Insights from studying the mutation-induced allostery in the M2 proton channel by molecular dynamics

Protein Engineering, Design and Selection

Volumn 23, Issue 8, 2010, Pages 663-666

  Wang, Jing Fang ^a,b,c   Chou, Kuo Chen ^a,c  

^a Shanghai Jiao Tong University   (China)

^b SHANGHAI CENTER FOR BIOINFORMATION TECHNOLOGY   (China)

^c GORDON LIFE SCIENCE INSTITUTE   (United States)

Author keywords

drug resistance; four helix bundle; influenza A virus; M2 proton channel; molecular dynamics

Indexed keywords

DYNAMICS; MOLECULAR DYNAMICS; PROTONS;

DRUG RESISTANCE; HELIX BUNDLE; INFLUENZA A VIRUS; M2 PROTON CHANNEL; PROTON CHANNELS;

VIRUSES;

PROTON PUMP; RIMANTADINE; M2 PROTEIN, INFLUENZA A VIRUS; MATRIX PROTEIN;

ALLOSTERISM; ARTICLE; DNA HELIX; DRUG BINDING; DRUG EFFICACY; INFLUENZA VIRUS A; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTON TRANSPORT; SIMULATION; ANTIVIRAL RESISTANCE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY;

DRUG RESISTANCE, VIRAL; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; RIMANTADINE; VIRAL MATRIX PROTEINS;

EID: 77954964960     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq040     Document Type: Article

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