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Volumn 1, Issue 3, 2010, Pages 170-177

A Pilot Trial of Low-Dose Intravenous Abciximab and Unfractionated Heparin for Acute Ischemic Stroke: Translating GP IIb/IIIa Receptor Inhibition to Clinical Practice

Author keywords

Abciximab; Glycoprotein IIB IIIA receptor antagonists; GP IIB IIIA inhibitors; Ischemic stroke; Matching algorithm; Platelet aggregation units; Platelet function inhibition

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ALTEPLASE; GLUCOSE; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; HEPARIN; PLACEBO;

EID: 77954957785     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-010-0026-4     Document Type: Article
Times cited : (9)

References (55)
  • 1
    • 0842289222 scopus 로고    scopus 로고
    • TPA and proteolysis in the neurovascular unit
    • Lo E, Broderick JP, Moskowitz MA. tPA and proteolysis in the neurovascular unit. Stroke. 2004; 35: 354-6.
    • (2004) Stroke , vol.35 , pp. 354-356
    • Lo, E.1    Broderick, J.P.2    Moskowitz, M.A.3
  • 2
    • 34250336353 scopus 로고    scopus 로고
    • Intra-arterial therapies for acute ischemic stroke
    • Mandava P, Kent TA. Intra-arterial therapies for acute ischemic stroke. Neurology. 2007; 68: 2132-9.
    • (2007) Neurology , vol.68 , pp. 2132-2139
    • Mandava, P.1    Kent, T.A.2
  • 3
    • 77954951960 scopus 로고    scopus 로고
    • Intravenous rt-PA versus endovascular therapy for acute ischemic stroke
    • Mandava P, Suarez JI, Kent TA. Intravenous rt-PA versus endovascular therapy for acute ischemic stroke. Curr Atheroscl Rep. 2008; 40: 1803-10.
    • (2008) Curr Atheroscl Rep , vol.40 , pp. 1803-1810
    • Mandava, P.1    Suarez, J.I.2    Kent, T.A.3
  • 4
    • 65549170306 scopus 로고    scopus 로고
    • A method to determine stroke trial success using multidimensional pooled control functions
    • Mandava P, Kent TA. A method to determine stroke trial success using multidimensional pooled control functions. Stroke. 2009; 40: 1803-10.
    • (2009) Stroke , vol.40 , pp. 1803-1810
    • Mandava, P.1    Kent, T.A.2
  • 5
    • 10744220109 scopus 로고    scopus 로고
    • Outcome of urgent and elective percutaneous coronary interventions after pharmacologic reperfusion with tenecteplase combined with unfractionated heparin, enoxaparin, or abciximab
    • Dubois CL, Belmans A, Granger CB, Armstrong PW, Wallentin L, Fioretti PM, et al. Outcome of urgent and elective percutaneous coronary interventions after pharmacologic reperfusion with tenecteplase combined with unfractionated heparin, enoxaparin, or abciximab. J Am Coll Cardiol. 2003; 42: 1178-85.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1178-1185
    • Dubois, C.L.1    Belmans, A.2    Granger, C.B.3    Armstrong, P.W.4    Wallentin, L.5    Fioretti, P.M.6
  • 6
    • 32644482768 scopus 로고    scopus 로고
    • Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): Randomised trial
    • Assessment of the Safety and Efficacy of a New Treatment Strategy with Percuataneous Coronary Intervention (ASSENT-4 PCI) Investigators
    • Assessment of the Safety and Efficacy of a New Treatment Strategy with Percuataneous Coronary Intervention (ASSENT-4 PCI) Investigators. Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial. Lancet. 2006; 367: 569-78.
    • (2006) Lancet , vol.367 , pp. 569-578
  • 7
    • 38149053126 scopus 로고    scopus 로고
    • Emergency administration of Abciximab for treatment of patients with acute ischemic stroke: Results of an International Phase III Trial: Abciximab in emergency treatment of stroke trial (AbESTT-II)
    • Adams HP, Effron MB, Torner J, Davalos A, Frayne J, Teal P, et al. Emergency administration of Abciximab for treatment of patients with acute ischemic stroke: results of an International Phase III Trial: Abciximab in emergency treatment of stroke trial (AbESTT-II). Stroke. 2008; 39: 87-99.
    • (2008) Stroke , vol.39 , pp. 87-99
    • Adams, H.P.1    Effron, M.B.2    Torner, J.3    Davalos, A.4    Frayne, J.5    Teal, P.6
  • 8
    • 43749099194 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa antagonists in acute Ischaemic stroke. Current status and future directions
    • Mandava P, Thiagarajan P, Kent TA. Glycoprotein IIb/IIIa antagonists in acute Ischaemic stroke. Current status and future directions. Drugs. 2008; 68: 1019-28.
    • (2008) Drugs , vol.68 , pp. 1019-1028
    • Mandava, P.1    Thiagarajan, P.2    Kent, T.A.3
  • 9
    • 0032189318 scopus 로고    scopus 로고
    • Reduced microvascular Thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation
    • Choudhri TF, Hoh BL, Zerwes H-G, Prestigiacomo CJ, Kim SC, Connolly Jr ES, et al. Reduced microvascular Thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation. J Clin Invest. 1998; 102: 1301-10.
    • (1998) J Clin Invest , vol.102 , pp. 1301-1310
    • Choudhri, T.F.1    Hoh, B.L.2    Zerwes, H.-G.3    Prestigiacomo, C.J.4    Kim, S.C.5    Connolly Jr., E.S.6
  • 11
    • 11844295450 scopus 로고    scopus 로고
    • Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIB/IIIa inhibitor
    • Ding G, Jiang Q, Zhang L, Zhang ZG, Li L, Knight RA, et al. Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIB/IIIa inhibitor. JCBF. 2005; 25: 87-97.
    • (2005) Jcbf , vol.25 , pp. 87-97
    • Ding, G.1    Jiang, Q.2    Zhang, L.3    Zhang, Z.G.4    Li, L.5    Knight, R.A.6
  • 12
    • 0024848055 scopus 로고
    • Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor: Correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors
    • Coller BS, Folts JD, Smith SR, Scudder LE, Jordan R. Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor: correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors. Circulation. 1989; 80: 1766-74.
    • (1989) Circulation , vol.80 , pp. 1766-1774
    • Coller, B.S.1    Folts, J.D.2    Smith, S.R.3    Scudder, L.E.4    Jordan, R.5
  • 13
    • 34247643257 scopus 로고    scopus 로고
    • Targeting platelets in acute experimental stroke: Impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
    • Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, Stoll G. Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation. 2007; 115: 2323-30.
    • (2007) Circulation , vol.115 , pp. 2323-2330
    • Kleinschnitz, C.1    Pozgajova, M.2    Pham, M.3    Bendszus, M.4    Nieswandt, B.5    Stoll, G.6
  • 14
    • 0025744782 scopus 로고
    • A study of aspirin induced changes in bleeding time, platelet aggregation, and Sonoclot coagulation analysis in humans
    • Samra SK, Harrison RL, Bee DE, Valero V. A study of aspirin induced changes in bleeding time, platelet aggregation, and Sonoclot coagulation analysis in humans. Ann Clin Lab Sci. 1991; 21: 315-27.
    • (1991) Ann Clin Lab Sci , vol.21 , pp. 315-327
    • Samra, S.K.1    Harrison, R.L.2    Bee, D.E.3    Valero, V.4
  • 15
    • 16844383611 scopus 로고    scopus 로고
    • Emergency administration of abciximab for treatment of patients with acute ischemic stroke: Results of a randomized phase 2 trial
    • Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators
    • Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of a randomized phase 2 trial. Stroke. 2005; 36: 880-90.
    • (2005) Stroke , vol.36 , pp. 880-890
  • 16
    • 0031456834 scopus 로고    scopus 로고
    • Antiplatelet therapy: Do the new platelet inhibitors add significantly to the clinical benefit
    • Theroux P. Antiplatelet therapy: do the new platelet inhibitors add significantly to the clinical benefit. Am Heart J. 1997; 134: S62-70.
    • (1997) Am Heart J , vol.134
    • Theroux, P.1
  • 17
    • 2242477091 scopus 로고
    • Use of monoclonal antibody directed against the platelet glycoprotein iib/iiia receptor in high risk coronary angioplasty
    • The Epic Investigators
    • The Epic Investigators. Use of monoclonal antibody directed against the platelet glycoprotein iib/iiia receptor in high risk coronary angioplasty. N Eng J Med. 1994; 330: 956-61.
    • (1994) N Eng J Med , vol.330 , pp. 956-961
  • 18
    • 0030919511 scopus 로고    scopus 로고
    • Randomized placebo controlled trial of eptifibatide on complications of percutaneous coronary intervention:IMPACT-II. Integrilin to minimize platelet aggregation and coronary thrombosis-II
    • The Impact II investigators
    • The Impact II investigators. Randomized placebo controlled trial of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II. Integrilin to minimize platelet aggregation and coronary thrombosis-II. Lancet. 1997; 349: 1422-8.
    • (1997) Lancet , vol.349 , pp. 1422-1428
  • 19
    • 0030998690 scopus 로고    scopus 로고
    • Restoration of coronary flow in myocardial infarction by intravenous chimeric 7e3 antibody without exogenous plasminogen activators. Observations in animals and humans
    • Gold HK, Garabedian HD, Dinsmore RE, Guerrero LJ, Cigarroa JE, Palacios IF, et al. Restoration of coronary flow in myocardial infarction by intravenous chimeric 7e3 antibody without exogenous plasminogen activators. Observations in animals and humans. Circulation. 1997; 95: 1755-9.
    • (1997) Circulation , vol.95 , pp. 1755-1759
    • Gold, H.K.1    Garabedian, H.D.2    Dinsmore, R.E.3    Guerrero, L.J.4    Cigarroa, J.E.5    Palacios, I.F.6
  • 20
    • 77950292456 scopus 로고    scopus 로고
    • A matching algorithm to address imbalances in study populations. Application to the National Institute of Neurological Diseases and Stroke Recombinant Tissue Plasminogen Activator Acute Stroke Trial
    • Mandava P, Kalkonde YV, Rochat R, Kent TA. A matching algorithm to address imbalances in study populations. Application to the National Institute of Neurological Diseases and Stroke Recombinant Tissue Plasminogen Activator Acute Stroke Trial. Stroke. 2010; 41: 765-70.
    • (2010) Stroke , vol.41 , pp. 765-770
    • Mandava, P.1    Kalkonde, Y.V.2    Rochat, R.3    Kent, T.A.4
  • 21
    • 0033804936 scopus 로고    scopus 로고
    • Fatal hemorrhagic transformation of acute cerebral infarction after the use of abciximab
    • Cheung RT, Ho DS. Fatal hemorrhagic transformation of acute cerebral infarction after the use of abciximab. Stroke. 2000; 31: 2526-7.
    • (2000) Stroke , vol.31 , pp. 2526-2527
    • Cheung, R.T.1    Ho, D.S.2
  • 22
    • 0035849569 scopus 로고    scopus 로고
    • Rescue treatment with abciximab in acute ischemic stroke
    • Lee KY, Heo JH, Lee SI, Yoon PH. Rescue treatment with abciximab in acute ischemic stroke. Neurology. 2001; 56: 1585-7.
    • (2001) Neurology , vol.56 , pp. 1585-1587
    • Lee, K.Y.1    Heo, J.H.2    Lee, S.I.3    Yoon, P.H.4
  • 24
    • 27644541019 scopus 로고    scopus 로고
    • Reversal of dense signs predicts recovery in acute ischemic stroke
    • Mandava P, Kent TA. Reversal of dense signs predicts recovery in acute ischemic stroke. Stroke. 2005; 36: 2490-2.
    • (2005) Stroke , vol.36 , pp. 2490-2492
    • Mandava, P.1    Kent, T.A.2
  • 25
    • 0033539530 scopus 로고    scopus 로고
    • Attainment and maintenance of platelet inhibition through standard dosing of abciximab in diabetic and nondiabetic patients undergoing percutaneous coronary intervention
    • Steinhubl SR, Kottke-Marchant K, Moliterno DJ. Attainment and maintenance of platelet inhibition through standard dosing of abciximab in diabetic and nondiabetic patients undergoing percutaneous coronary intervention. Circulation. 1999; 100: 1977-82.
    • (1999) Circulation , vol.100 , pp. 1977-1982
    • Steinhubl, S.R.1    Kottke-Marchant, K.2    Moliterno, D.J.3
  • 26
    • 0035967496 scopus 로고    scopus 로고
    • Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention. Results of the GOLD (AU-Assessing Ultegra) Multicenter Study
    • Steinhubl SR, Talley D, Braden GA, Tcheng JE, Casterella PJ, Moliterno DJ, et al. Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention. Results of the GOLD (AU-Assessing Ultegra) Multicenter Study. Circulation. 2001; 103: 2572-8.
    • (2001) Circulation , vol.103 , pp. 2572-2578
    • Steinhubl, S.R.1    Talley, D.2    Braden, G.A.3    Tcheng, J.E.4    Casterella, P.J.5    Moliterno, D.J.6
  • 27
    • 0042739065 scopus 로고    scopus 로고
    • Assessing platelet function during treatment with glycoprotein IIb/IIIa antagonist
    • Steinhubl SR. Assessing platelet function during treatment with glycoprotein IIb/IIIa antagonist. Coron Artery Dis. 2003; 14: 381-6.
    • (2003) Coron Artery Dis , vol.14 , pp. 381-386
    • Steinhubl, S.R.1
  • 28
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group
    • The National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333: 1581-7.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 30
    • 77954954825 scopus 로고    scopus 로고
    • NIST/SEMATECH e-Handbook of Statistical Methods. Available at,Accessed 2 April 2010
    • NIST/SEMATECH e-Handbook of Statistical Methods. Available at www. itl. nist. gov/div898/handbook/ Chapters 1& 7. Accessed 2 April 2010.
  • 31
    • 44449108063 scopus 로고    scopus 로고
    • A user's guide to the NINDS rt-PA stroke trial database
    • Dachs RJ, Burton H, Joslin J. A user's guide to the NINDS rt-PA stroke trial database. PLoS Med. 2008; 5: e113.
    • (2008) PLoS Med , vol.5
    • Dachs, R.J.1    Burton, H.2    Joslin, J.3
  • 32
    • 0029050323 scopus 로고
    • Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS)
    • Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: the European Cooperative Acute Stroke Study (ECASS). JAMA. 1995; 274: 1017-25.
    • (1995) Jama , vol.274 , pp. 1017-1025
    • Hacke, W.1    Kaste, M.2    Fieschi, C.3    Toni, D.4    Lesaffre, E.5    von Kummer, R.6
  • 33
    • 0032541845 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II)
    • Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet. 1998; 352: 1245-51.
    • (1998) Lancet , vol.352 , pp. 1245-1251
    • Hacke, W.1    Kaste, M.2    Fieschi, C.3    von Kummer, R.4    Davalos, A.5    Meier, D.6
  • 35
    • 11144226333 scopus 로고    scopus 로고
    • Sex-based differences in responses to recombinant tissue plasminogen activator in acute ischemic stroke. A pooled analysis of randomized clinical trials
    • Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in responses to recombinant tissue plasminogen activator in acute ischemic stroke. A pooled analysis of randomized clinical trials. Stroke. 2005; 36: 62-5.
    • (2005) Stroke , vol.36 , pp. 62-65
    • Kent, D.M.1    Price, L.L.2    Ringleb, P.3    Hill, M.D.4    Selker, H.P.5
  • 36
    • 0035073903 scopus 로고    scopus 로고
    • Entry criteria and baseline characteristics predict outcome in acute stroke trials
    • Uchino K, Billheimer D, Cramer SC. Entry criteria and baseline characteristics predict outcome in acute stroke trials. Stroke. 2001; 32: 909-16.
    • (2001) Stroke , vol.32 , pp. 909-916
    • Uchino, K.1    Billheimer, D.2    Cramer, S.C.3
  • 37
    • 0347986835 scopus 로고    scopus 로고
    • Age and National Institutes of Health Stroke Scale Score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia: Development and external validation of prognostic models
    • German Stroke Study Collaboration
    • Weimar C, König IR, Kraywinkel K, Ziegler A, Diener HC, German Stroke Study Collaboration. Age and National Institutes of Health Stroke Scale Score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia: development and external validation of prognostic models. Stroke. 2004; 35: 158-62.
    • (2004) Stroke , vol.35 , pp. 158-162
    • Weimar, C.1    König, I.R.2    Kraywinkel, K.3    Ziegler, A.4    Diener, H.C.5
  • 38
    • 3242657072 scopus 로고    scopus 로고
    • How important is hyperglycemia during acute brain infarction?
    • Bruno A, Williams LS, Kent TA. How important is hyperglycemia during acute brain infarction? Neurologist. 2004; 10: 195-200.
    • (2004) Neurologist , vol.10 , pp. 195-200
    • Bruno, A.1    Williams, L.S.2    Kent, T.A.3
  • 39
    • 77954956258 scopus 로고    scopus 로고
    • Matlab. The language of technical computing. The Mathworks Inc. Boston, MA. Pp11. 18-11. 37.
  • 40
    • 70549105891 scopus 로고    scopus 로고
    • Bleeding in patients undergoing percutaneous coronary intervention: The development of a clinical risk algorithm from the National Cardiovascular Data Registry
    • Mehta SK, Frutkin AD, Lindsey JB, House JA, Spertus JA, Rao SV, et al. Bleeding in patients undergoing percutaneous coronary intervention: the development of a clinical risk algorithm from the National Cardiovascular Data Registry. Circ Cardiovasc Intervent. 2009; 2: 222-9.
    • (2009) Circ Cardiovasc Intervent , vol.2 , pp. 222-229
    • Mehta, S.K.1    Frutkin, A.D.2    Lindsey, J.B.3    House, J.A.4    Spertus, J.A.5    Rao, S.V.6
  • 41
    • 34249813700 scopus 로고    scopus 로고
    • Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits
    • Wong PC, Crain EJ, Watson CA, Jiang X, Hua J, Bostwick JS, et al. Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits. J Cardiovasc Pharmacol. 2007; 49: 316-24.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 316-324
    • Wong, P.C.1    Crain, E.J.2    Watson, C.A.3    Jiang, X.4    Hua, J.5    Bostwick, J.S.6
  • 43
    • 34249803295 scopus 로고    scopus 로고
    • Infrared laser therapy for ischemic stroke: A new treatment strategy: Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)
    • Lampl Y, Jivin JA, Fisher M, Lew R, Welin L, Dahlof B, et al. Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke. 2007; 38: 1843-9.
    • (2007) Stroke , vol.38 , pp. 1843-1849
    • Lampl, Y.1    Jivin, J.A.2    Fisher, M.3    Lew, R.4    Welin, L.5    Dahlof, B.6
  • 44
    • 58149358843 scopus 로고    scopus 로고
    • The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke. The CLEAR Stroke Trial
    • Pancioli AM, Broderick J, Brott T, Tomsick T, Khoury J, Bean J, et al. The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke. The CLEAR Stroke Trial. Stroke. 2008; 39: 3268-76.
    • (2008) Stroke , vol.39 , pp. 3268-3276
    • Pancioli, A.M.1    Broderick, J.2    Brott, T.3    Tomsick, T.4    Khoury, J.5    Bean, J.6
  • 45
    • 0033486107 scopus 로고    scopus 로고
    • Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    • Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999; 282: 2003-11.
    • (1999) Jama , vol.282 , pp. 2003-2011
    • Furlan, A.1    Higashida, R.2    Wechsler, L.3    Gent, M.4    Rowley, H.5    Kase, C.6
  • 46
  • 47
    • 0036589314 scopus 로고    scopus 로고
    • National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group. The NINDS Stroke Study Group response
    • Grotta JC. National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group. The NINDS Stroke Study Group response. J Stroke Cerebrovasc Dis. 2002; 11: 121-4.
    • (2002) J Stroke Cerebrovasc Dis , vol.11 , pp. 121-124
    • Grotta, J.C.1
  • 48
    • 4944222683 scopus 로고    scopus 로고
    • Findings from the reanalysis of the NINDS Tissue Plasminogen Activator for Acute Ischemic Stroke Treatment Trial
    • Ingall TJ, O'Fallon WM, Asplund K, Goldfrank LR, Hertzberg VS, Louis TA, et al. Findings from the reanalysis of the NINDS Tissue Plasminogen Activator for Acute Ischemic Stroke Treatment Trial. Stroke. 2004; 35: 2418-24.
    • (2004) Stroke , vol.35 , pp. 2418-2424
    • Ingall, T.J.1    O'Fallon, W.M.2    Asplund, K.3    Goldfrank, L.R.4    Hertzberg, V.S.5    Louis, T.A.6
  • 49
    • 23244459237 scopus 로고    scopus 로고
    • Acute hyperglycemia state is associated with lower tPA-induced recanalization rates in stroke patients
    • Ribo M, Molina C, Montaner J, Rubiera M, Delgado-Mederos R, Arenillas JF, et al. Acute hyperglycemia state is associated with lower tPA-induced recanalization rates in stroke patients. Stroke. 2005; 36: 1705-9.
    • (2005) Stroke , vol.36 , pp. 1705-1709
    • Ribo, M.1    Molina, C.2    Montaner, J.3    Rubiera, M.4    Delgado-Mederos, R.5    Arenillas, J.F.6
  • 50
    • 33847215407 scopus 로고    scopus 로고
    • Hyperglycemia in acute ischemic stroke: A vascular perspective
    • Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. JCBF. 2007; 27: 435-51.
    • (2007) Jcbf , vol.27 , pp. 435-451
    • Martini, S.R.1    Kent, T.A.2
  • 51
    • 0342514814 scopus 로고    scopus 로고
    • Abciximab in acute ischemic stroke. A randomized, double-blind, placebo-controlled, dose-escalation study
    • The Abciximab in Ischemic Stroke Investigators
    • The Abciximab in Ischemic Stroke Investigators. Abciximab in acute ischemic stroke. A randomized, double-blind, placebo-controlled, dose-escalation study. Stroke. 2000; 31: 601-9.
    • (2000) Stroke , vol.31 , pp. 601-609
  • 54
    • 74249089698 scopus 로고    scopus 로고
    • Effect of intravenous tirofiban and aspirin in reducing short-term and long-term neurologic deficit in patients with ischemic stroke: A double-blind randomized trial
    • Torgano G, Zecca B, Monzani V, Maestroni A, Rossi P, Cazzaniga M, et al. Effect of intravenous tirofiban and aspirin in reducing short-term and long-term neurologic deficit in patients with ischemic stroke: a double-blind randomized trial. Cerebrovasc Dis. 2010; 29: 275-81.
    • (2010) Cerebrovasc Dis , vol.29 , pp. 275-281
    • Torgano, G.1    Zecca, B.2    Monzani, V.3    Maestroni, A.4    Rossi, P.5    Cazzaniga, M.6
  • 55
    • 54049152026 scopus 로고    scopus 로고
    • The GPIIb/IIIa (integrin αIIbβ3) odyssey: A technology-driven saga of a receptor with twists, turns, and even a bend
    • Coller BS, Shattil SJ. The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 2008; 112: 3011-25.
    • (2008) Blood , vol.112 , pp. 3011-3025
    • Coller, B.S.1    Shattil, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.