Mechanism of drug release from poly(L-lactic acid) matrix containing acidic or neutral drugs

Journal of Controlled Release

Volumn 60, Issue 2-3, 1999, Pages 199-209

  Miyajima, Makoto ^a   Koshika, Akiko ^a   Okada, Jun'ichi ^a   Ikeda, Masaru ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Acidic and neutral drugs; Biodegradable polymer; Diffusion controlled release; Drug dispersed matrix; Poly(L lactic acid)

Indexed keywords

GRISEOFULVIN; IBUPROFEN; INDOMETACIN; NAPROXEN; POLYLACTIC ACID; PROGESTERONE; TESTOSTERONE;

ARTICLE; CRYSTALLIZATION; DRUG DIFFUSION; DRUG RELEASE; DRUG SOLUBILITY; MODEL; PARTITION COEFFICIENT; PRIORITY JOURNAL; WATER CONTENT; X RAY DIFFRACTION;

BIODEGRADATION, ENVIRONMENTAL; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DIFFUSION; GRISEOFULVIN; HYDROGEN-ION CONCENTRATION; IBUPROFEN; INDOMETHACIN; LACTIC ACID; NAPROXEN; POLYMERS; PROGESTERONE; SOLUBILITY; TESTOSTERONE;

EID: 0032808811     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00083-8     Document Type: Article

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