Ferritin does not donate its iron for haem synthesis in macrophages

Biochemical Journal

Volumn 429, Issue 3, 2010, Pages 463-471

  Mikhael, Marc ^a,b   Sheftel, Alex D ^c   Ponka, Prem ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Aminolevulinic acid; Ferritin; Haem synthesis; Iron metabolism

Indexed keywords

5-AMINOLAEVULINIC ACID; AMINOLEVULINIC ACID; ERYTHROID CELLS; FERRITIN; HAEM SYNTHESIS; IRON METABOLISM; METABOLIC FUNCTION; MURINE MACROPHAGES; SINGLE CELLS;

ACIDS; CELL CULTURE; MACROPHAGES;

METABOLISM;

AMINOLEVULINIC ACID; FERRITIN; IRON; IRON 59; TRANSFERRIN; HEME; HEME OXYGENASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL METABOLISM; CONTROLLED STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS; RETICULOCYTE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; ENZYMOLOGY; FEMALE; HOMEOSTASIS; IMMUNOPRECIPITATION; METABOLISM;

MURINAE;

AMINOLEVULINIC ACID; ANIMALS; BLOTTING, WESTERN; CELL LINE; FEMALE; FERRITINS; HEME; HEME OXYGENASE (DECYCLIZING); HOMEOSTASIS; IMMUNOPRECIPITATION; IRON; MACROPHAGES; MICE;

EID: 77955082503     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100346     Document Type: Article

References (51)

1. De Domenico, I., McVey Ward, D. and Kaplan, J. (2008) Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat. Rev. Mol. Cell Biol. 9, 72-81
2. Richardson, D. R. and Ponka, P. (1997) The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim. Biophys. Acta 1331, 1-40
3. Eaton, J. W. and Qian, M. (2002) Molecular bases of cellular iron toxicity. Free Radical Biol. Med. 32, 833-840
4. Arosio, P. and Levi, S. (2002) Ferritin, iron homeostasis, and oxidative damage. Free Radical Biol. Med. 33, 457-463
5. Harrison, P. M. and Arosio, P. (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochim. Biophys. Acta 1275, 161-203
6. Zail, S. S., Charlton, R. W., Torrance, J. D. and Bothwell, T. H. (1964) Studies on the formation of ferritin in red cell precursors. J. Clin. Invest. 43, 670-680
7. Bothwell, T. J., Charlton, R. W., Cook, J. D. and Finch, C. A. (1979) Iron Metabolism in Man, Blackwell Scientific, Oxford
8. Mazur, A. and Carleton, A. (1963) Relation of ferritin iron to heme synthesis in marrow and reticulocytes. J. Biol. Chem. 238, 1817-1824
9. Nunez, M. T., Glass, J. and Robinson, S. H. (1978) Mobilization of iron from the plasma membrane of the murine reticulocyte. The role of ferritin. Biochim. Biophys. Acta 509, 170-180
10. Peto, T. E., Rutherford, T. R., Thompson, J. L. and Weatherall, D. J. (1983) Iron metabolism in murine erythroleukaemic cells. Br. J. Haematol. 54, 623-631
11. Vaisman, B., Fibach, E. and Konijn, A. M. (1997) Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors. Blood 90, 831-838
12. Borova, J., Ponka, P. and Neuwirt, J. (1973) Study of intracellular iron distribution in rabbit reticulocytes with normal and inhibited heme synthesis. Biochim. Biophys. Acta 320, 143-156
13. Ponka, P. and Richardson, D. R. (1997) Can ferritin provide iron for hemoglobin synthesis? Blood 89, 2611-2613
14. Adams, M. L., Ostapiuk, I. and Grasso, J. A. (1989) The effects of inhibition of heme synthesis on the intracellular localization of iron in rat reticulocytes. Biochim. Biophys. Acta 1012, 243-253
15. Grasso, J. A., Hillis, T. J. and Mooney-Frank, J. A. (1984) Ferritin is not a required intermediate for iron utilization in heme synthesis. Biochim. Biophys. Acta 797, 247-255
16. Ponka, P., Wilczynska, A. and Schulman, H. M. (1982) Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitor or heme synthesis. Biochim. Biophys. Acta 720, 96-105
17. Primosigh, J. V. and Thomas, E. D. (1968) Studies on the partition of iron in bone marrow cells. J. Clin. Invest. 47, 1473-1482
18. Richardson, D. R., Ponka, P. and Vyoral, D. (1996) Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism. Blood 87, 3477-3488 (Pubitemid 26115381)
19. Hemmaplardh, D. and Morgan, E. H. (1974) The mechanism of iron exchange between synthetic iron chelators and rabbit reticulocytes. Biochim. Biophys. Acta 373, 84-99
20. Zhang, A. S., Sheftel, A. D. and Ponka, P. (2005) Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria. Blood 105, 368-375
21. Sheftel, A. D., Zhang, A. S., Brown, C., Shirihai, O. S. and Ponka, P. (2007) Direct interorganellar transfer of iron from endosome to mitochondrion. Blood 110, 125-132 (Pubitemid 47026827)
22. Picard, V., Renaudie, F., Porcher, C., Hentze, M. W., Grandchamp, B. and Beaumont, C. (1996) Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution. Blood 87, 2057-2064
23. Darshan, D., Vanoaica, L., Richman, L., Beermann, F. and Kühn, L.C. (2009) Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Hepatology 50, 852-860
24. Knutson, M. and Wessling-Resnick, M. (2003) Iron metabolism in the reticuloendothelial system. Crit. Rev. Biochem. Mol. Biol. 38, 61-88
25. Ganz, T. (2006) Hepcidin: a peptide hormone at the interface of innate immunity and iron metabolism. Curr. Top. Microbiol. Immunol. 306, 183-198
26. Abboud, S. and Haile, D. J. (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275, 19906-19912
27. McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F. et al. (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5, 299-309
28. Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T. and Kaplan, J. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090-2093 (Pubitemid 40007660)
29. Kim, S. and Ponka, P. (2002) Nitrogen monoxide-mediated control of ferritin synthesis: implications for macrophage iron homeostasis. Proc. Natl. Acad. Sci. U.S.A. 99, 12214-12219
30. Mikhael, M., Kim, S. F., Schranzhofer, M., Soe-Lin, S., Sheftel, A. D., Mullner, E. W. and Ponka, P. (2006) Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide. FEBS J. 273, 3828-3836
31. Fillet, G., Cook, J. D. and Finch, C. A. (1974) Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport. J. Clin. Invest. 53, 1527-1533
32. Ponka, P. (1999) Cell biology of heme. Am. J. Med. Sci. 318, 241-256
33. Vander, A., Sherman, J. and Luciano, D. (1994) Human Physiology, McGraw-Hill Publishing Company, New York
34. De Domenico, I., Vaughn, M. B., Li, L., Bagley, D., Musci, G., Ward, D. M. and Kaplan, J. (2006) Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J. 25, 5396-5404 (Pubitemid 44764148)
35. Martinez-Medellin, J. and Schulman, H. M. (1972) The kinetics of iron and transferrin incorporation into rabbit erythroid cells and the nature of stromal-bound iron. Biochim. Biophys. Acta 264, 272-274
36. Ponka, P. and Schulman, H. M. (1985) Acquisition of iron from transferrin regulates reticulocyte heme synthesis. J. Biol. Chem. 260, 14717-14721
37. Ponka, P., Borova, J., Neuwirt, J., Fuchs, O. and Necas, E. (1979) A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents. Biochim. Biophys. Acta 586, 278-297
38. Mullner, E. W., Neupert, B. and Kuhn, L. C. (1989) A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell 58, 373-382
39. Soe-Lin, S., Sheftel, A. D., Wasyluk, B. and Ponka, P. (2008) Nramp1 equips macrophages for efficient iron recycling. Exp. Hematol. 36, 929-937
40. Williams, W. J., Beutler, E., Erslev, A. J. and Lictman, M. A. (1990) Hematology, McGraw-Hill Publishing Company, New York
41. Ponka, P., Neuwirt, J. and Borova, J. (1973) The use of exogenous δ-aminolevulinic acid for the studies of the regulation of haem synthesis in rabbit reticulocytes. Biochim. Biophys. Acta 304, 123-131
42. Maines, M. D. (2005) The heme oxygenase system: update 2005. Antioxid. Redox Signaling 7, 1761-1766
43. Leibold, E. A. and Munro, H. N. (1988) Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc. Natl. Acad. Sci. U.S.A. 85, 2171-2175
44. Walden, W. E., Patino, M. M. and Gaffield, L. (1989) Purification of a specific repressor of ferritin mRNA translation from rabbit liver. J. Biol. Chem. 264, 13765-13769
45. Goessling, L. S., Mascotti, D. P. and Thach, R. E. (1998) Involvement of heme in the degradation of iron-regulatory protein 2. J. Biol. Chem. 273, 12555-12557
46. Carvalho, H., Bechara, E. J., Meneghini, R. and Demasi, M. (1997) Haem precursor delta-aminolaevulinic acid induces activation of the cytosolic iron regulatory protein 1. Biochem. J. 328, 827-832
47. Hoffman, R., Benz E.R., Shattil S. J., Furie B., Cohen H. J. and Silberstein L.E., McGlave P. (2000) Hematology: Basic Principles and Practice, Churchill Livingstone, Philadelphia
48. Theil, E. C., Matzapetakis, M. and Liu, X. (2006) Ferritins: iron/oxygen biominerals in protein nanocages. J. Biol. Inorg. Chem. 11, 803-810
49. Sheftel, A. D., Kim, S. F. and Ponka, P. (2007) Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism. J. Biol. Chem. 282, 10480-10486
50. Sheftel, A. D. and Lill, R. (2009) The power plant of the cell is also a smithy: the emerging role of mitochondria in cellular iron homeostasis. Ann. Med. 41, 82-99
51. Goodnough, L. T. (2007) Erythropoietin and iron-restricted erythropoiesis. Exp. Hematol. 35, 167-172