Combined Superoxide Dismutase/Catalase Mimetics Alter Fetal Pulmonary Arterial Smooth Muscle Cell Growth

Antioxidants and Redox Signaling

Volumn 6, Issue 1, 2004, Pages 191-197

  Wedgwood, Stephen ^a   Black, Stephen M ^a,b,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MONTANA   (United States)

^c St Patrick Hospital and Health Sciences Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; HYDROETHIDINE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); PROTEIN P21; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTERY MUSCLE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; DOSE RESPONSE; ENZYME INHIBITION; FLOW CYTOMETRY; LUNG ARTERY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; TITRIMETRY;

ANIMALIA;

EID: 0346690282     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/152308604771978507     Document Type: Article

References (28)

1. Anderson I, Adinolfi C, Doctrow SR, Huffman K, Joy KA, Malfroy B, Soden P, Rupniak HT, and Barnes JC. Oxidative signalling and inflammatory pathways in Alzheimer's disease. Biochem Soc Symp 141-149, 2001.
2. Baker K, Marcus CB, Huffman K, Kruk H, Malfroy B, and Doctrow SR. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284: 215-221, 1998.
3. Baudry M, Etienne S, Bruce A, Palucki M, Jacobsen E, and Malfroy B. Salen-manganese complexes are superoxide dismutase-mimics. Biochem Biophys Res Commun 192: 964-968, 1993.
4. Brennan LA, Steinhorn RH, Wedgwood S, Mata-Greenwood E, Roark EA, Russell JA, and Black SM. Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res 92: 683-691, 2003.
5. Brown MR, Miller FJ, Li WG, Ellingson AN, Mozena JD, Chatterjee PK, Engelhardt JF, Zwacka RM, Oberley LW, Fang X, Spector AA, and Weintraub NL. Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. Circ Res 85: 524-533, 1999.
6. Cory AH, Owen TC, Barltrop JA, and Cory JG. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 3: 207-212, 1991.
7. Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, and Weinberg RA. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73: 499-511, 1993.
8. Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, and Fink MP. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther 275: 798-806, 1995.
9. Griendling KK, Minieri CA, Ollerenshaw JD, and Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994.
10. Grunfeld S, Hamilton CA, Mesaros S, McClain SW, Dominiczak AF, Bohr DF, and Malinski T. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. Hypertension 26: 854-857, 1995.
11. Harper JW, Adami GR, Wei N, Keyomarsi K, and Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816, 1993.
12. Jung C, Rong Y, Doctrow SR, Baudry M, Malfroy B, and Xu Z. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci Lett 304: 157-160, 2001.
13. Langenstroer P and Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol 263: H257-H265, 1992.
14. Ohara Y, Peterson TE, and Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91: 2546-2551, 1993.
15. Pagano M, Pepperkok R, Verde F, Ansorge W, and Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J 11: 961-971, 1992.
16. Rao GN and Berk BC. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res 18: 775-794, 1992.
17. Rong Y, Doctrow SR, Tocco G, and Baudry M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci USA 96: 9897-9902, 1999.
18. Ross R. A pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809, 1993.
19. Roy S, Khanna S, Bickerstaff AA, Subramanian SV, Atalay M, Bierl M, Pendyala S, Levy D, Sharma N, Venojarvi M, Strauch A, Orosz CG, and Sen CK. Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Wafl/Cipl/ Sdi1). Circ Res 92: 264-271, 2003.
20. Sharpe MA, Ollosson R, Stewart VC, and Clark JB. Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Biochem J 366: 97-107, 2002.
21. Sherr CJ. Cancer cell cycles. Science 274: 1672-1677, 1996.
22. Sherr CJ and Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
23. 2 for platelet-derived growth factor signal transduction. Science 270: 296-299, 1995.
24. Tsai JC, Jain M, Hsieh CM, Lee WS, Yoshizumi M, Patterson C, Perralla MA, Cook C, Wang H, Haber E, Schlegal R, and Lee ME. Induction of apoptosis by pyrrolidinedithio-carbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem 271: 3667-3670, 1996.
25. Wedgwood S and Black SM. Induction of apoptosis in fetal pulmonary arterial smooth muscle cells by a combined superoxide dismutase/catalase mimetic. Am J Physiol Lung Cell Mol Physiol 285: L305-L312, 2003.
26. Wedgwood S, Dettman RW, and Black SM. ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 281: L1058-L1067, 2001.
27. Wedgwood S, Brennan LA, Lu J, Jilling T, and Black SM. Biphasic effects of nitric oxide on fetal pulmonary arterial smooth muscle cell growth. Pediatr Res 51: 390A, 2002.
28. Wedgwood S, Mitchell CJ, Fineman JR, and Black SM. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol 284: L650-L662, 2003.