메뉴 건너뛰기




Volumn 121, Issue 1-3, 2010, Pages 160-171

Overexpression of serotonin receptor and transporter mRNA in blood leukocytes of antipsychotic-free and antipsychotic-naïve schizophrenic patients: Gender differences

Author keywords

Drug free schizophrenia; Leukocytes; MRNA; Serotonin receptor and transporter

Indexed keywords

MESSENGER RNA; NEUROLEPTIC AGENT; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER;

EID: 77955054539     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2010.03.030     Document Type: Article
Times cited : (15)

References (41)
  • 1
    • 0035987340 scopus 로고    scopus 로고
    • Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms
    • Abi-Saab W., Seibyl J.P., D'Souza D.C., Karper L.P., Gueorgueva R., Abi-Dargham A., et al. Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology (Berl) 2002, 162:55-62.
    • (2002) Psychopharmacology (Berl) , vol.162 , pp. 55-62
    • Abi-Saab, W.1    Seibyl, J.P.2    D'Souza, D.C.3    Karper, L.P.4    Gueorgueva, R.5    Abi-Dargham, A.6
  • 2
    • 0033815288 scopus 로고    scopus 로고
    • Assessment of nicotinic acetylcholine receptor-mediated release of [(3)H]-norepinephrine from rat brain slices using a new 96-well format assay
    • Anderson D.J., Puttfarcken P.S., Jacobs I., Faltynek C. Assessment of nicotinic acetylcholine receptor-mediated release of [(3)H]-norepinephrine from rat brain slices using a new 96-well format assay. Neuropharmacology 2000, 39:2663-2672.
    • (2000) Neuropharmacology , vol.39 , pp. 2663-2672
    • Anderson, D.J.1    Puttfarcken, P.S.2    Jacobs, I.3    Faltynek, C.4
  • 3
    • 0038207693 scopus 로고    scopus 로고
    • Altered platelet serotonin 5-HT2A receptor density but not second messenger inositol trisphosphate levels in drug-free schizophrenic patients
    • Arranz B., Rosel P., Sarro S., Ramirez N., Duenas R., Cano R., et al. Altered platelet serotonin 5-HT2A receptor density but not second messenger inositol trisphosphate levels in drug-free schizophrenic patients. Psychiatry Res. 2003, 118:165-174.
    • (2003) Psychiatry Res. , vol.118 , pp. 165-174
    • Arranz, B.1    Rosel, P.2    Sarro, S.3    Ramirez, N.4    Duenas, R.5    Cano, R.6
  • 4
    • 35148828980 scopus 로고    scopus 로고
    • Low baseline serotonin-2A receptors predict clinical response to olanzapine in first-episode schizophrenia patients
    • Arranz B., Rosel P., San L., Ramirez N., Duenas R.M., Salavert J., et al. Low baseline serotonin-2A receptors predict clinical response to olanzapine in first-episode schizophrenia patients. Psychiatry Res. 2007, 153:103-109.
    • (2007) Psychiatry Res. , vol.153 , pp. 103-109
    • Arranz, B.1    Rosel, P.2    San, L.3    Ramirez, N.4    Duenas, R.M.5    Salavert, J.6
  • 5
    • 33750804719 scopus 로고    scopus 로고
    • Serotonin transporter characteristics in lymphocytes and platelets of male aggressive schizophrenia patients compared to non-aggressive schizophrenia patients
    • Barkan T., Peled A., Modai I., Barak P., Weizman A., Rehavi M. Serotonin transporter characteristics in lymphocytes and platelets of male aggressive schizophrenia patients compared to non-aggressive schizophrenia patients. Eur. Neuropsychopharmacol. 2006, 16:572-579.
    • (2006) Eur. Neuropsychopharmacol. , vol.16 , pp. 572-579
    • Barkan, T.1    Peled, A.2    Modai, I.3    Barak, P.4    Weizman, A.5    Rehavi, M.6
  • 6
    • 33745699119 scopus 로고    scopus 로고
    • Characterization of the serotonin transporter in lymphocytes and platelets of schizophrenia patients treated with atypical or typical antipsychotics compared to healthy individuals
    • Barkan T., Peled A., Modai I., Weizman A., Rehavi M. Characterization of the serotonin transporter in lymphocytes and platelets of schizophrenia patients treated with atypical or typical antipsychotics compared to healthy individuals. Eur. Neuropsychopharmacol. 2006, 16:429-436.
    • (2006) Eur. Neuropsychopharmacol. , vol.16 , pp. 429-436
    • Barkan, T.1    Peled, A.2    Modai, I.3    Weizman, A.4    Rehavi, M.5
  • 7
    • 77955050255 scopus 로고
    • Thoughts on the present theory of schizophrenia, with reference to concepts of constitutional pathology.
    • Bleuler M. Thoughts on the present theory of schizophrenia, with reference to concepts of constitutional pathology. Wien. Z. Nervenheilkd. Grenzgeb 1953, 7:255-270.
    • (1953) Wien. Z. Nervenheilkd. Grenzgeb , vol.7 , pp. 255-270
    • Bleuler, M.1
  • 9
    • 0035116315 scopus 로고    scopus 로고
    • Pindolol augmentation in aggressive schizophrenic patients: a double-blind crossover randomized study
    • Caspi N., Modai I., Barak P., Waisbourd A., Zbarsky H., Hirschmann S., et al. Pindolol augmentation in aggressive schizophrenic patients: a double-blind crossover randomized study. Int. Clin. Psychopharmacol. 2001, 16:111-115.
    • (2001) Int. Clin. Psychopharmacol. , vol.16 , pp. 111-115
    • Caspi, N.1    Modai, I.2    Barak, P.3    Waisbourd, A.4    Zbarsky, H.5    Hirschmann, S.6
  • 10
    • 37349083825 scopus 로고    scopus 로고
    • Long-term estrogen therapy and 5-HT2A receptor binding in postmenopausal women: a single photon emission tomography (SPET) study
    • Compton J., Travis M.J., Norbury R., Erlandsson K., van Amelsvoort T., Daly E., et al. Long-term estrogen therapy and 5-HT2A receptor binding in postmenopausal women: a single photon emission tomography (SPET) study. Horm. Behav. 2008, 53:61-68.
    • (2008) Horm. Behav. , vol.53 , pp. 61-68
    • Compton, J.1    Travis, M.J.2    Norbury, R.3    Erlandsson, K.4    van Amelsvoort, T.5    Daly, E.6
  • 11
    • 0030592323 scopus 로고    scopus 로고
    • Decreased frontal cortical serotonin2A receptors in schizophrenia
    • Dean B., Hayes W. Decreased frontal cortical serotonin2A receptors in schizophrenia. Schizophr. Res. 1996, 21:133-139.
    • (1996) Schizophr. Res. , vol.21 , pp. 133-139
    • Dean, B.1    Hayes, W.2
  • 12
    • 0019510058 scopus 로고
    • Increased whole blood serotonin concentrations in chronic schizophrenic patients
    • DeLisi L.E., Neckers L.M., Weinberger D.R., Wyatt R.J. Increased whole blood serotonin concentrations in chronic schizophrenic patients. Arch. Gen. Psychiatry 1981, 38:647-650.
    • (1981) Arch. Gen. Psychiatry , vol.38 , pp. 647-650
    • DeLisi, L.E.1    Neckers, L.M.2    Weinberger, D.R.3    Wyatt, R.J.4
  • 13
    • 33846235101 scopus 로고    scopus 로고
    • Influence of clozapine on platelet serotonin, monoamine oxidase and plasma serotonin levels
    • Ertugrul A., Ucar G., Basar K., Demir B., Yabanoglu S., Ulug B. Influence of clozapine on platelet serotonin, monoamine oxidase and plasma serotonin levels. Psychiatry Res. 2007, 149:49-57.
    • (2007) Psychiatry Res. , vol.149 , pp. 49-57
    • Ertugrul, A.1    Ucar, G.2    Basar, K.3    Demir, B.4    Yabanoglu, S.5    Ulug, B.6
  • 15
    • 0016670454 scopus 로고
    • Elevated blood serotonin concentrations in unmediated chronic schizophrenic patients: a preliminary study
    • Garelis E., Gillin J.C., Wyatt R.J., Neff N. Elevated blood serotonin concentrations in unmediated chronic schizophrenic patients: a preliminary study. Am. J. Psychiatry 1975, 132:184-186.
    • (1975) Am. J. Psychiatry , vol.132 , pp. 184-186
    • Garelis, E.1    Gillin, J.C.2    Wyatt, R.J.3    Neff, N.4
  • 16
    • 0034715191 scopus 로고    scopus 로고
    • Platelet 5-HT(2A) receptors in schizophrenic patients with and without neuroleptic treatment
    • Govitrapong P., Chagkutip J., Turakitwanakan W., Srikiatkhachorn A. Platelet 5-HT(2A) receptors in schizophrenic patients with and without neuroleptic treatment. Psychiatry Res. 2000, 96:41-50.
    • (2000) Psychiatry Res. , vol.96 , pp. 41-50
    • Govitrapong, P.1    Chagkutip, J.2    Turakitwanakan, W.3    Srikiatkhachorn, A.4
  • 18
    • 0030825125 scopus 로고    scopus 로고
    • Alterations in the cortical serotonergic system in schizophrenia: a postmortem study
    • Gurevich E.V., Joyce J.N. Alterations in the cortical serotonergic system in schizophrenia: a postmortem study. Biol. Psychiatry 1997, 42:529-545.
    • (1997) Biol. Psychiatry , vol.42 , pp. 529-545
    • Gurevich, E.V.1    Joyce, J.N.2
  • 19
    • 0030897885 scopus 로고    scopus 로고
    • Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics
    • Hernandez I., Sokolov B.P. Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics. Mol. Psychiatry 1997, 2:57-64.
    • (1997) Mol. Psychiatry , vol.2 , pp. 57-64
    • Hernandez, I.1    Sokolov, B.P.2
  • 20
    • 0242600079 scopus 로고    scopus 로고
    • Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    • Holmes A., Yang R.J., Lesch K.P., Crawley J.N., Murphy D.L. Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 2003, 28:2077-2088.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 2077-2088
    • Holmes, A.1    Yang, R.J.2    Lesch, K.P.3    Crawley, J.N.4    Murphy, D.L.5
  • 21
    • 33645031288 scopus 로고    scopus 로고
    • Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population
    • Ikeda M., Iwata N., Kitajima T., Suzuki T., Yamanouchi Y., Kinoshita Y., et al. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology 2006, 31:866-871.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 866-871
    • Ikeda, M.1    Iwata, N.2    Kitajima, T.3    Suzuki, T.4    Yamanouchi, Y.5    Kinoshita, Y.6
  • 23
    • 1542776092 scopus 로고    scopus 로고
    • The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary
    • Kane J.M., Leucht S., Carpenter D., Docherty J.P. The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary. J. Clin. Psychiatry 2003, 64(Suppl 12):5-19.
    • (2003) J. Clin. Psychiatry , vol.64 , Issue.SUPPL. 12 , pp. 5-19
    • Kane, J.M.1    Leucht, S.2    Carpenter, D.3    Docherty, J.P.4
  • 25
    • 0032589898 scopus 로고    scopus 로고
    • Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects
    • Lewis R., Kapur S., Jones C., DaSilva J., Brown G.M., Wilson A.A., et al. Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects. Am. J. Psychiatry 1999, 156:72-78.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 72-78
    • Lewis, R.1    Kapur, S.2    Jones, C.3    DaSilva, J.4    Brown, G.M.5    Wilson, A.A.6
  • 27
    • 0029805904 scopus 로고    scopus 로고
    • Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine
    • Naylor L., Dean B., Opeskin K., Pavey G., Hill C., Keks N., et al. Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine. J. Neural Transm. 1996, 103:749-757.
    • (1996) J. Neural Transm. , vol.103 , pp. 749-757
    • Naylor, L.1    Dean, B.2    Opeskin, K.3    Pavey, G.4    Hill, C.5    Keks, N.6
  • 28
    • 22344431960 scopus 로고    scopus 로고
    • Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia
    • Newman-Tancredi A., Assie M.B., Leduc N., Ormiere A.M., Danty N., Cosi C. Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia. Int. J. Neuropsychopharmacol. 2005, 8:341-356.
    • (2005) Int. J. Neuropsychopharmacol. , vol.8 , pp. 341-356
    • Newman-Tancredi, A.1    Assie, M.B.2    Leduc, N.3    Ormiere, A.M.4    Danty, N.5    Cosi, C.6
  • 29
    • 0034640058 scopus 로고    scopus 로고
    • Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography
    • Okubo Y., Suhara T., Suzuki K., Kobayashi K., Inoue O., Terasaki O., et al. Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography. Life Sci. 2000, 66:2455-2464.
    • (2000) Life Sci. , vol.66 , pp. 2455-2464
    • Okubo, Y.1    Suhara, T.2    Suzuki, K.3    Kobayashi, K.4    Inoue, O.5    Terasaki, O.6
  • 31
    • 0034503318 scopus 로고    scopus 로고
    • Gender aspects in schizophrenia: bridging the border between social and biological psychiatry
    • Riecher-Rossler A., Hafner H. Gender aspects in schizophrenia: bridging the border between social and biological psychiatry. Acta Psychiatr. Scand. Suppl. 2000, 58-62.
    • (2000) Acta Psychiatr. Scand. Suppl. , pp. 58-62
    • Riecher-Rossler, A.1    Hafner, H.2
  • 32
    • 0028261434 scopus 로고
    • Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
    • Roth B.L., Craigo S.C., Choudhary M.S., Uluer A., Monsma F.J., Shen Y., et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther. 1994, 268:1403-1410.
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 1403-1410
    • Roth, B.L.1    Craigo, S.C.2    Choudhary, M.S.3    Uluer, A.4    Monsma, F.J.5    Shen, Y.6
  • 33
    • 36849071472 scopus 로고    scopus 로고
    • Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    • Semenova S., Geyer M.A., Sutcliffe J.G., Markou A., Hedlund P.B. Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition. Biol. Psychiatry 2008, 63:98-105.
    • (2008) Biol. Psychiatry , vol.63 , pp. 98-105
    • Semenova, S.1    Geyer, M.A.2    Sutcliffe, J.G.3    Markou, A.4    Hedlund, P.B.5
  • 34
    • 0027282204 scopus 로고
    • Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype
    • Shen Y., Monsma F.J., Metcalf M.A., Jose P.A., Hamblin M.W., Sibley D.R. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J. Biol. Chem. 1993, 268:18200-18204.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18200-18204
    • Shen, Y.1    Monsma, F.J.2    Metcalf, M.A.3    Jose, P.A.4    Hamblin, M.W.5    Sibley, D.R.6
  • 35
    • 0032440963 scopus 로고    scopus 로고
    • Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects
    • Stahl S.M. Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects. J. Affect. Disord. 1998, 51:215-235.
    • (1998) J. Affect. Disord. , vol.51 , pp. 215-235
    • Stahl, S.M.1
  • 36
    • 0029670799 scopus 로고    scopus 로고
    • Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia
    • Sumiyoshi T., Stockmeier C.A., Overholser J.C., Dilley G.E., Meltzer H.Y. Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia. Brain Res. 1996, 708:209-214.
    • (1996) Brain Res. , vol.708 , pp. 209-214
    • Sumiyoshi, T.1    Stockmeier, C.A.2    Overholser, J.C.3    Dilley, G.E.4    Meltzer, H.Y.5
  • 37
    • 0034055589 scopus 로고    scopus 로고
    • Age at onset of schizophrenia: gender differences and influence of temporal socioeconomic change
    • Takahashi S., Matsuura M., Tanabe E., Yara K., Nonaka K., Fukura Y., et al. Age at onset of schizophrenia: gender differences and influence of temporal socioeconomic change. Psychiatry Clin. Neurosci. 2000, 54:153-156.
    • (2000) Psychiatry Clin. Neurosci. , vol.54 , pp. 153-156
    • Takahashi, S.1    Matsuura, M.2    Tanabe, E.3    Yara, K.4    Nonaka, K.5    Fukura, Y.6
  • 39
    • 48649103572 scopus 로고    scopus 로고
    • Adaptation and mal-adaptation to ambient hypoxia; Andean. Ethiopian and Himalayan patterns
    • Xing G., Qualls C., Huicho L., Rivera-Ch M., Stobdan T., Slessarev M., et al. Adaptation and mal-adaptation to ambient hypoxia; Andean. Ethiopian and Himalayan patterns. PLoS ONE 2008, 3:e2342.
    • (2008) PLoS ONE , vol.3
    • Xing, G.1    Qualls, C.2    Huicho, L.3    Rivera-Ch, M.4    Stobdan, T.5    Slessarev, M.6
  • 41
    • 0034698471 scopus 로고    scopus 로고
    • Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells
    • Zhukovskaya N.L., Neumaier J.F. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci. Lett. 2000, 288:236-240.
    • (2000) Neurosci. Lett. , vol.288 , pp. 236-240
    • Zhukovskaya, N.L.1    Neumaier, J.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.