In vitro delivery of doxycycline hydrochloride based on a porous membrane-based aqueous-organic partitioning system

Journal of Controlled Release

Volumn 98, Issue 3, 2004, Pages 355-365

  Fan, Qiuxi ^a   Sirkar, Kamalesh K ^a   Wang, Yiping ^b   Michniak, Bozena ^c  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Aqueous organic partitioning; Controlled release; Doxycycline hydrochloride; Microporous and skin membranes; Patch; Suspension

Indexed keywords

CELLS; DIFFUSION; DRUG DOSAGE; ORGANIC SOLVENTS; POROUS MATERIALS; SUSPENSIONS (FLUIDS);

DOXYCYCLINE; DRUG FLUX; MINERAL OIL; SKIN PATCH;

ANTIBIOTICS;

DOXYCYCLINE; LINOLEIC ACID; POLYPROPYLENE;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CADAVER; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFUSION CHAMBER; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; FULL THICKNESS SKIN GRAFT; HYDROPHOBICITY; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PATCH CLAMP; POROSITY; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN PERMEABILITY;

ALZHEIMER DISEASE; ANIMALS; ANTI-BACTERIAL AGENTS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXYCYCLINE; DRUG DELIVERY SYSTEMS; LINOLEIC ACID; MALE; MEMBRANES, ARTIFICIAL; MICE; MICE, INBRED HRS; MINERAL OIL; OCTANOLS; PERMEABILITY; POLYPROPYLENES; SKIN ABSORPTION; SOLUTIONS;

EID: 4143064623     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.05.005     Document Type: Article

References (25)

1. Kydonieus A.L. Controlled Release Technologies: Methods, Theory and Applications. 1980;CRC Press, Boca Raton, FL
2. Langer R. New methods of drug delivery. Science. 249:1990;1527
3. A. Zaffaroni, Novel drug delivery device, U.S. Patent 3, 993, 073, 1976.
4. Farrell S., Sirkar K. A reservoir-type controlled release device using aqueous-organic partitioning and a porous membrane. J. Membr. Sci. 130:1997;265-274
5. Farrell S., Sirkar K. A mathematical model of an aqueous-organic partition-based controlled release system using microporous membranes. J. Control. Release. 61:1999;345-360
6. Farrell S., Sirkar K. Mathematical model of a hybrid dispersed network-membrane-based controlled release system. J. Control. Release. 70:2001;51-61
7. Q. Fan, unpublished data, 2004.
8. Perkins N., Heard C. In vitro dermal and transdermal delivery of doxycycline from ethanol/migliol 840 vehicles. Int. J. Pharm. 190:1999;155-164
9. Badkar A.V., Banga A.K. Electrically enhanced transdermal delivery of a macromolecule. J. Pharm. Pharmacol. 54:2002;907-912
10. Bos J.D., Meinardi M.M.H.M. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp. Dermatol. 9:2000;165-169
11. Prasad R., Sirkar K. Dispersion-free solvent extraction with microporous hollow-fiber modules. AIChE J. 44:1988;177-188
12. 2 mixtures by immobilized carbonate-glycerol membranes. Ind. Eng. Chem. Res. 38(9):1999;3489-3498
13. S. Farrell, A Controlled Release Technique Using Microporous Membranes, PhD Thesis, New Jersey Institute of Technology, 1996.
14. Sloan K.B., Beall H.D., Weimar W.R., Villanueva R. The effect of receptor phase composition on the permeability of hairless mouse skin in diffusion cell experiments. Int. J. Pharm. 73(2):1991;97-104
15. Guy R., Hadgraft J. Hadgraft J., Guy R.H. Transdermal Drug Delivery: Developmental Issues and Research Initiatives. 1989;59-82 Marcel Dekker, New York. Chap. 3
16. S.B. Kessler, E. Klein, in: W.S. Winston Ho, K.K. Sirkar, (Eds.), Membrane Handbook, Chapman & Hall, New York, 1992, Chap. 11, Kluwer Academic, Boston, 2001.
17. Libinson G.S. Doxycycline, potentiometric titration. Antibiotiki. 22(12):1977;1093-1095
18. Wilke C.R., Chang P. Correlation of diffusion coefficients in dilute solutions. AIChE J. 1(2):1955;264-270
19. Newman J.S. Electrochemical Systems. 1973;Prentice-Hall, Eaglewood Cliffs, NJ. pp. 227, Table 75-1
20. Welty J.R., Wicks C.E., Wilson E. Fundamentals of Momentum, Heat, and Mass Transfer. 2nd edition:1976;634-649 John Wiley & Sons, New York. Chap. 30
21. Godwin D.A., Michniak B.B. Influence of drug lipophilicity on terpenes as transdermal penetration enhancers. Drug Dev. Ind. Pharm. 25:1999;905-915
22. El-Kattan A.F., Asbill C.S., Michniak B.B. The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems. Int. J. Pharm. 198:2000;179-189
23. El-Kattan A.F., Asbill C.S., Kim N., Michniak B.B. The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities. Int. J. Pharm. 215:2001;229-240
24. Chattaraj S., Walker R. Smith E.W., Maibach H.I. Percutaneous Penetration Enhancers. 1995;5-15 CRC Press, Boca Raton, Florida. Chap. 1.2
25. Bogardus J.B., Blakwood R.K. Jr. Solubility of doxycycline in aqueous solution. J. Pharm. Sci. 68:1979;188-194