Cortisol production rate is similarly elevated in obese women with or without the polycystic ovary syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 7, 2010, Pages 3318-3324

  Roelfsema, Ferdinand ^a   Kok, Petra ^a   Pereira, Alberto M ^a   Pijl, Hanno ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; ESTRADIOL; PROGESTERONE; PROLACTIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGE DISTRIBUTION; ARTICLE; BLOOD SAMPLING; BODY MASS; BODY SURFACE; BODY WEIGHT; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONTROLLED STUDY; ENTROPY; FEMALE; HORMONE SYNTHESIS; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; LEAN BODY WEIGHT; MENSTRUAL CYCLE; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; RISK FACTOR; SENSITIVITY ANALYSIS; ANALYSIS OF VARIANCE; BIOSYNTHESIS; BLOOD; BODY COMPOSITION; METABOLISM; PHYSIOLOGY; RADIOIMMUNOASSAY;

ANALYSIS OF VARIANCE; BODY COMPOSITION; BODY MASS INDEX; CIRCADIAN RHYTHM; ESTRADIOL; FEMALE; HUMANS; HYDROCORTISONE; OBESITY; POLYCYSTIC OVARY SYNDROME; PROGESTERONE; PROLACTIN; RADIOIMMUNOASSAY; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 77954942976     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2701     Document Type: Article

References (38)

1. Marshall JC, Eagleson CA 1999 Neuroendocrine aspects of polycystic ovary syndrome. Endocrinol Metab Clin North Am 28:295-324
2. Rodin A, Thakkar H, Taylor N, Clayton R 1994 Hyperandrogenism in polycystic ovary syndrome:evidence of dysregulation of 11β-hydroxysteroid dehydrogenase. N Engl J Med 330:460-465
3. Vassiliadi DA, Barber TM, Hughes BA, McCarthy MI, Wass JA, Franks S, Nightingale P, Tomlinson JW, Arlt W, Stewart PM 2009 Increased 5α-reductase activity and adrenal cortical drive in women with polycystic ovary syndrome. J Clin Endocrinol Metab 94:3558-3566
4. Lanzone A, Fulghesu AM, Guido M, Cucinelli F, Caruso A, Mancuso S 1997 Somatostatin treatment reduces the exaggerated response of adrenocorticotropin hormone and cortisol to corticotropin-releasing hormone in polycystic ovary syndrome. Fertil Steril 67:34-39
5. Gennarelli G, Holte J, Stridsberg M, Lundqvist U, Massobrio M, Bäckström T, Berne C 1999 Response of the pituitary-adrenal axis to hypoglycemic stress in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 84:76-81
6. Invitti C, De Martin M, Delitala G, Veldhuis JD, Cavagnini F 1998 Altered morning and nighttime pulsatile corticotropin and cortisol release in polycystic ovary syndrome. Metabolism 47:143-148
7. Glintborg D, Hermann AP, Brusgaard K, Hangaard J, Hagen C, Andersen M 2005 Significantly higher adrenocorticotropin-stimulated cortisol and 17-hydroxyprogesterone levels in 337 consecutive, premenopausal, Caucasian, hirsute patients compared with healthy controls. J Clin Endocrinol Metab 90:1347-1353
8. Azziz R, Black V, Hines GA, Fox LM, Boots LR 1998 Adrenal androgen excess in the polycystic ovary syndrome: sensitivity and responsivity of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab 83:2317-2323
9. Veldhuis JD, Roelfsema F, Iranmanesh A, Carroll BJ, Keenan DM, Pincus SM 2009 Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index. J Clin Endocrinol Metab 94:4045-4052
10. Dunkelman SS, Fairhurst B, Plager J, Waterhouse C 1964 Cortisol metabolism in obesity. J Clin Endocrinol Metab 24:832-841
11. Strain GW, Zumoff B, Strain JJ, Levin J, Fukushima DK 1980 Cortisol production in obesity. Metabolism 29:980-985
12. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH 1999 Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84:1022-1027
13. Andrew R, Phillips DI, Walker BR 1998 Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 83:1806-1809
14. Purnell JQ, Kahn SE, Samuels MH, Brandon D, Loriaux DL, Brunzell JD 2009 Enhanced cortisol production rates, free cortisol, and 11β-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss. Am J Physiol Endocrinol Metab 296:E351-E357
15. Roelfsema F, Kok P, Frolich M, Pereira AM, Pijl H 2009 Disordered and increased adrenocorticotropin secretion with diminished adrenocorticotropin potency in obese premenopausal women. J Clin Endocrinol Metab 94:2991-2997
16. Keenan DM, Roelfsema F, Biermasz N, Veldhuis JD 2003 Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis. Am J Physiol Regul Integr Comp Physiol 285:R664-R673
17. Pincus SM 2000 Irregularity and asynchrony in biologic network signals. Methods Enzymol 321:149-182
18. Keenan DM, Veldhuis JD 2001 Hypothesis testing of the aging male gonadal axis via a biomathematical construct. Am J Physiol Regul Integr Comp Physiol 280:R1755-R1771
19. Kraan GP, Dullaart RP, Pratt JJ, Wolthers BG, Drayer NM, De Bruin R 1998 The daily cortisol production reinvestigated in healthy men. The serum and urinary cortisol production rates are not significantly different, J Clin Endocrinol Metab 83:1247-1252
20. Bright GM 1995 Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance. J Clin Endocrinol Metab 80:770-775
21. Samuels MH, Brandon DD, Isabelle LM, Cook DM, Graham KE, Purnell JQ, Loriaux DL 2000 Cortisol production rates in subjects with suspected Cushing's syndrome: Assessment by stable isotope dilution methodology and comparison to other diagnostic methods. J Clin Endocrinol Metab 85:22-28
22. Esteban NV, Yergey AL 1990 Cortisol production rates measured by liquid chromatography/mass spectrometry. Steroids 55:152-158
23. Veldhuis JD, Keenan DM, Pincus SM 2008 Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 29:823-864
24. Preleviæ GM,Würzburger MI, Balint-Periæ L 1993 24-Hour serum cortisol profiles in women with polycystic ovary syndrome. Gynecol Endocrinol 7:179-184
25. Walker BR, Rodin A, Taylor NF, Clayton RN 2000 Endogenous inhibitors of 11β-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome. Clin Endocrinol (Oxf) 52:77-80
26. Svendsen PF, Madsbad S, Nilas L, Paulsen SK, Pedersen SB 2009 Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in subcutaneous adipose tissue of lean and obese women with and without polycystic ovary syndrome. Int J Obes (Lond) 33:1249-1256
27. Fassnacht M, Schlenz N, Schneider SB, Wudy SA, Allolio B, Arlt W 2003 Beyond adrenal and ovarian androgen generation: increased peripheral 5a-reductase activity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88:2760-2766
28. Kok P, Kok SW, Buijs MM, Westenberg JJ, Roelfsema F, Frölich M, Stokkel MP, Meinders AE, Pijl H 2004 Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment. Am J Physiol Endocrinol Metab 287:E848-E856
29. Tomlinson JW, Finney J, Hughes BA, Hughes SV, Stewart PM 2008 Reduced glucocorticoid production rate, decreased 5α-reductase activity, and adipose tissue insulin sensitization after weight loss. Diabetes 57:1536-1543
30. Benson S, Arck PC, Tan S, Hahn S, Mann K, Rifaie N, Janssen OE, Schedlowski M, Elsenbruch S 2009 Disturbed stress responses in women with polycystic ovary syndrome. Psychoneuroendocrinology 34:727-735
31. Morimoto I, Yamamoto S, Kai K, Fujihira T, Morita E, Eto S 2000 Centrally administered murin-leptin stimulates the hypothalamuspituitary- adrenal axis through arginine-vasopressin. Neuroendocrinology 71:366-374
32. Malcher-Lopes R, Di S, Marcheselli VS, Weng FJ, Stuart CT, Bazan NG, Tasker JG 2006 Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 26:6643-6650
33. Stewart PM, Shackleton CH, Beastall GH, Edwards CR 1990 5α-reductase activity in polycystic ovary syndrome. Lancet 335:431-433
34. Glintborg D, Hermann AP, Hagen C, Jensen LT, Frystyk J, Bennett P, Flyvbjerg A, Andersen M 2009 A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome. Fertil Steril 91:842-850
35. Stewart PM, Penn R, Holder R, Ratcliffe JG, London DR 1993 The hypothalamo-pituitary-adrenal axis across the normal menstrual cycle and in polycystic ovary syndrome. Clin Endocrinol (Oxf) 38: 387-391
36. Van Dam EW, Roelfsema F, Helmerhorst FH, Frölich M, Meinders AE, Veldhuis JD, Pijl H 2002 Low amplitude and disorderly spontaneous growth hormone release in obese women with or without polycystic ovary syndrome. J Clin Endocrinol Metab 87:4225-4230
37. Keenan DM, Roelfsema F, Carroll BJ, Iranmanesh A, Veldhuis JD 2009 Sex defines the age dependency of endogenous ACTH-cortisol dose responsiveness. Am J Physiol Regul Integr Comp Physiol 297: R515-R523
38. Darj E, Axelsson O, Carlström K, Nilsson S, von Schoultz B 1993 Liver metabolism during treatment with estradiol and natural progesterone. Gynecol Endocrinol 7:111-114