Solution structure of Ca2+-calmodulin reveals flexible hand-like properties of its domains

Nature Structural Biology

Volumn 8, Issue 11, 2001, Pages 990-997

  Chou, James J ^a   Li, Shipeng ^b   Klee, Claude B ^b   Bax, Ad ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALMODULIN;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENERGY TRANSFER; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE;

ANIMALS; APOPROTEINS; BINDING SITES; CALCIUM; CALMODULIN; CRYSTALLOGRAPHY, X-RAY; EF HAND MOTIFS; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLIABILITY; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; THERMODYNAMICS; XENOPUS;

EID: 0034753415     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb1101-990     Document Type: Article

References (50)

1. Molecular and structural basis of target recognition by calmodulin
2. Calmodulin: A prototypical calcium sensor
3. Structure of calmodulin refined at 2.2 Å resolution
4. Carp muscle calcium-binding protein. II. Structure determination and general description
5. Solution structure of calmodulin-W-7 complex: The basis of diversity in molecular recognition
6. Redistribution and loss of side chain entropy upon formation of a calmodulin-peptide complex
7. 15N relaxation using inverse detected two-dimensional NMR spectroscopy: The central helix is flexible
8. Solution structure of a calmodulin-target peptide complex by multidimensional NMR
9. Target enzyme recognition by calmodulin: 2.4 Å structure of a calmodulin-peptide complex
10. Modulation of calmodulin plasticity in molecular recognition on the basis of X-ray structures
11. 15N-NMR relaxation measurements
12. Solution structure of calcium-free calmodulin
13. Calcium-induced conformational transition revealed by the solution structure of apo calmodulin
14. Calcium-induced structural-changes and domain autonomy in calmodulin
15. Structure of the calcium regulatory muscle protein troponin-C at 2.8-Å resolution
16. 2+-bound calmodulin: An analysis of disorder and implications for functionally relevant plasticity
17. 13C resonance assignments of calmodulin in solution by heteronuclear multidimensional NMR-spectroscopy
18. Defining long range order in NMR structure determination from the dependence of heteronuclear relaxation times on rotational diffusion anisotropy
19. Validation of protein structure from anisotropic carbonyl chemical shifts in a dilute liquid crystalline phase
20. R-factor free R, and complete cross-validation for dipolar coupling refinement of NMR structures
21. Bicelle-based liquid crystals for NMR-measurement of dipolar couplings at acidic and basic pH values
22. Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions
23. Calmodulin structure refined at 1.7 A resolution
24. Study of conformational rearrangement and refinement of structural homology models by the use of dipolar couplings
25. Accurate modeling of protein conformation by automatic segment matching
26. The NMR structure of a DNA dodecamer in an aqueous dilute liquid crystalline phase
27. What is the average conformation of T4 lysozyme in solution? A domain orientation study using dipolar couplings measured by solution NMR
28. Prediction of sterically induced alignment in a dilute liquid crystalline phase: Aid to protein structure determination by NMR
29. Structure of the regulatory domain of scallop myosin at 2 A resolution: Implications for regulation
30. The structure of a calmodulin mutant with a deletion in the central helix: Implications for molecular recognition and protein binding
31. Substitution of the methionine residues of calmodulin with the unnatural amino acid analogs ethionine and norleucine: Biochemical and spectroscopic studies
32. NCγ couplings
33. Structural dynamics in the C-terminal domain of calmodulin at low calcium levels
34. Structural and dynamic analysis of residual dipolar coupling data for proteins
35. Orienting domains in proteins using dipolar couplings measured by liquid-state NMR: Differences in solution and crystal forms of maltodextrin binding protein loaded with β-cyclodextrin
36. Diversity of conformational states and changes within the EF-hand protein superfamily
37. 15N spectra of larger proteins: Heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin
38. Protein side chain rotamers from dipolar couplings in a liquid crystalline phase
39. 13C' dipolar couplings in medium sized proteins
40. Evaluation of cross-correlation effects and measurement of one-bond couplings in proteins with short transverse relaxation times
41. 1H dipolar couplings in weakly aligned proteins
42. Measurement of homonuclear and hteronuclear J-couplings from quantitative J-correlation
43. NMRPipe - A multidimensional spectral processing system based on Unix pipes
44. Determination of relative N-H-N N-C′, Cα-C′, and Cα-Hα effective bond lengths in a protein by NMR in a dilute liquid crystalline phase
45. Improvements and extensions in the conformational database potential for the refinement of NMR and X-ray structures of proteins and nucleic acids
46. Improving the packing and accuracy of NMR structures with a pseudopotential for the radius of gyration
47. MOLMOL: A program for display and analysis of macromolecular structures
48. PROCHECK: A program to check the stereochemical quality of protein structures