Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 6 47-6, 2003, Pages

  Dallinger, Susanne ^a   Sieder, Anna ^a   Strametz, Jeanette ^a   Bayerle Eder, Michaela ^a   Wolzt, Michael ^a   Schmetterer, Leopold ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b Dept of Clinical Pharmacology ^*  (Austria)

Author keywords

Nitric oxide; Ocular blood flow; Renal plasma flow

Indexed keywords

4 AMINOHIPPURIC ACID; ARGININE; DEXTRO ARGININE; GLUCOSE; INSULIN; INULIN; PLACEBO;

4 AMINOHIPPURIC ACID CLEARANCE; ADULT; AMINO ACID TRANSPORT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOPPLER FLOWMETER; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG POTENTIATION; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INTERFEROMETRY; INULIN CLEARANCE; KIDNEY BLOOD FLOW; MALE; NORMAL HUMAN; OPHTHALMIC ARTERY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA BLOOD FLOW; STEREOSPECIFICITY; VASODILATATION;

EID: 0037502855     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00292.2002     Document Type: Article

References (24)

1. Baron AD. Hemodynamic actions of insulin. Am J Physiol Endocrinol Metab 267: E187-E202, 1994.
2. Bode-Böger S, Böger R, Creutzig A, Tsikas D, Gutzki F, Alexander K, and Frölich J. L-Arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin Sci (Colch) 87: 303-310, 1994.
3. Bogle RG, Baydoun AR, Pearson JD, and Mann GE. Regulation of L-arginine transport and nitric oxide release in superfused porcine aortic endothelial cells. J Physiol 490: 229-241, 1996.
4. Chowienczyk P and Ritter J. Arginine: NO more than a simple amino acid? Lancet 350: 901-902, 1997.
5. Contreras R, Fuentes O, Mann GE, and Sobrevia L. Diabetes and insulin-induced stimulation of L-arginine transport and nitric oxide synthesis in rabbit isolated gastric glands. J Physiol 498: 787-796, 1997.
6. Giugliano D, Marfella R, Verrazzo G, Acampora R, Coppola L, Cozzolino D, and D'Onofrio F. The vascular effects of L-arginine in humans. The role of endogenous insulin. J Clin Invest 99: 433-438, 1997.
7. Hishikawa K, Nakaki T, Tsuda M, Esumi H, Ohshima H, Suzuki H, Saruta T, and Kato R. Effect of L-arginine administration on hemodynamics and nitric oxide release in man. Jpn Heart J 33: 41-48, 1992.
8. Imaizumi T, Hirooka Y, Masaki H, Harada S, Nonohara N, Tagawa T, and Takeshita A. Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension 20: 511-517, 1992.
9. Kharitonov SA, Lubec G, Lubec B, Hjelm M, and Barnes PJ. L-Arginine increases exhaled nitric oxide in normal human subjects. Clin Sci (Colch) 88: 135-139, 1995.
10. Lieb WE, Cohen SM, Merton DA, Shields JA, Mitchell DG, and Goldberg BB. Color Doppler imaging of the eye and the orbit. Arch Ophthalmol 109: 527-531, 1991.
11. MacAllister RJ, Calver AL, Collier J, Edwards MCB, Herreros B, Nussey SS, and Vallance P. Vascular and hormonal response to arginine: provision of substrate for nitric oxide or non-specific effect? Clin Sci (Colch) 89: 183-190, 1995.
12. Paolisso G, Tagliamonte MR, Marfella R, Verrazzo G, D'Onfrio F, and Giugliano D. L-Arginine but not D-arginine stimulates insulin-mediated glucose uptake. Metabolism 46: 1068-1073, 1997.
13. Scherrer U, Randin D, Vollenweider P, Vollenweider L, and Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 94: 2511-2515, 1994.
14. Schmetterer L, Dallinger S, Findl O, Strenn K, Graselli U, Eichler HG, and Wolzt M. Noninvasive investigations of the normal ocular circulation in man. Invest Ophthalmol Vis Sci 39: 1210-1220, 1998.
15. Schmetterer L, Findl O, Fasching P, Ferber W, Strenn K, Breiteneder H, Adam H, Eichler HG, and Wolzt M. Nitric oxide and ocular blood flow in patients with IDDM. Diabetes 46: 653-658, 1997.
16. Schmetterer L, Lexer F, Unfried C, Sattmann H, and Fercher AF. Topical measurement of fundus pulsations. Opt Eng 34: 711-716, 1995.
17. Schmetterer L, Müller M, Fasching P, Diepolder C, Gallenkamp A, Zanaschka G, Findl O, Strenn K, Mensik C, Tschernko E, Eichler HG, and Wolzt M. Renal and ocular hemodynamic effects of insulin. Diabetes 46: 1868-1874, 1997.
18. Schnurr E, Lahme W, and Küppers H. Measurement of renal clearance of inulin and PAH in the steady state without urine collection. Clin Nephrol 13: 26-29, 1980.
19. Smulders R, Aarsen M, Teerlink T, DeVries P, VanKamp G, Donker A, and Stehouwer C. Hemodynamic and biochemical responses to L-arginine and L-lysine infusions in normal subjects: L-arginine-induced vasodilatation cannot be explained by non-specific effects of cationic amino acids. Clin Sci (Colch) 92: 367-374, 1997.
20. Sobrevia L, Nadal A, Yudilevich DL, and Mann GE. Activation of L-arginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells. J Physiol 490: 775-781, 1996.
21. Steinberg HO, Brechtel G, Johnson A, Fineberg N, and Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. J Clin Invest 94: 1172-1179, 1994.
22. Thams P and Capito K. L-Arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide. Eur J Endocrinol 140: 87-93, 1999.
23. Ueda S, Petrie JR, Cleland SJ, Elliott HL, and Connell JMC. Insulin vasodilatation and the "arginine paradox". Lancet 351: 959-690, 1998.
24. Wolzt M, Schmetterer L, Ferber W, Artner E, Mensik C, Eichler HG, and Krejcy K. Effect of nitric oxide-synthase inhibition on renal hemodynamics in man: reversal by L-arginine. Am J Physiol Renal Physiol 272: F178-F182, 1997.