Intravitreal l-Arginine injection reverses the retinal arteriolar vasoconstriction that occurs after experimental acute branch retinal vein occlusion

Experimental Eye Research

Volumn 91, Issue 2, 2010, Pages 205-210

  Mendrinos, E ^a   Petropoulos, I K ^a   Mangioris, G ^a   Papadopoulou, D N ^a   Pournaras, C J ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Branch retinal vein occlusion; L Arginine; Retinal arteriolar diameter; Retinal vessel analyzer

Indexed keywords

ARGININE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY DIAMETER; ARTICLE; BRANCH RETINAL VEIN OCCLUSION; CONTROLLED STUDY; DRUG MECHANISM; MICROINJECTION; MINIPIG; NONHUMAN; PRIORITY JOURNAL; RETINA ARTERY; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ARGININE; ARTERIOLES; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; INJECTIONS; MICROINJECTIONS; RETINAL ARTERY; RETINAL VEIN OCCLUSION; SWINE; SWINE, MINIATURE; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS; VITREOUS BODY;

EID: 77954959230     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.05.002     Document Type: Article

References (48)

1. Adams M.R., McCredie R., Jessup W., Robinson J., Sullivan D., Celermajer D.S. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis 1997, 129:261-269.
2. Baydoun A.R., Emery P.W., Pearson J.D., Mann G.E. Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells. Biochem. Biophys. Res. Commun. 1990, 173:940-948.
3. Beauchemin M.L. The fine structure of the pig's retina. Albrecht Von Graefes Arch. Klin Exp. Ophthalmol. 1974, 190:27-45.
4. Bloodworth J.M., Gutgesell H.P., Engerman R.L. Retinal vasculature of the pig. Light and electron microscope studies. Exp. Eye Res. 1965, 4:174-178.
5. Bode-Boger S.M., Boger R.H., Alfke H., Heinzel D., Tsikas D., Creutzig A., Alexander K., Frolich J.C. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996, 93:85-90.
6. Boger R.H., Bode-Boger S.M., Thiele W., Creutzig A., Alexander K., Frolich J.C. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J. Am. Coll. Cardiol. 1998, 32:1336-1344.
7. Brazitikos P.D., Pournaras C.J., Munoz J.L., Tsacopoulos M. Microinjection of L-lactate in the preretinal vitreous induces segmental vasodilation in the inner retina of miniature pigs. Invest. Ophthalmol. Vis. Sci. 1993, 34:1744-1752.
8. Clarkson P., Adams M.R., Powe A.J., Donald A.E., McCredie R., Robinson J., McCarthy S.N., Keech A., Celermajer D.S., Deanfield J.E. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J. Clin. Invest. 1996, 97:1989-1994.
9. Creager M.A., Gallagher S.J., Girerd X.J., Coleman S.M., Dzau V.J., Cooke J.P. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 1992, 90:1248-1253.
10. Dallinger S., Sieder A., Strametz J., Bayerle-Eder M., Wolzt M., Schmetterer L. Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans. Am. J. Physiol. Endocrinol. Metab. 2003, 284:E1106-E1111.
11. Delles C., Michelson G., Harazny J., Oehmer S., Hilgers K.F., Schmieder R.E. Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke 2004, 35:1289-1293.
12. Donati G., Pournaras C.J., Munoz J.L., Poitry S., Poitry-Yamate C.L., Tsacopoulos M. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest. Ophthalmol. Vis. Sci. 1995, 36:2228-2237.
13. Donati G., Pournaras C.J., Pizzolato G.P., Tsacopoulos M. Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest. Ophthalmol. Vis. Sci. 1997, 38:1450-1457.
14. Donati G., Pournaras C.J., Tsacopoulos M. Effect of nitroprusside on arteriolar constriction after retinal branch vein occlusion. Invest. Ophthalmol. Vis. Sci. 1998, 39:1910-1917.
15. Dorner G.T., Garhofer G., Kiss B., Polska E., Polak K., Riva C.E., Schmetterer L. Nitric oxide regulates retinal vascular tone in humans. Am. J. Physiol. Heart Circ. Physiol. 2003, 285:H631-H636.
16. Drexler H., Zeiher A.M., Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991, 338:1546-1550.
17. Dubois-Rande J.L., Zelinsky R., Chabrier P.E., Castaigne A., Geschwind H., Adnot S. L-arginine improves endothelium-dependent relaxation of conductance and resistance coronary arteries in coronary artery disease. J. Cardiovasc. Pharmacol. 1992, 20(Suppl. 12):S211-S213.
18. Fukumoto Y., Urabe Y., Kubo T., Kaku T., Egashira K., Shimokawa H., Takeshita A. Augmented vasodilator response to L-arginine after coronary angioplasty may attenuate restenosis. Heart Vessels 2002, 16:171-174.
19. Garhofer G., Zawinka C., Resch H., Menke M., Schmetterer L., Dorner G.T. Effect of intravenous administration of sodium-lactate on retinal blood flow in healthy subjects. Invest. Ophthalmol. Vis. Sci. 2003, 44:3972-3976.
20. Garhofer G., Resch H., Lung S., Weigert G., Schmetterer L. Intravenous administration of L-arginine increases retinal and choroidal blood flow. Am. J. Ophthalmol. 2005, 140:69-76.
21. Giugliano D., Marfella R., Verrazzo G., Acampora R., Coppola L., Cozzolino D., D'Onofrio F. The vascular effects of L-Arginine in humans. The role of endogenous insulin. J. Clin. Invest. 1997, 99:433-438.
22. Goldstein I.M., Ostwald P., Roth S. Nitric oxide: a review of its role in retinal function and disease. Vis. Res. 1996, 36:2979-2994.
23. Goureau O., Hicks D., Courtois Y., De Kozak Y. Induction and regulation of nitric oxide synthase in retinal Muller glial cells. J. Neurochem. 1994, 63:310-317.
24. Hecker M., Sessa W.C., Harris H.J., Anggard E.E., Vane J.R. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. USA 1990, 87:8612-8616.
25. Jeppesen P., Sanye-Hajari J., Bek T. Increased blood pressure induces a diameter response of retinal arterioles that increases with decreasing arteriolar diameter. Invest. Ophthalmol. Vis. Sci. 2007, 48:328-331.
26. Kohner E.M., Dollery C.T., Shakib M., Henkind P., Paterson J.W., De Oliveira L.N., Bulpitt C.J. Experimental retinal branch vein occlusion. Am. J. Ophthalmol. 1970, 69:778-825.
27. Lauer T., Kleinbongard P., Rath J., Schulz R., Kelm M., Rassaf T. L-arginine preferentially dilates stenotic segments of coronary arteries thereby increasing coronary flow. J. Intern. Med. 2008, 264:237-244.
28. Liu S.X., Chiou G.C., Varma R.S. Improvement of retinal functions after ischemia with L-arginine and its derivatives. J. Ocul. Pharmacol. Ther. 1995, 11:261-265.
29. Liu S.X., Xuan B.O., Chen Z., Varma R.S., Chiou G.C. Nitric oxide donors: effects of S-nitrosoglutathione and 4-phenyl-3-furoxancarbonitrile on ocular blood flow and retinal function recovery. J. Ocul. Pharmacol. Ther. 1997, 13:105-114.
30. Mendrinos E., Petropoulos I.K., Mangioris G., Papadopoulou D.N., Stangos A.N., Pournaras C.J. Lactate-induced retinal arteriolar vasodilation implicates neuronal nitric oxide synthesis in minipigs. Invest. Ophthalmol. Vis. Sci. 2008, 49:5060-5066.
31. Moncada S., Higgs A. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 1993, 329:2002-2012.
32. Pemp B., Weigert G., Karl K., Petzl U., Wolzt M., Schmetterer L., Garhofer G. Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers. Diabetes Care 2009, 32:1536-1541.
33. Polak K., Dorner G., Kiss B., Polska E., Findl O., Rainer G., Eichler H.G., Schmetterer L. Evaluation of the Zeiss retinal vessel analyser. Br. J. Ophthalmol. 2000, 84:1285-1290.
34. Polak K., Luksch A., Frank B., Jandrasits K., Polska E., Schmetterer L. Regulation of human retinal blood flow by endothelin-1. Exp. Eye Res. 2003, 76:633-640.
35. Pollock J.S., Forstermann U., Mitchell J.A., Warner T.D., Schmidt H.H., Nakane M., Murad F. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc. Natl. Acad. Sci. U S A 1991, 88:10480-10484.
36. 2 in the retina of anesthetized miniature pigs in normoxia and hyperoxia. Exp. Eye Res. 1989, 49:347-360.
37. Pournaras C.J., Tsacopoulos M., Strommer K., Gilodi N., Leuenberger P.M. Experimental retinal branch vein occlusion in miniature pigs induces local tissue hypoxia and vasoproliferative microangiopathy. Ophthalmology 1990, 97:1321-1328.
38. Pournaras J.A., Petropoulos I.K., Munoz J.L., Pournaras C.J. Experimental retinal vein occlusion: effect of acetazolamide and carbogen (95% O2/5% CO2) on preretinal PO2. Invest. Ophthalmol. Vis. Sci. 2004, 45:3669-3677.
39. Pournaras C.J., Rungger-Brandle E., Riva C.E., Hardarson S.H., Stefansson E. Regulation of retinal blood flow in health and disease. Prog. Retin. Eye Res. 2008, 27:284-330.
40. Pournaras C.J. Retinal oxygen distribution. Its role in the physiopathology of vasoproliferative microangiopathies. Retina 1995, 15:332-347.
41. Pow D.V., Crook D.K. Immunocytochemical analysis of the transport of arginine analogues into nitrergic neurons and other cells in the retina and pituitary. Cell Tissue Res. 1997, 290:501-514.
42. Rector T.S., Bank A.J., Mullen K.A., Tschumperlin L.K., Sih R., Pillai K., Kubo S.H. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996, 93:2135-2141.
43. Riva C.E., Grunwald J.E., Sinclair S.H., Petrig B.L. Blood velocity and volumetric flow rate in human retinal vessels. Invest. Ophthalmol. Vis. Sci. 1985, 26:1124-1132.
44. Schmetterer L., Polak K. Role of nitric oxide in the control of ocular blood flow. Prog. Retin. Eye Res. 2001, 20:823-847.
45. Schmetterer L., Findl O., Fasching P., Ferber W., Strenn K., Breiteneder H., Adam H., Eichler H.G., Wolzt M. Nitric oxide and ocular blood flow in patients with IDDM. Diabetes 1997, 46:653-658.
46. Seifertl B.U., Vilser W. Retinal Vessel Analyzer (RVA)-design and function. Biomed. Tech. (Berl) 2002, 47(Suppl. 1 Pt 2):678-681.
47. Stangos A.N., Petropoulos I.K., Pournaras J.A., Mendrinos E., Pournaras C.J. The vasodilatory effect of juxta-arteriolar microinjection of endothelinA receptor inhibitor in healthy and acute branch retinal vein occlusion minipig retinas. Invest. Ophthalmol. Vis. Sci. 2010, 51:2185-2190.
48. Vilser W., Nagel E., Lanzl I. Retinal Vessel Analysis-new possibilities. Biomed. Tech. (Berl) 2002, 47(Suppl. 1 Pt 2):682-685.