Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain

Neuroscience Letters

Volumn 408, Issue 1, 2006, Pages 35-39

  Hoane, Michael R ^a   Gilbert, David R ^a   Holland, Michael A ^a   Pierce, Jeremy L ^a  

^a Brain and Cognitive Science Program   (United States)

Author keywords

Edema; Fluoro jade; Neuroprotection; Nicotinamide; Rat; TBI; Vitamin B3

Indexed keywords

NICOTINAMIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; CELL DEATH; CONTROLLED STUDY; EDEMA; FROZEN SECTION; HISTOPATHOLOGY; MALE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; BRAIN INJURIES; CEREBRAL CORTEX; EDEMA; MALE; NEUROPROTECTIVE AGENTS; NIACINAMIDE; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN B COMPLEX;

EID: 33749261444     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.07.011     Document Type: Article

References (27)

1. Ayoub I.A., Lee E.J., Ogilvy C., Flint Beal M., and Maynard K.I. Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in wistar rats. Neurosci. Lett. 259 (1999) 21-24
2. Ayoub I.A., and Maynard K.I. Therapeutic window for nicotinamide following transient focal cerebral ischemia. Neuroreport 11 (2002) 213-216
3. Cernak I., Vink R., Zapple D.N., Cruz M.I., Ahmed F., Chang T., Fricke S.T., and Faden A.I. The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats. Neurobiol. Dis. 17 (2004) 29-43
4. Gupta S., Kaul C.L., and Sharma S.S. Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats. Neurol. Res. 26 (2004) 103-107
5. Hoane M., Wolyniak J., and Akstulewicz S. Administration of riboflavin improves behavioral outcome and reduces edema formation and GFAP expression following traumatic brain injury. J. Neurotrauma (2005) 1112-1122
6. 3 improves functional recovery and reduces GFAP expression following traumatic brain injury in the rat. J. Neurotrauma 20 (2003) 1189-1198
7. Hoane M.R., Becerra G.D., Shank J.E., Tatko L., Pak E.S., Smith M., and Murashov A.K. Transplantation of neuronal and glial precursors dramatically improves sensorimotor function but not cognitive function in the traumatically injured brain. J. Neurotrauma 21 (2004) 163-174
8. Hoane M.R., Tan A.A., Pierce J.L., Anderson G.D., and Smith D.C. Nicotinamide treatment reduces behavioral impairments and provides cortical protection following fluid percussion injury in the rat. J. Neurotrauma 23 (2006) 1326-1341
9. Hoffman S.W., Fulop Z., and Stein D.G. Bilateral frontal cortical contusion in rats: behavioral and anatomic consequences. J. Neurotrauma 11 (1994) 417-431
10. Janis L.S., Hoane M.R., Conde D., Fulop Z.L., and Stein D.G. Acute ethanol administration reduces the cognitive deficits associated with traumatic brain injury in rats. J. Neurotrauma 15 (1998) 105-115
11. + prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide. Neurosci. Lett. 206 (1996) 5-8
12. Li F., Chong Z.Z., and Maiese K. Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide. Curr. Med. Chem. 13 (2006) 883-895
13. Lindner M.D., Plone M.A., Cain C.K., Frydel B.R., Francis J.M., Emerich D.F., and Sutton R.L. Dissociable long-term cognitive deficits after frontal versus sensorimotor cortical contusions. J. Neurotrauma 15 (1998) 199-216
14. Maiese K., and Chong Z.Z. Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol. Sci. 24 (2003) 228-232
15. Maynard K.I., Ayoub I.A., and Shen C. Delayed multidose treatment with nicotinamide extends the degree and duration of neuroprotection by reducing infarction and improving behavioral scores up to two weeks following transient focal cerebral ischemia in wistar rats. Ann. N.Y. Acad. Sci. 939 (2001) 416-424
16. Modudai T., Ayoub I.A., Sakakibara Y., Lee E.J., Ogilvy C., and Maynard K.I. Delayed treatment with nicotinamide (vitamin B3) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in wistar rats. Stroke 31 (2000) 1679-1685
17. Mukherjee S.K., and Adams J.D. The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide. Mol. Chem. Neuropathol. 32 (1997) 59-74
18. Narayan R.K., Michel M.E., The Clinical Trials in Head Injury Study Group, Ansell B., Baethmann A., Biegon A., Bracken M.B., Ansell B., Baethmann A., Biegon A., Bracken M.B., Bullock M.R., Choi S.C., Clifton G.L., Constant C.F., Coplin W.M., Dietrich W.D., Ghajar J., Grady S.M., Grossman R.G., Hall E.D., Heetderks W., Hovda D.A., Jallo J., Katz R.L., Knoller N., Kochanek P.M., Mass A.I., Majde J., Marion D.W., Marmarou A., Marshall L.F., McIntosh T.K., Miller E., Mohberg N., Muizelaar J.P., Pitts L.H., Quinn P., Riesenfeld G., Robertson C.S., Strauss K.I., Teasdale G., Temkin N., Tuma R., Wade C., Walker M.D., Weinrich M., Whyte J., Wilberger J., Young A.B., and Yurkewicz L. Clinical trials in head injury. J. Neurotrauma 19 (2002) 503-557
19. 3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats. Brain Res. 931 (2002) 68-73
20. 3) reduces the infarct volume following permanent focal cerebral ischemia in female sprague-dawley and wistar rats. Neurosci. Lett. 281 (2000) 111-114
21. Schmued L.C., and Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874 (2000) 123-130
22. Smith D.C., Modglin A.A., Roosevelt R.W., Neese S.L., Jensen R.A., Browning R.A., and Clough R.W. Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the rat. J. Neurotrauma 22 (2005) 1485-1502
23. Statler K.D., Jenkins L.W., Dixon C.E., Clark R.S., Marion D.W., and Kochanek P.M. The simple model versus the super model: translating experimental traumatic brain injury research to the bedside. J. Neurotrauma 18 (2001) 1195-1206
24. Thurman D.J., Alverson C.A., Dunn K.A., Guerrero J., and Sniezek J.E. Traumatic brain injury in the United States: a public health perspective. J. Head Trauma Rehabil. 14 (1999) 602-615
25. Thurman D.J., and Guerrero J. Trends in hospitalization associated with traumatic brain injury. JAMA 282 (1999) 954-957
26. Ungerstedt J.S., Blomback M., and Soderstrom T. Nicotinamide is a potent inhibitor of proinflammatory cytokines. Clin. Exp. Immunol. 131 (2003) 48-52
27. Ungerstedt J.S., Heimersson K., Soderstrom T., and Hansson M. Nicotinamide inhibits endotoxin-induced monocyte tissue factor expression. J. Thromb. Haemost. 1 (2003) 2554-2560