral airways
    • Cheng, Y.-S., Y. Zhou, and B.T. Chen. 1999. Particle deposition in a cast of human oral airways. Aerosol Sci. Technol. 31:286-300.
    • (1999) Aerosol Sci. Technol. , vol.31 , pp. 286-300
    • Cheng, Y.-S.1    Zhou, Y.2    Chen, B.T.3
  • 44
    • 0037263890 scopus 로고    scopus 로고
    • Particle characteristics and lung deposition patterns in a human airway replica of a dry powder formulation of polyactic acid produced using supercritical fluid technology
    • Cheng, Y.S., D. Yazzie, B.S. Gao, et al. 2003. Particle characteristics and lung deposition patterns in a human airway replica of a dry powder formulation of polyactic acid produced using supercritical fluid technology. J. Aerosol Med. 16:65-73.
    • (2003) J. Aerosol Med. , vol.16 , pp. 65-73
    • Cheng, Y.S.1    Yazzie, D.2    Gao, B.S.3
  • 45
    • 1642515060 scopus 로고    scopus 로고
    • Studies of the human oropharyngeal airspaces using magnetic resonance imaging. I. Validation of a three-dimensional MRI method for producing ex vivo virtual and physical casts of the oropharyngeal airways during inspiration
    • McRobbie, D.W., S. Pritchard, and R.A. Quest. 2003. Studies of the human oropharyngeal airspaces using magnetic resonance imaging. I. Validation of a three-dimensional MRI method for producing ex vivo virtual and physical casts of the oropharyngeal airways during inspiration. J. Aerosol Med. 16:401-415.
    • (2003) J. Aerosol Med. , vol.16 , pp. 401-415
    • McRobbie, D.W.1    Pritchard, S.2    Quest, R.A.3
  • 46
    • 3342886225 scopus 로고    scopus 로고
    • An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways
    • Heenan, A.F., W.H. Finlay, B. Grgic, et al. 2004. An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways. J. Aerosol Sci. 35:1013-1023.
    • (2004) J. Aerosol Sci. , vol.35 , pp. 1013-1023
    • Heenan, A.F.1    Finlay, W.H.2    Grgic, B.3
  • 47
    • 3242722612 scopus 로고    scopus 로고
    • In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries
    • Grgic, B., W.H. Finlay, P.K.P. Burnell, et al. 2004. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J. Aerosol Sci. 35:1025-1040.
    • (2004) J. Aerosol Sci. , vol.35 , pp. 1025-1040
    • Grgic, B.1    Finlay, W.H.2    Burnell, P.K.P.3
  • 48
    • 4644308094 scopus 로고    scopus 로고
    • Validation of the conceptual anatomical model of the lung airway
    • Fleming, J.S., V. Sauret, J.H. Conway, et al. 2004. Validation of the conceptual anatomical model of the lung airway. J. Aerosol Med. 17:260-269.
    • (2004) J. Aerosol Med. , vol.17 , pp. 260-269
    • Fleming, J.S.1    Sauret, V.2    Conway, J.H.3


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