Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell cultures 1

Biochemistry and Cell Biology

Volumn 88, Issue 4, 2010, Pages 611-620

  Niu, Jianqin ^a   Mei, Feng ^a   Li, Nan ^a   Wang, Hanzhi ^a   Li, Xinmin ^b   Kong, Jiming ^b   Xiao, Lan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Dopamine receptor; Haloperidol; Oligodendrocyte progenitor cell; Proliferation; Schizophrenia

Indexed keywords

ANTIPSYCHOTIC DRUG; BRAIN REGIONS; CELLULAR MECHANISMS; COGNITIVE DEFICITS; DOWN-REGULATION; MYELIN BASIC PROTEIN; OLIGODENDROCYTES; PROGENITOR CELL; SIDE EFFECT; TERMINAL DIFFERENTIATION; THERAPEUTIC EFFECTS;

BRAIN; CELLS; DRUG INTERACTIONS; FUZZY CONTROL;

CELL CULTURE;

DOPAMINE 3 RECEPTOR; HALOPERIDOL; MESSENGER RNA; MYELIN BASIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN REGULATION; DRUG MECHANISM; IMMUNOCYTOCHEMISTRY; NONHUMAN; OLIGODENDROGLIA; RAT; STEM CELL;

ANIMALS; ANTIPSYCHOTIC AGENTS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HALOPERIDOL; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D3; STEM CELLS;

RATTUS;

EID: 77954927653     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/O09-178     Document Type: Article

References (36)

1. Bongarzone, E.R., Howard, S.G., Schonmann, V., and Campagnoni, A.T. 1998. Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation. J. Neurosci. 18(14): 5344-5353. PMID:9651217.
2. Chakos, M.H., Alvir, J.M., Woerner, M.G., Koreen, A., Geisler, S., Mayerhoff, D., et al. 1996. Incidence and correlates of tardive dyskinesia in first episode of schizophrenia. Arch. Gen. Psychiatry, 53(4): 313-319. PMID:8634009.
3. Chen, Y., Balasubramaniyan, V., Peng, J., Hurlock, E.C., Tallquist, M., Li, J., and Lu, Q.R. 2007. Isolation and culture of rat and mouse oligodendrocyte precursor cells. Nat. Protoc. 2(5): 1044-1051. doi:10.1038/nprot.2007.149. PMID:17546009.
4. Creese, I., Burt, D.R., and Snyder, S.H. 1976. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science, 192(4238): 481-483. doi:10.1126/ science.3854. PMID:3854.
5. Davis, K.L., Stewart, D.G., Friedman, J.I., Buchsbaum, M., Harvey, P.D., Hof, P.R., et al. 2003. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch. Gen. Psychiatry, 60(5): 443-456. doi:10.1001/archpsyc.60.5.443. PMID:12742865.
6. Dawirs, R.R., Hildebrandt, K., and Teuchert-Noodt, G. 1998. Adult treatment with haloperidol increases dentate granule cell proliferation in the gerbil hippocampus. J. Neural Transm. 105(2-3): 317-327.doi:10.1007/s007020050061. PMID:9660110.
7. Flynn, S.W., Lang, D.J., Mackay, A.L., Goghari, V., Vavasour, I.M., Whittall, K.P., et al. 2003. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Mol. Psychiatry, 8(9): 811-820. doi:10.1038/sj.mp.4001337. PMID:12931208.
8. Foong, J., Maier, M., Barker, G.J., Brocklehurst, S., Miller, D.H., and Ron, M.A. 2000. In vivo investigation of white matter pathology in schizophrenia with magnetisation transfer imaging. J. Neurol. Neurosurg. Psychiatry, 68(1): 70-74. doi:10.1136/jnnp.68.1.70. PMID:10601405.
9. Fressinaud, C., Laeng, P., Labourdette, G., Durand, J., and Vallat, J.M. 1993. The proliferation of mature oligodendrocytes in vitro is stimulated by basic fibroblast growth factor and inhibited by oligodendrocyte-type 2 astrocyte precursors. Dev. Biol. 158(2): 317-329. doi:10.1006/dbio.1993.1191. PMID:8344453.
10. Gard, A.L., and Pfeiffer, S.E. 1989. Oligodendrocyte progenitors isolated directly from developing telencephalon at a specific phenotypic stage: myelinogenic potential in a defined environment. Development, 106(1): 119-132. PMID:2697546.
11. Glick, I.D., and Marder, S.R. 2005. Long-term maintenance therapy with quetiapine versus haloperidol decanoate in patients with schizophrenia or schizoaffective disorder. J. Clin. Psychiatry, 66(5): 638-641. doi:10.4088/JCP.v66n0515. PMID:15889952.
12. Gobert, R.P., Joubert, L., Curchod, M.L., Salvat, C., Foucault, I., Jorand-Lebrun, C., et al. 2009. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29(6): 1538-1553. doi:10.1128/MCB.01375-08. PMID:19139271.
13. Halim, N.D., Weickert, C.S., McClintock, B.W., Weinberger, D.R., and Lipska, B.K. 2004. Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus. Neuropsychopharmacology, 29(6): 1063-1069. doi:10.1038/sj. npp.1300422. PMID:15010699.
14. Harrison, P.J., and Weinberger, D.R. 2005. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry, 10(1): 40-68, 5. doi:10.1038/sj.mp. 4001558. PMID:15263907.
15. Hof, P.R., Haroutunian, V., Friedrich, V.L., Jr., Byne, W., Buitron, C., Perl, D.P., and Davis, K.L. 2003. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol. Psychiatry, 53(12): 1075-1085. doi:10. 1016/S0006-3223(03)00237-3. PMID:12814859.
16. Howard, S., Landry, C., Fisher, R., Bezouglaia, O., Handley, V., and Campagnoni, A. 1998. Postnatal localization and morphogenesis of cells expressing the dopaminergic D2 receptor gene in rat brain: expression in non-neuronal cells. J. Comp. Neurol. 391(1): 87-98. doi:10.1002/(SICI)1096-9861(19980202) 391:1<87::AID-CNE8>3.0.CO;2-N. PMID:9527544.
17. Karoutzou, G., Emrich, H.M., and Dietrich, D.E. 2008. The myelin-pathogenesis puzzle in schizophrenia: a literature review. Mol. Psychiatry, 13(3): 245-260. doi:10.1038/sj.mp.4002096. PMID:17925796.
18. Konopaske, G.T., Dorph-Petersen, K.A., Sweet, R.A., Pierri, J.N., Zhang, W., Sampson, A.R., and Lewis, D.A. 2008. Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol. Psychiatry, 63(8): 759-765. doi:10.1016/j.biopsych.2007.08.018. PMID:17945195.
19. Lu, Q.R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C.D., and Rowitch, D.H. 2002. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell, 109(1): 75-86. doi:10.1016/S0092-8674(02)00678-5. PMID:11955448.
20. Malberg, J.E., Eisch, A.J., Nestler, E.J., and Duman, R.S. 2000. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20(24): 9104-9110. PMID: 11124987.
21. Narayan, S., Kass, K.E., and Thomas, E.A. 2007. Chronic haloperidol treatment results in a decrease in the expression of myelin/ oligodendrocyte-related genes in the mouse brain. J. Neurosci. Res. 85(4): 757-765. doi:10.1002/jnr.21161. PMID:17177202.
22. Noh, J.S., Kang, H.J., Kim, E.Y., Sohn, S., Chung, Y.K., Kim, S.U., and Gwag, B.J. 2000. Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase. J. Neurochem. 75(6): 2327-2334. doi:10.1046/j.1471-4159.2000. 0752327.x. PMID:11080184.
23. Pfeiffer, S.E., Warrington, A.E., and Bansal, R. 1993. The oligodendrocyte and its many cellular processes. Trends Cell Biol. 3(6): 191-197. doi:10.1016/0962-8924(93)90213-K. PMID: 14731493.
24. Preskorn, S.H. 2005. Clinical application of the concept of relative potency: an example involving chlorpromazine and haloperidol. J. Psychiatr. Pract. 11(4): 258-261. doi:10.1097/00131746-200507000-00006. PMID:16041236.
25. Reynolds, R., and Wilkin, G.P. 1988. Development of macroglial cells in rat cerebellum. II. An in situ immunohistochemical study of oligodendroglial lineage from precursor to mature myelinating cell. Development, 102(2): 409-425. PMID:2458224.
26. Rosin, C., Colombo, S., Calver, A.A., Bates, T.E., and Skaper, S.D. 2005. Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52(4): 336-343. doi:10.1002/glia.20250. PMID:16078234.
27. Schmitt, A., Weber, S., Jatzko, A., Braus, D.F., and Henn, F.A. 2004. Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment. J. Neural Transm. 111(1): 91-100. doi:10.1007/s00702-003-0070-2. PMID:14714218.
28. Sigmundsson, T., Suckling, J., Maier, M., Williams, S., Bullmore, E., Greenwood, K., et al. 2001. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am. J. Psychiatry, 158(2): 234-243. doi:10.1176/appi.ajp.158.2.234. PMID:11156806.
29. Stangel, M., and Hartung, H.P. 2002. Remyelinating strategies for the treatment of multiple sclerosis. Prog. Neurobiol. 68(5): 361-376. doi:10.1016/S0301-0082(02)00105-3. PMID:12531235.
30. Sugai, T., Kawamura, M., Iritani, S., Araki, K., Makifuchi, T., Imai, C., et al. 2004. Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression. Ann. N. Y. Acad. Sci. 1025(1): 84-91. doi:10. 1196/annals.1316.011. PMID:15542704.
31. Tandon, R., and Jibson, M.D. 2003. Efficacy of newer generation antipsychotics in the treatment of schizophrenia. Psychoneuroen docrinology, 28(Suppl 1): 9-26. doi:10.1016/S0306-4530(02) 00110-5. PMID:12504069.
32. Wakade, C.G., Mahadik, S.P., Waller, J.L., and Chiu, F.C. 2002. Atypical neuroleptics stimulate neurogenesis in adult rat brain. J. Neurosci. Res. 69(1): 72-79. doi:10.1002/jnr.10281. PMID: 12111817.
33. Wang, H.D., Dunnavant, F.D., Jarman, T., and Deutch, A.Y. 2004. Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat. Neuropsychopharmacology, 29(7): 1230-1238. doi:10.1038/sj.npp.1300449. PMID:15085089.
34. Wang, H., Xu, H., Dyck, L.E., and Li, X.M. 2005. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)induced oxidative stress and the ensuing apoptosis. J. Neurosci. Res. 81(4): 572-580. doi:10.1002/jnr.20570. PMID:15948179.
35. Xiao, L., Xu, H., Zhang, Y., Wei, Z., He, J., Jiang, W., et al. 2008. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol. Psychiatry, 13(7): 697-708. doi:10.1038/sj.mp.4002064. PMID: 17684494.
36. Yan, B., Bi, X., He, J., Zhang, Y., Thakur, S., Xu, H., et al. 2007. Quetiapine attenuates spatial memory impairment and hippocampal neurodegeneration induced by bilateral common carotid artery occlusion in mice. Life Sci. 81(5): 353-361. doi:10.1016/ j.lfs.2007.05.020. PMID:17631910.