Hexyl aminolaevulinate is a more effective topical photosensitiser precursor than methyl aminolaevulinate and 5-aminolaevulinic acids when applied in equimolar doses

Journal of Pharmaceutical Sciences

Volumn 99, Issue 8, 2010, Pages 3486-3498

  Morrow, Desmond I J ^a,b   McCarron, Paul A ^c   Woolfson, A David ^a   Juzenas, Petras ^d   Juzeniene, Asta ^b   Iani, Vladimir ^b   Moan, Johan ^b   Donnelly, Ryan F ^a,b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF ULSTER   (United Kingdom)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

5 Aminolaevulinic acid; Drug delivery; Esters; Percutaneous; Prodrugs; Skin; Topical

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID HEXYL ESTER; AMINOLEVULINIC ACID METHYL ESTER; PHOTOSENSITIZING AGENT; PROTOPORPHYRIN; WATER OIL CREAM; 5-AMINOLEVULINIC ACID HEXYL ESTER; METHYL 5-AMINOLEVULINATE; OINTMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DISTRIBUTION; FEMALE; FLUORESCENCE; HYDROPHOBICITY; LIPOPHILICITY; MOUSE; NONHUMAN; SKIN PENETRATION; SWINE; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; IN VITRO STUDY; ISOTOPE LABELING; MEDICINAL CHEMISTRY; NEWBORN; OINTMENT; SKIN; SKIN ABSORPTION; SYNTHESIS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AMINOLEVULINIC ACID; ANIMALS; ANIMALS, NEWBORN; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; IN VITRO TECHNIQUES; ISOTOPE LABELING; MICE; MICE, INBRED BALB C; OINTMENTS; PHOTOSENSITIZING AGENTS; SKIN; SKIN ABSORPTION; SWINE;

EID: 77955098944     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22116     Document Type: Article

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