IFN-γ generates maturation-arrested dendritic cells that induce T cell hyporesponsiveness independent of Foxp3+ T-regulatory cell generation

Immunology Letters

Volumn 132, Issue 1-2, 2010, Pages 31-37

  Rojas, Darling ^a,b   Krishnan, Ravi ^a,b  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Dendritic cells; Foxp3+; Immunoglobulin like transcripts; Interferon ; T cells; Transplantation

Indexed keywords

CD83 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA G ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR RELB; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ALLOIMMUNITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL CYCLE ARREST; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; UPREGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; METABOLISM;

CELL DIFFERENTIATION; CELL PROLIFERATION; DENDRITIC CELLS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERFERON-GAMMA; T-LYMPHOCYTES, REGULATORY;

EID: 77955012798     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.05.003     Document Type: Article

References (42)

1. Vieira P.L., De Jong E.C., Wierenga E.A., Kapsenberg M.L., Kalinski P. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol 2000, 164:4507-4512.
2. Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukocyte Biol 2004, 75:163-189.
3. Wood K.J, Sawitzki B. Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol 2006, 27:183-187.
4. Ferber I.A., Brocke S., Taylor-Edwards C., Ridgway W., Dinisco C., Steinman L., et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 1996, 156:5-7.
5. Chu C.Q., Wittmer S., Dalton D.K. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 2000, 192:123-128.
6. Manoury-Schwartz B., Chiocchia G., Bessis N., Abehsira-Amar O., Batteux F., Muller S., et al. High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J Immunol 1997, 158:5501-5506.
7. Vermeire K., Heremans H., Vandeputte M., Huang S., Billiau A., Matthys P. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol 1997, 158:5507-5513.
8. Saleem S., Konieczny B.T., Lowry R.P., Baddoura F.K., Lakkis F.G. Acute rejection of vascularized heart allografts in the absence of IFNgamma. Transplantation 1996, 62:1908-1911.
9. + T cells, interferon-gamma, and CTLA4. J Clin Invest 1998, 101:2446-2455.
10. Konieczny B.T., Dai Z., Elwood E.T., Saleem S., Linsley P.S., Baddoura F.K., et al. IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998, 160:2059-2064.
11. + regulatory T cells. Eur J Immunol 2008, 38:2512-2527.
12. Rongcun Y., Maes H., Corsi M., Dellner F., Wen T., Kiessling R. Interferon gamma impairs the ability of monocyte-derived dendritic cells to present tumour-specific and allo-specific antigens and reduces their expression of CD1A, CD80 AND CD4. Cytokine 1998, 10:747-755.
13. Delneste Y., Charbonnier P., Herbault N., Magistrelli G., Caron G., Bonnefoy J.Y., et al. Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages. Blood 2003, 101:143-150.
14. + T cells to CTLA4-Ig and interleukin-10 mediated inhibition in an allogeneic dendritic cell-mixed lymphocyte reaction. Immunology 2006, 118:216-223.
15. Neumann M., Fries H., Scheicher C., Keikavoussi P., Kolb-Maurer A., Brocker E., et al. Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells. Blood 2000, 95:277-285.
16. Mellor A.L., Munn D.H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004, 4:762-774.
17. Allan D.S., Colonna M., Lanier L.L., Churakova T.D., Abrams J.S., Ellis S.A., et al. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. J Exp Med 1999, 189:1149-1156.
18. Le Rond S., Azema C., Krawice-Radanne I., Durrbach A., Guettier C., Carosella E.D., et al. Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/regulatory T cells. J Immunol 2006, 176:3266-3276.
19. Randolph G.J., Inaba K., Robbiani D.F., Steinman R.M., Muller W.A. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 1999, 11:753-761.
20. Bonder C.S., Davies K.V., Hosszu E.K., Finlay-Jones J.J., Hart P.H. IFN-gamma downregulates interleukin-4 functional activity on monocytes by multiple mechanisms. J Interferon Cytokine Res 2002, 22:287-293.
21. Lehtonen A., Veckman V., Nikula T., Lahesmaa R., Kinnunen L., Matikainen S., et al. Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J Immunol 2005, 175:6570-6579.
22. Nakajima H., Asai A., Okada A., Ping L., Hamajima F., Sata T., et al. Transcriptional regulation of ILT family receptors. J Immunol 2003, 171:6611-6620.
23. Bleijs D.A., Geijtenbeek T.B., Figdor C.G., van Kooyk Y. DC-SIGN and LFA-1: a battle for ligand. Trends Immunol 2001, 22:457-463.
24. + monocytes as dendritic cell precursors: diverse maturation-inducing pathways lead to common activation of NF-kappab/RelB. Crit Rev immunol 2001, 21:179-189.
25. Ebner S., Ratsinger G., Krosbasher B., Schmuth M., Weiss A., Reider D., et al. Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation and is further enhanced by IL-4. J Immunol 2001, 166:633-641.
26. Wenner C.A., Guler M.L., Macatonia S.E., O'Garra A., Murphy K.M. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J Immunol 1996, 156:1442-1447.
27. Ahn H.J., Maruo S., Tomura M., Mu J., Hamaoka T., Nakanishi K., et al. A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. J Immunol 1997, 159:2125-2131.
28. + T cells. J Immunol 1995, 154:5071-5079.
29. + regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy. Transplantation 2008, 86:578-589.
30. + Tregs. J Clin Invest 2006, 116:2434-2441.
31. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
32. Schwartz R.H. T cell anergy. Annu Rev Immunol 2003, 21:305-334.
33. Essery G., Feldmann M., Lamb J.R. Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. Immunology 1988, 64:413-417.
34. Roncarolo M.G., Bacchetta R., Bordignon C., Narula S., Levings M.K. Type 1 T regulatory cells. Immunol Rev 2001, 182:68-79.
35. Wells A.D., Walsh M.C., Bluestone J.A., Turka L.A. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest 2001, 108:895-903.
36. Lefebvre S., Adrian F., Moreau P., Gourand L., Dausset J., Berrih-Aknin S., et al. Modulation of HLA-G expression in human thymic and amniotic epithelial cells. Hum Immunol 2000, 61:1095-1101.
37. Beutelspacher S.C., Tan P.H., McClure M.O., Larkin D.F., Lechler R.I., George A.J. Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses. Am J Transplant 2006, 6:1320-1330.
38. Le Friec G., Laupeze B., Fardel O., Sebti Y., Pangault C., Guillox V., et al. Soluble HLA-G inhibits human dendritic cell-triggered allogeneic T-cell proliferation without altering dendritic differentiation and maturation processes. Hum Immunol 2003, 64:752-761.
39. Terness P., Chuang J.J., Bauer T., Jiga L., Opelz G. Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?. Blood 2005, 105(6):2480-2486.
40. Munn D.H., Sharma M.D., Lee J.R., Jhaver K.G., Johnson T.S., Keskin B.M., et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002, 297:1867-1870.
41. Osada T., Clay T.M., Woo C.Y., Morse M.A., Lyerly H.K. Dendritic cell-based immunotherapy. Int Rev Immunol 2006, 25:377-413.
42. Frasca L., Nasso M., Spensieri F., Fedele G., Palazzo R., Malavasi F., et al. IFN-gamma arms human dendritic cells to perform multiple effector functions. J Immunol 2008, 180:1471-1481.