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Volumn 643, Issue 1, 2010, Pages 139-144

Ras inhibition attenuates pancreatic cell death and experimental type 1 diabetes: Possible role of regulatory T cells

Author keywords

Diabetes; F FTS; Foxp3; NOD; Ras; Regulatory T cell

Indexed keywords

5 FLUORO FARNESYLTHIOSALICYLIC ACID; ANTIDIABETIC AGENT; CASPASE 3; INSULIN; RAS PROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 77955055583     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.029     Document Type: Article
Times cited : (12)

References (21)
  • 2
    • 33749576587 scopus 로고    scopus 로고
    • Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis
    • Blum R., Jacob-Hirsch J., Rechavi G., Kloog Y. Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. Mol. Cancer Ther. 2006, 5:2337-2347.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2337-2347
    • Blum, R.1    Jacob-Hirsch, J.2    Rechavi, G.3    Kloog, Y.4
  • 3
    • 38949093546 scopus 로고    scopus 로고
    • Inhibitors of chronically active Ras: potential for treatment of human malignancies
    • Blum R., Cox A.D., Kloog Y. Inhibitors of chronically active Ras: potential for treatment of human malignancies. Recent Pat. Anticancer Drug Discov. 2008, 3:31-47.
    • (2008) Recent Pat. Anticancer Drug Discov. , vol.3 , pp. 31-47
    • Blum, R.1    Cox, A.D.2    Kloog, Y.3
  • 4
    • 0026619185 scopus 로고
    • The Ras/cholesterol connection: implications for Ras oncogenicity
    • Cox A.D., Der C.J. The Ras/cholesterol connection: implications for Ras oncogenicity. Crit. Rev. Oncog. 1992, 3.
    • (1992) Crit. Rev. Oncog. , vol.3
    • Cox, A.D.1    Der, C.J.2
  • 6
    • 34249100668 scopus 로고    scopus 로고
    • Stopping Ras in its tracks
    • Der C.J., Van Dyke T. Stopping Ras in its tracks. Cell 2007, 129:855-857.
    • (2007) Cell , vol.129 , pp. 855-857
    • Der, C.J.1    Van Dyke, T.2
  • 7
    • 36248934768 scopus 로고    scopus 로고
    • Interactions of Ras proteins with the plasma membrane and their roles in signaling
    • Eisenberg S., Henis Y.I. Interactions of Ras proteins with the plasma membrane and their roles in signaling. Cell. Signal. 2008, 20:31-39.
    • (2008) Cell. Signal. , vol.20 , pp. 31-39
    • Eisenberg, S.1    Henis, Y.I.2
  • 8
    • 33846205171 scopus 로고    scopus 로고
    • A Ras inhibitor tilts the balance between rac and rho and blocks PI3-kinase-dependent glioblastoma cell migration
    • Goldberg L., Kloog Y. A Ras inhibitor tilts the balance between rac and rho and blocks PI3-kinase-dependent glioblastoma cell migration. Cancer Res. 2006, 66:11709-11717.
    • (2006) Cancer Res. , vol.66 , pp. 11709-11717
    • Goldberg, L.1    Kloog, Y.2
  • 10
    • 2942692037 scopus 로고    scopus 로고
    • + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    • + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 2004, 199:1479-1489.
    • (2004) J. Exp. Med. , vol.199 , pp. 1479-1489
    • Herman, A.E.1    Freeman, G.J.2    Mathis, D.3    Benoist, C.4
  • 11
    • 69049116053 scopus 로고    scopus 로고
    • Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    • Ilarregui J.M., Croci D.O., Bianco G.A., Toscano M.A., Salatino M., Vermeulen M.E., Geffner J.R., Rabinovich G.A. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat. Immunol. 2009, 10:981-991.
    • (2009) Nat. Immunol. , vol.10 , pp. 981-991
    • Ilarregui, J.M.1    Croci, D.O.2    Bianco, G.A.3    Toscano, M.A.4    Salatino, M.5    Vermeulen, M.E.6    Geffner, J.R.7    Rabinovich, G.A.8
  • 12
    • 0034751768 scopus 로고    scopus 로고
    • The Ras-pathway inhibitor S, trans-trans farnesythiosalicylic acid (FTS) suppresses experimental allergic encephalomyelitis
    • Karusis, D., Abramsky, O., Grigoriadis, N., Chapman, J., Mizrachi-Koll, R., Niv, H., Kloog, Y., 2001. The Ras-pathway inhibitor S, trans-trans farnesythiosalicylic acid (FTS) suppresses experimental allergic encephalomyelitis. J. Neuroimmunol. 120, 1-9.
    • (2001) J. Neuroimmunol , vol.120 , pp. 1-9
    • Karusis, D.1    Abramsky, O.2    Grigoriadis, N.3    Chapman, J.4    Mizrachi-Koll, R.5    Niv, H.6    Kloog, Y.7
  • 14
    • 49649099238 scopus 로고    scopus 로고
    • N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells
    • Mor A., Keren G., Kloog Y., George J. N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells. Eur. J. Immunol. 2008, 38:1493-1502.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1493-1502
    • Mor, A.1    Keren, G.2    Kloog, Y.3    George, J.4
  • 15
    • 67651099098 scopus 로고    scopus 로고
    • Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice
    • Mor A., Kloog Y., Keren G., George J. Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. Eur. J. Pharmacol. 2009, 616:301-305.
    • (2009) Eur. J. Pharmacol. , vol.616 , pp. 301-305
    • Mor, A.1    Kloog, Y.2    Keren, G.3    George, J.4
  • 16
    • 23844500699 scopus 로고    scopus 로고
    • Compartmentalized signalling of Ras
    • Philips M.R. Compartmentalized signalling of Ras. Biochem. Soc. Trans. 2005, 33:657-661.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 657-661
    • Philips, M.R.1
  • 17
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.