Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity

Endocrinology

Volumn 139, Issue 6, 1998, Pages 2718-2726

  Spencer, Robert L ^a   Kim, Paul J ^a   Kalman, Brian A ^a   Cole, Michael A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; OXPRENOATE POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOSTERONE RELEASE; DRUG RECEPTOR BINDING; FACILITATION; FEEDBACK SYSTEM; HORMONAL REGULATION; HORMONE BINDING; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR UPREGULATION;

EID: 0031788718     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.6.6029     Document Type: Article

References (36)

1. Dallman MF, Akana SF, Cascio CS, Darlington DN, Jacobson L, Levin N 1987 Regulation of ACTH secretion: variations on a theme of B. Recent Prog Horm Res 43:113-173
2. de Kloet ER, Reul JMHM 1987 Feedback action and tonic influence of the corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems. Psychoneuroendocrinology 12:83-105
3. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM 1987 Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268-275
4. Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG, Evans RM 1985 Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318:635-641
5. Aronsson M, Fuxe K, Dong Y, Agnati LF, Okret S, Gustafsson J-A 1988 Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization. Proc Natl Acad Sci USA 85:9331-9335
6. Gustafsson J-A, Carlstedt-Duke J, Poellinger L, Okret S, Wikstrom A-C, Bronnegard M, Gillner M, Dong Y, Fuxe K, Cintra A, Harfstrand A, Agnati L 1987 Biochemistry, molecular biology, and physiology of the glucocorticoid receptor. Endocr Rev 8:185-234
7. Spencer RL, Young EA, Choo PH, McEwen BS 1990 Adrenal steroid type I and type II receptor binding: estimates of in vivo receptor number, occupancy, and activation with varying level of steroid. Brain Res 514:37-48
8. Funder JW, Pearce PT, Smith R, Smith AI 1988 Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 242:583-585
9. Arriza JL, Simerly RB, Swanson LW, Evans RM 1988 The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron 1:887-900
10. Akana SF, Cascio CS, Du J-Z, Levin N, Dallman MF 1986 Reset of feedback in the adrenocortical system: an apparent shift in sensitivity of adrenocorticotropin to inhibition by corticosterone between morning and evening. Endocrinology 119:2325-2332
11. Akana SF, Scribner KA, Bradbury MJ, Strack AM, Walker C-D, Dallman MF 1992 Feedback sensitivity of the rat hypothalamo-pituitary-adrenal axis and its capacity to adjust to exogenous corticosterone. Endocrinology 131:585-594
12. Bradbury MJ, Akana SF, Cascio CS, Levin N, Jacobson L, Dallman MF 1991 Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain. J Steroid Biochem Mol Biol 40:133-142
13. Bradbury MJ, Akana SF, Dallman MF 1994 Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: evidence for a nonadditive effect of combined receptor occupation. Endocrinology 134:1286-1296
14. Dallman MF, Levin N, Cascio CS, Akana SF, Jacobson L, Kuhn RW 1989 Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors. Endocrinology 124:2844-2850
15. de Kloet ER, Oitzl MS, Joels M 1993 Functional implications of brain corticosteroid receptor diversity. Cell Mol Neurobiol 13:433-455
16. Ratka A, Sutanto W, Bloemers M, de Kloet ER 1989 On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology 50:117-123
17. Weidenfeld J, Feldman S 1993 Glucocorticoid feedback regulation of adrenocortical responses to neural stimuli: role of CRF-41 and corticosteroid type I and type II receptors. Neuroendocrinology 58:49-56
18. Bradbury MJ, Cascio CS, Scribner KA, Dallman MF 1991 Stress-induced adrenocorticotropin secretion: diurnal responses and decreases during stress in the evening are not dependent on corticosterone. Endocrinology 128:680-688
19. Spencer RL, Miller AH, Moday H, Stein M, McEwen BS 1993 Diurnal differences in basal and acute stress levels of type I and type II adrenal steroid receptor activation in neural and immune tissues. Endocrinology 133:1941-1950
20. Kim PJ, Kalman BA, Cole MA, Spencer RL, Validation of the in vivo use of RU28318 and RU40555 for antagonism of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR), respectively. Program of the 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA, 1997 (Abstract 490.12)
21. Laue L, Chrousos GP, Loriaux DL, Barnes K, Munson P, Nieman L, Schaison G 1988 The antiglucocorticoid and antiprogestin steroid RU486 suppresses the adrenocorticotropin response to ovine corticotropin releasing hormone in man. J Clin Endocrinol Metab 66:290-293
22. Chou YC, Luttge WG 1988 Activated type II receptors in brain cannot rebind glucocorticoids: relationship to progesterone's antiglucocorticoid actions. Brain Res 440:67-68
23. Litwack G 1988 The glucocorticoid receptor at the protein level. Cancer Res 48:2636-2640
24. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 27:248-254
25. Jasper MS, Engeland WC 1994 Splachnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats. Neuroendocrinology 59:97-109
26. Beck CA, Estes PA, Bona BJ, Muro-Cacho CA, Nordeen SK, Edwards DP 1993 The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 133:728-740
27. Pearce BD, Pariante CM, Pisell TL, Miller AH, Mechanism of action of the glucocorticoid receptor antagonist, RU40555. Program of the 26th Annual Meeting of the Society for Neuroscience, Washington, DC, 1996, p 2013 (Abstract)
28. Van Eekelen JAM, Kiss JZ, Westphal HM, de Kloet ER 1987 Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in the rat brain. Brain Res 436:120-128
29. Trapp T, Rupprecht R, Castren M, Reul JMHM, Holsboer F 1994 Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. Neuron 13:1457-1462
30. Feldman S, Conforti N 1980 Participation of the dorsal hippocampus in the glucocorticoid feedback effect on adrenocortical activity. Neuroendocrinology 30:52-55
31. Bertagna X, Bertagna C, Luton J-P, Husson J-M, Girard F 1984 The new steroid analog RU486 inhibits glucocorticoid action in man. J Clin Endocrinol Metab 59:25-28
32. Gaillard RC, Riondel A, Muller AF, Herrmann W, Baulieu EE 1984 RU486: a steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day. Proc Natl Acad Sci USA 81:3879-3882
33. Kling MA, Demitrack MA, Whitfield HJ, Kalogeras KT, Listwak SJ, DeBellis MD, Chrousos GP, Gold PW, Brandt HA 1993 Effects of the glucocorticoid antagonist RU486 on pituitary-adrenal function in patients with anorexia nervosa and healthy volunteers: enhancement of plasma ACTH and cortisol secretion in underweight patients. Neuroendocrinology 57:1082-1091
34. Van Haarst AD, Oitzl MS, Workel JO, de Kloet ER 1996 Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity. Endocrinology 137:4935-4943
35. Dodt C, Kern W, Fehm HL, Born J 1993 Antimineralocorticoid canrenoate enhances secretory activity of the hypothalamus-pituitary-adrenocortical (HPA) axis in humans. Neuroendocrinology 58:570-574
36. Jacobson L, Sapolsky R 1993 Augmented ACTH responses to stress in adrenalectomized rats replaced with constant, physiological levels of corticosterone are partially normalized by acute increases in corticosterone. Neuroendocrinology 58:420-429