Targeted DNA methylation by a DNA methyltransferase coupled to a triple helix forming oligonucleotide to down-regulate the epithelial cell adhesion molecule

Bioconjugate Chemistry

Volumn 21, Issue 7, 2010, Pages 1239-1245

  Van Der Gun, Bernardina T F ^a   Maluszynska Hoffman, Maria ^b   Kiss, Antal ^c   Arendzen, Alice J ^a   Ruiters, Marcel H J ^d   McLaughlin, Pamela M J ^a   Weinhold, Elmar ^b   Rots, Marianne G ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d Synvolux Therapeutics Inc   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CELL ADHESION; DNA; GENE ENCODING; METHYLATION;

DNA METHYLATION; DNA-METHYLTRANSFERASE; DOWN-STREAM; EPITHELIAL CELL ADHESION MOLECULES; GREEN FLUORESCENT PROTEIN; ONCOGENIC POTENTIAL; PLASMID ENCODING; PROMOTER ACTIVITIES; PROMOTER FRAGMENTS; TRIPLE HELIXES;

OLIGONUCLEOTIDES;

CPG OLIGODEOXYNUCLEOTIDE; DNA METHYLTRANSFERASE; EPITHELIAL CELL ADHESION MOLECULE; GREEN FLUORESCENT PROTEIN; PLASMID DNA;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; DRUG CONJUGATION; DRUG DESIGN; DRUG SPECIFICITY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; PROMOTER REGION; TRIPLE HELIX;

EID: 77954879338     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc1000388     Document Type: Article

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