Synthesis and in vitro evaluation of 3H-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity

ChemMedChem

Volumn 5, Issue 8, 2010, Pages 1373-1385

  Ferlin, Maria Grazia ^a   Bortolozzi, Roberta ^a   Brun, Paola ^a   Castagliuolo, Ignazio ^a   Hamel, Ernest ^b   Basso, Giuseppe ^a   Viola, Giampietro ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anticancer agents; Antiproliferative activity; Apoptosis; Pyrroloquinolinones; Tubulin

Indexed keywords

3 ETHYL 7 (PYRIDIN 3 YL) 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; 3 ETHYL 8 (3 METHOXYPHENYL) 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; 3 ETHYL 8 PHENYL 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; 3 ETHYL 9 OXO 7 PHENYL 6,9 DIHYDRO 3H PYRROLO [3,2 F] QUINOLINE 1 CARBONITRILE; 3 ETHYL 9 OXO 7 PHENYL 6,9 DIHYDRO 3H PYRROLO [3,2 F] QUINOLINE 1 CARBOXAMIDE; 3 METHYLCYCLOPROPYL 8 PHENYL 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; 7 PHENYL 3 (3,4,5 TRIMETHOXYBENZYL) 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; 7 PHENYL 3H PYRROLO [3,2 F] QUINOLIN 9 ONE DERIVATIVE; 8 (4 BROMOPHENYL) 3 ETHYL 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; 8 PHENYL 3H PYRROLO [3,2 F] QUINOLIN 9(6H) ONE; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; CASPASE 3; COLCHICINE; COMBRESTASTATIN A 4; ETHYL 3 [9 OXO 7 PHENYL 6H PYRROLO [3,2 F] QUINOLIN 3(9H) YL] PROPANOATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MICROTUBULE ASSEMBLY; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; LEUKEMIA; PYRROLES; QUINOLINES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 77955101686     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000180     Document Type: Article

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