Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat

Journal of Neurotrauma

Volumn 27, Issue 7, 2010, Pages 1275-1282

  Kuypers, Nicholas J ^a   Hoane, Michael R ^a  

^a SOUTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

B vitamin; controlled cortical impact; recovery of function; traumatic brain injury; treatment; vitamin B6; vitanutrient

Indexed keywords

P4722; PYRIDOXINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CONTUSION; CONTROLLED STUDY; CONVALESCENCE; DRUG DOSE COMPARISON; DRUG EFFICACY; FORELIMB; LATENT PERIOD; MALE; NEUROANATOMY; NONHUMAN; RAT; SENSORIMOTOR CORTEX; SOMATOSENSORY SYSTEM; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME; VIBRISSA;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PYRIDOXINE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; VITAMIN B 6;

EID: 77955075524     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2010.1327     Document Type: Article

References (50)

1. Adekoya, N., Thurman, D., White, D., and Webb, K. (2002). Surveillance for traumatic brain injury deaths\United States. Morb. Mortal. Weekly Rep. 51, 1-14.
2. Barbre, A.B., and Hoane, M.R. (2006). Magnesium and riboflavin combination therapy following cortical contusion injury in the rat. Brain Res. Bull. 69, 639-646.
3. Barth, T.M., Grant, M.L., and Schallert, T. (1990). Effects of MK-801 on recovery from sensorimotor cortex lesions. Stroke 21, III-153-III-157.
4. Becerra, G.D., Tatko, L.M., Pak, E.S., Murashov, A.K., and Hoane, M.R. (2007). Transplantation of GABAergic neurons but not astrocytes induces recovery of sensorimotor function in the traumatically injured brain. Behav. Brain Res. 179, 118-125.
5. 6. Br. J. Nutr. 81, 7-20.
6. Betz, A.L., Ren, X.D., Ennis, S.R., and Hultquist, D.E. (1994). Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir. (Wien.) 60, 314-317.
7. 6 deficiency affects anti-oxidant defences in rat liver and heart. Biochem. Mol. Biol. Int. 46, 689-697.
8. Cernak, I., O'Connor, C., and Vink, R. (2002). Inhibition of cy-clooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats. Exp. Brain Res. 147, 193-199.
9. Chong, Z.Z., and Maiese, K. (2008). Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways. Curr. Neurovasc. Res. 5, 159-170.
10. Coggeshall, R.E. (1992). A consideration of neural counting methods. Trends Neurosci. 15, 9-13.
11. Cuskelly, G., Stacpoole, P., Williamson, J., Baumgartner, T., and Gregory, J. (2001). Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine and methionine kinetics. Am. J. Physiol. Endocrinol. Metab. 281, 182-190.
12. Friso, S., Girelli, D., Martinelli, N., Olivieri, O., Lotto, V., Bozzini, C., Pizzolo, G., Faccini, G., Beltrame, F., and Corrocher, R. (2004). Low plasma vitamin B6 concentrations and modulation of coronary artery disease risk. Am. J. Clin. Nutr. 79, 992-998.
13. Gondusky, J.S., and Reiter, M.P. (2005). Protecting military convoys in Iraq: an examination of battle injuries sustained by a mechanized battalion during Operation Iraqi Freedom II. Mil. Med. 170, 546-549.
14. 3 improves functional recovery and reduces GFAP expression following traumatic brain injury in the rat. J. Neurotrauma 20, 1189-1198.
15. 2 therapy in an electrolytic lesion model of cortical injury in the rat. Magnes. Res. 14, 51-63.
16. Hoane, M.R., Becerra, G.D., Shank, J.E., Tatko, L., Pak, E.S., Smith, M., and Murashov, A.K. (2004). Transplantation of neuronal and glial precursors dramatically improves sensori-motor function but not cognitive function in the traumatically injured brain. J. Neurotrauma 21, 163-174.
17. Hoane, M.R., Gilbert, D.R., Holland, M.A., and Pierce, J.L. (2006a). Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain. Neurosci. Lett. 408, 35-39.
18. Hoane, M.R., Kaplan, S.A., and Ellis, A.L. (2006b). The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury. Brain Res. 1125, 185-193.
19. Hoane, M.R. (2004). Magnesium therapy and recovery of function in experimental models of brain injury and neurodegen-erative disease. Clin Calcium. 14, 65-70.
20. Hoane, M.R., Pierce, J.L., Holland, M.A., and Anderson, G.D. (2008a). Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat. Neuroscience 154, 861-868.
21. Hoane, M.R., Pierce, J.L., Holland, M.A., Birky, N.D., Dang, T., Vitek, M.P., and McKenna, S.E. (2007). The novel apolipo-protein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. J. Neurotrauma 24, 1108-1118.
22. Hoane, M.R., Pierce, J.L., Kaufman, N.A., and Beare, J.E. (2008b). Variation in chronic nicotinamide treatment after traumatic brain injury can alter components of functional recovery independent of histological damage. Oxid. Med. Cell Longev. 1, 46-53.
23. Hoane, M.R., Tan, A.A., Pierce, J.L., Anderson, G.D., and Smith, D.C. (2006c). Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat. J. Neurotrauma 23, 1535-1548.
24. Hoane, M., Wolyniak, J., and Akstulewicz, S. (2005). Administration of riboflavin improves behavioral outcome and reduces edema formation and GFAP expression following traumatic brain injury. J. Neurotrauma 22, 1112-1122.
25. Holland, M.A., Tan, A.A., Smith, D.C., and Hoane, M.R. (2008). Nicotinamide treatment provides acute neuroprotection and GFAP regulation following fluid percussion injury. J. Neuro-trauma 25, 140-152.
26. 6 active form) and its neuroprotection in experimental ischemic damage. Exp. Neurol. 206, 114-125.
27. Inci, S., Ozcan, O.E., and Kilnic, K. (1998). Time-level relationship for lipid peroxidation and the protective effect of alpha-tocopherol in experimental mild and severe brain injury. Neurosurgery 43, 330-335.
28. 6 but not homo-cysteine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification. Stroke 34, 51-54.
29. Kozlowski, D.A., Nahed, B.V., Hovda, D.A., and Lee, S.M. (2004). Paradoxical effects of cortical impact injury on en-rivonmentally enriched rats. J. Neurotrauma 21, 513-519.
30. 6 in rat primary sensory neurons. J. Neuropathol. Exp. Neurol. 44, 117-129.
31. Krinke, G., Schaumburg, H., and Spencer, P. (1980). Pyridoxine mega-vitaminosis produces degeneration of peripheral sensory neurons (sensory neuropathy) in the dog. Neurotoxicol-ogy 2, 13-24.
32. Kruman, I., Bruce-Keller, A.J., Bredesen, D.E., Waeg, G., and Mattson, M.P. (1997). Evidence that 4-hydroxynonenal mediates oxidative stress induced neuronal apoptosis. J. Neurosci. 17, 5089-5100.
33. Lipton, S.A., Kim, W.K., Choi, Y.B., Kumar, S., D'emilia, D.M., Rayudu, P.V., Arnell, D.R., and Stamler, J.S. (1997). Neur-toxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. U.S.A. 94, 5923-5928.
34. Maiese, K., Chong, Z.Z., Hou, J., and Shang, Y.C. (2009). The vitamin nicotinamide: translating nutrition into clinical care. Molecules 14, 3446-3485.
35. Narayan, R.K., Michel, M.E., Ansell, B., Baethmann, A., Biegon, A., Bracken, M.B., Bullock, M.R., Choi, S.C., Clifton, G.L., Contant, C.F., Coplin, W.M., Dietrich, W.D., Ghajar, J., Grady, S.M., Grossman, R.G., Hall, E.D., Heetderks, W., Hovda, D.A., Jallo, J., Katz, R.L., Knoller, N., Kochanek, P.M., Maas, A.I., Majde, J., Marion, D.W., Marmarou, A., Marshall, L.F., McIntosh, T.K., Miller, E., Mohberg, N., Muizelaar, J.P., Pitts, L.H., Quinn, P., Riesenfeld, G., Robertson, C.S., Strauss, K.I., Teasdale, G., Temkin, N., Tuma, R., Wade, C., Walker, M.D., Weinrich, M., Whyte, J., Wilberger, J., Young, A.B., and Yurkewicz, L. (2002). Clinical trials in head injury. J. Neuro-trauma 19, 503-557.
36. 6 deficiency on glycogen metabolism in the skeletal muscle, heart, and liver of rats. J. Nutr. Sci. Vitaminol. 37, 349-357.
37. 6. Nutr. Res. Rev. 14, 257-266.
38. Parry, G., and Bredesen, D.E. (1985). Sensory neuropathy with low-dose pyridoxine. Neurology 35, 1466-1468.
39. Paxinos, G., and Watson, C. (2005). The Rat Brain in Stereotaxic Coordinates. Elsevier: New York.
40. Perry, T.A., Weerasuriya, A., Mouton, P.R., Holloway, H.W., and Greig, N.H. (2004). Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp. Neurol. 190, 133-144.
41. Quigley, A., Tan, A.A., and Hoane, M.R. (2009). The effects of hypertonic saline and nicotinamide on sensorimotor and cognitive function following cortical contusion injury in the rat. Brain Res. 1304, 138-148.
42. 6 and neuronal function. Vitam. Horm. 22, 503-559.
43. Saatman, K.E., Duhaime, A.C., Bullock, R., Maas, A.I., Valadka, A., and Manley, G.T. (2008). Classification of traumatic brain injury for targeted therapies. J. Neurotrauma 25, 719-738.
44. Schallert, T., and Woodlee, M.T. (2005). Orienting and Placing. The Behavior of the Laboratory Rat. I.Q. Whishaw and B. Kolb (eds), Oxford University Press: New York, pps. 129-140.
45. Shen, J., Lai, C.Q., Mattei, J., Ordovas, J.M., and Tucker, K.L. (2010). Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am. J. Clin. Nutr. 91, 337-342.
46. Statler, K.D., Jenkins, L.W., Dixon, C.E., Clark, R.S., Marion, D.W., and Kochanek, P.M. (2001). The simple model versus the super model: translating experimental traumatic brain injury research to the bedside. J. Neurotrauma 18, 1195-1206.
47. Thurman, D.J., and Guerrero, J. (1999). Trends in hospitalization associated with traumatic brain injury. JAMA 282, 954-957. (Pubitemid 29420314)
48. Van Den Heuvel, C., and Vink, R. (2004). The role of magnesium in traumatic brain injury. Clin. Calcium 14, 9-14.
49. Vink, R., and Nimmo, A.J. (2009). Multifunctional drugs for head injury. Neurotherapeutics 6, 28-42.
50. Xu, Y., Sladky, J.T., and Brown, M.J. (1989). Dose-dependent expression of neuronopathy after experimental pyridoxine intoxication. Neurology 39, 1077-1083.