Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts

International Journal of Cancer

Volumn 81, Issue 6, 1999, Pages 963-969

  Tuháčková, Zdena ^a   Sovová, Vlasta ^a   Šloncová, Eva ^a   Proud, Christopher G ^b  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; BINDING PROTEIN; ELONGATION FACTOR 1; INITIATION FACTOR 4E; PROTEIN KINASE; RAPAMYCIN; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; DRUG RESISTANCE; FIBROBLAST; HAMSTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ROUS SARCOMA ONCOVIRUS; TUMOR CELL LINE;

ANIMALS; AVIAN SARCOMA VIRUSES; CARRIER PROTEINS; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CHICKENS; CRICETINAE; GENE EXPRESSION REGULATION; GENES, SRC; PEPTIDE ELONGATION FACTOR 1; PEPTIDE ELONGATION FACTORS; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; TUMOR CELLS, CULTURED;

EID: 0033043254     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990611)81:6<963::AID-IJC20>3.0.CO;2-C     Document Type: Article

References (22)

1. BERETTA, L., GINGRAS, A.-C., SVITKIN, Y.V., HALL, M.N. and SONENBERG, N., Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J., 15, 658-664 (1996).
2. BONHAM, K. and FUJITA, D.J., Organization and analysis of the promoter region and 5'non-coding exons of the human c-src proto-oncogene. Oncogene, 8, 1973-1981 (1993).
3. BROWN, E.J. and SCHREIBER, S.L., A signalling pathway to translational control. Cell. 86, 517-520 (1996).
4. BROWN, M.T. and COOPER, J.A., Regulation, substrates and functions of Src. Biochim. biophys. Acta, 1287, 121-149 (1996).
5. BURNETT, P.E., BARROW, R.K., COHEN, N.A., SNYDER, S.H. and SABATINI, D.M., RAFT 1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. not. Acad. Sci. (Wash.), 95, 1432-1737 (1998).
6. CHUNG, J., KUO, C.J., CRABTREE, G.R. and BLENIS, J., Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70-kD S6 protein kinases. Cell, 69, 1227-1236 (1992).
7. DIAMOND, L., Two spontaneously transformed cell lines derived from the same hamster embryo culture. Int. J. Cancer, 2, 143-145 (1967).
8. DIGGLE, T.A., BLOOMBERG, G.B. and DENTON, R.M., Further characterization of the acid-soluble phosphoprotein (SDS/PAGE apparent molecular mass of 22 kDa) in rat fat cells by peptide sequencing and immuno-analysis: effects of insulin and isoprenaline. Biochem. J., 306, 135-139 (1995).
9. DIGGLE, T.A., MOULE, S.K., AVISON, M.B., FLYNN, A., FOULSTONE, E.J., PROUD, C.G. and DENTON, R.M., Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat cells. Biochem. J., 316, 447-453 (1996).
10. FADDEN, P., HAYSTEAD, T.A.J. and LAWRENCE, J.C., Identification of phosphorylation sites in the translational regulator, PHAS-1, that are controlled by insulin and rapamycin in rat adipocytes. J. biol. Chem., 272, 10240-10247 (1997).
11. FLYNN, A. and PROUD, C.G., Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor. Europ. J. Biochem., 236, 40-47 (1996).
12. HARA, K., YONEZAWA, K., KOZLOWSKI, M.T., SUGIMOTO, T., ANDRABI, K., WENG, Q.-P., KASUGA, M., NISHIMOTO, I. and AVRUCH, J., Regulation of eIF-4E BP1 phosphorylation by mTOR. J. biol. Chem., 272, 26457-26463 (1997).
13. s6k. EMBO J., 16, 3693-3704 (1997).
14. LAZARIS-KARATZAS, A., MONTINE, K.S. and SONENBERG, N., Malignant transformation by a eukaryotic initiation-factor sub-unit that binds to mRNA 5'-cap. Nature (Lond.), 345, 544-547 (1990).
15. PAUSE, A., BELSHAM, G.J., GINGRAS, A.-C., DONZÉ, O., LIN, T.A., LAWRENCE, J.C., JR. and SONENBERG, N., Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (Lond.), 371, 762-767 (1994).
16. REDPATH, N.T., FOULSTONE, E.J. and PROUD, C.G., Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J., 15, 2291-2297 (1996).
17. ROUSSEAU, D., GINGRAS, A.-C., PAUSE, A. and SONENBERG, N., The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Oncogene, 13, 2415-2420 (1996).
18. SVOBODA, J., LHOTÁK, V., GERYK, J., SAULE, S., RAES, M.B. and STEHELIN, D., Characterization of exogenous proviral sequences in hamster tumour cell lines transformed by Rous sarcoma virus rescued from XC cells. Virology, 128, 195-198 (1983).
19. TUHÁČKOVÁ, Z., Staurosporine and gossypol are inhibitors of the function of peptide-elongation factor 1α from rabbit reticulocytes. Biochem. mol. cell. Biol. Int., 32, 545-554 (1994).
20. VIKLICKÝ, V., DRÁBER, P., HAŠEK, J. and BÁRTEK, J., Production and characterization of a monoclonal anti-tubulin antibody. J. Cell Biol. Int. Rep., 6, 731-735 (1982).
21. S6k. Mol. cell. Biol., 17, 5426-5436 (1997).
22. WEST, M.J., STONELEY, M. and WILLIS, A.E., Translational induction of the c-mvc oncogene via activation of the FRAP/TOR signalling pathway. Oncogene. 17, 769-780 (1998).