Drug release from hydroethanolic gels. Effect of drug's lipophilicity (logP), polymer-drug interactions and solvent lipophilicity

International Journal of Pharmaceutics

Volumn 396, Issue 1-2, 2010, Pages 45-52

  Sawant, Prashant D ^a   Luu, Dewitt ^a   Ye, Rose ^a   Buchta, Richard ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Drug polymer interactions; Hydroethanolic gels; Lipophilicity of drugs; Lipophilicity of solvents; Polymer chemistry

Indexed keywords

ALCOHOL; EUDRAGIT; HYDROETHANOLIC GEL; LIDOCAINE; POLYMER; UNCLASSIFIED DRUG; ACRYLIC ACID DERIVATIVE; CELLULOSE; DRUG CARRIER; FATTY ALCOHOL; GEL; HYDROXYPROPYLCELLULOSE; ISOSTEARYL ALCOHOL; LOCAL ANESTHETIC AGENT; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; POLYMETHACRYLIC ACID DERIVATIVE; SOLVENT;

ARTICLE; DRUG RELEASE; HYDROPHILICITY; LIPOPHILICITY; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMISTRY; DRUG FORMULATION; GEL; INFRARED SPECTROSCOPY; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; SOLUBILITY;

ACRYLATES; ANESTHETICS, LOCAL; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; ETHANOL; FATTY ALCOHOLS; GELS; KINETICS; LIDOCAINE; MODELS, CHEMICAL; POLYMERS; POLYMETHACRYLIC ACIDS; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL;

EID: 77955054581     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.06.008     Document Type: Article

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