메뉴 건너뛰기




Volumn 20, Issue 5, 2008, Pages 1061-1067

CpG island methylation status in the EpCAM promoter region and gene expression

Author keywords

5 Aza 2 deoxytidine; Bisulfate sequencing PCR; CpG island; Epithelial cell adhesion molecule; Methylation; Promoter

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE; CELL ADHESION MOLECULE; TACSTD1 PROTEIN, HUMAN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 58149359348     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000110     Document Type: Article
Times cited : (19)

References (35)
  • 1
    • 0027465045 scopus 로고
    • Retroposition in a family of carcinoma-associated antigen genes
    • Linnenbach AJ, Seng BA, Wu S, et al: Retroposition in a family of carcinoma-associated antigen genes. Mol Cell Biol 13: 1507-1515, 1993.
    • (1993) Mol Cell Biol , vol.13 , pp. 1507-1515
    • Linnenbach, A.J.1    Seng, B.A.2    Wu, S.3
  • 5
    • 0025341538 scopus 로고
    • Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2
    • Szala S, Froehlich M, Scollon M, et al: Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. Proc Natl Acad Sci USA 87: 3542-3546, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3542-3546
    • Szala, S.1    Froehlich, M.2    Scollon, M.3
  • 6
    • 0025346920 scopus 로고
    • Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein
    • Simon B, Podolsky DK, Moldenhauer G, Isseibacher KJ, Gattoni-Celli S and Brand SJ: Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein. Proc Natl Acad Sci USA 87: 2755-2759, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2755-2759
    • Simon, B.1    Podolsky, D.K.2    Moldenhauer, G.3    Isseibacher, K.J.4    Gattoni-Celli, S.5    Brand, S.J.6
  • 7
    • 0024496677 scopus 로고
    • Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA
    • Strnad J, Hamilton AE, Beavers LS, et al: Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA. Cancer Res 49: 314-317, 1989.
    • (1989) Cancer Res , vol.49 , pp. 314-317
    • Strnad, J.1    Hamilton, A.E.2    Beavers, L.S.3
  • 8
    • 0035045052 scopus 로고    scopus 로고
    • Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization
    • Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E and Alberti S: Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. Cytogenet Cell Genet 92: 164-165, 2001.
    • (2001) Cytogenet Cell Genet , vol.92 , pp. 164-165
    • Calabrese, G.1    Crescenzi, C.2    Morizio, E.3    Palka, G.4    Guerra, E.5    Alberti, S.6
  • 9
    • 0027460426 scopus 로고
    • Effect of monoclonal antibody 17-1A and GM-CSF in patients with advanced colorectal carcinoma - long-lasting, complete remissions can be induced
    • Ragnhammar P, Fagerberg J, Frodin JE, et al: Effect of monoclonal antibody 17-1A and GM-CSF in patients with advanced colorectal carcinoma - long-lasting, complete remissions can be induced. Int J Cancer 53: 751-758, 1993.
    • (1993) Int J Cancer , vol.53 , pp. 751-758
    • Ragnhammar, P.1    Fagerberg, J.2    Frodin, J.E.3
  • 10
    • 0343965762 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for resected Dukes' C colorectal cancer: Seven-year outcome of a multicenter randomized trial
    • Riethmuller G, Holz E, Schlimok G, et al: Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial. J Clin Oncol 16: 1788-1794, 1998.
    • (1998) J Clin Oncol , vol.16 , pp. 1788-1794
    • Riethmuller, G.1    Holz, E.2    Schlimok, G.3
  • 11
    • 1642580506 scopus 로고    scopus 로고
    • Frequent EpCam protein expression in human carcinomas
    • Went PT, Lugli A, Meier S, et al: Frequent EpCam protein expression in human carcinomas. Hum Pathol 35: 122-128, 2004.
    • (2004) Hum Pathol , vol.35 , pp. 122-128
    • Went, P.T.1    Lugli, A.2    Meier, S.3
  • 12
    • 0037140119 scopus 로고    scopus 로고
    • Prognostic significance of Ep-CAM AND Her-2/neu overexpression in invasive breast cancer
    • Spizzo G, Obrist P, Ensinger C, et al: Prognostic significance of Ep-CAM AND Her-2/neu overexpression in invasive breast cancer. Int J Cancer 98: 883-888, 2002.
    • (2002) Int J Cancer , vol.98 , pp. 883-888
    • Spizzo, G.1    Obrist, P.2    Ensinger, C.3
  • 13
    • 11144358272 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (KSA) expression: Pathobiology and its role as an independent predictor of survival in renal cell carcinoma
    • Seligson DB, Pantuck AJ, Liu X, et al: Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an independent predictor of survival in renal cell carcinoma. Clin Cancer Res 10: 2659-2669, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 2659-2669
    • Seligson, D.B.1    Pantuck, A.J.2    Liu, X.3
  • 14
    • 2442474077 scopus 로고    scopus 로고
    • Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival
    • Varga M, Obrist P, Schneeberger S, et al: Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res 10: 3131-3136, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 3131-3136
    • Varga, M.1    Obrist, P.2    Schneeberger, S.3
  • 15
    • 0042029375 scopus 로고    scopus 로고
    • Cloning and characterisation of a 1.1 kb fragment of the carcinomaassociated epithelial cell adhesion molecule promoter
    • Gires O, Eskofier S, Lang S, Zeidler R and Munz M: Cloning and characterisation of a 1.1 kb fragment of the carcinomaassociated epithelial cell adhesion molecule promoter. Anticancer Res 23: 3255-3261, 2003.
    • (2003) Anticancer Res , vol.23 , pp. 3255-3261
    • Gires, O.1    Eskofier, S.2    Lang, S.3    Zeidler, R.4    Munz, M.5
  • 16
    • 4444274009 scopus 로고    scopus 로고
    • Use of the EGP-2/ Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines
    • McLaughlin PM, Trzpis M, Kroesen BJ, et al: Use of the EGP-2/ Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines. Cancer Gene Ther 11: 603-612, 2004.
    • (2004) Cancer Gene Ther , vol.11 , pp. 603-612
    • McLaughlin, P.M.1    Trzpis, M.2    Kroesen, B.J.3
  • 17
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428, 2002.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 18
    • 0035962631 scopus 로고    scopus 로고
    • DNA methylation, methyltransferases, and cancer
    • Robertson KD: DNA methylation, methyltransferases, and cancer. Oncogene 20: 3139-3155, 2001.
    • (2001) Oncogene , vol.20 , pp. 3139-3155
    • Robertson, K.D.1
  • 19
    • 0027239823 scopus 로고
    • bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada M, Delia D, Aiello A, Stadtmauer E and Reed JC: bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 82: 1820-1828, 1993.
    • (1993) Blood , vol.82 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3    Stadtmauer, E.4    Reed, J.C.5
  • 20
    • 0029957792 scopus 로고    scopus 로고
    • The activation of human gene MAGE-1 in tumor cells is correlated with genomewide demethylation
    • De Smet C, De Backer O, Faraoni I, et al: The activation of human gene MAGE-1 in tumor cells is correlated with genomewide demethylation. Proc Natl Acad Sci USA 93: 7149-7153, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7149-7153
    • De Smet, C.1    De Backer, O.2    Faraoni, I.3
  • 21
    • 0032403478 scopus 로고    scopus 로고
    • Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias
    • Nakayama M, Wada M, Harada T, et al: Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias. Blood 92: 4296-4307, 1998.
    • (1998) Blood , vol.92 , pp. 4296-4307
    • Nakayama, M.1    Wada, M.2    Harada, T.3
  • 22
    • 0035902856 scopus 로고    scopus 로고
    • Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
    • Cho M, Uemura H, Kim SC, et al: Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Br J Cancer 85: 563-567, 2001.
    • (2001) Br J Cancer , vol.85 , pp. 563-567
    • Cho, M.1    Uemura, H.2    Kim, S.C.3
  • 23
    • 0036141349 scopus 로고    scopus 로고
    • Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
    • Rosty C, Ueki T, Argani P, et al: Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 160: 45-50, 2002.
    • (2002) Am J Pathol , vol.160 , pp. 45-50
    • Rosty, C.1    Ueki, T.2    Argani, P.3
  • 24
    • 0032731581 scopus 로고    scopus 로고
    • Hypermethylation of tumor suppressor genes in cancer
    • Herman JG: Hypermethylation of tumor suppressor genes in cancer. Semin Cancer Biol 9: 359-367, 2002.
    • (2002) Semin Cancer Biol , vol.9 , pp. 359-367
    • Herman, J.G.1
  • 25
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A: DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21, 2002.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 26
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG and Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054, 2003.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 27
    • 0036281211 scopus 로고    scopus 로고
    • Processing of gene expression data generated by quantitative real-time RT-PCR
    • Muller PY, Janovjak H, Miserez AR and Dobbie Z: Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32: 1372-1379, 2002.
    • (2002) Biotechniques , vol.32 , pp. 1372-1379
    • Muller, P.Y.1    Janovjak, H.2    Miserez, A.R.3    Dobbie, Z.4
  • 28
    • 0028104109 scopus 로고
    • Sp1 elements protect a CpG island from de novo methylation
    • Brandeis M, Frank D, Keshet I, et al: Sp1 elements protect a CpG island from de novo methylation. Nature 371: 435-438, 1994.
    • (1994) Nature , vol.371 , pp. 435-438
    • Brandeis, M.1    Frank, D.2    Keshet, I.3
  • 29
    • 0027960055 scopus 로고
    • Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island
    • Macleod D, Charlton J, Mullins J and Bird AP: Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev 8: 2282-2292, 1994.
    • (1994) Genes Dev , vol.8 , pp. 2282-2292
    • Macleod, D.1    Charlton, J.2    Mullins, J.3    Bird, A.P.4
  • 30
    • 33845606326 scopus 로고    scopus 로고
    • Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue
    • Spizzo G, Gastl G, Obrist P, et al: Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue. Cancer Lett 246: 253-261, 2007.
    • (2007) Cancer Lett , vol.246 , pp. 253-261
    • Spizzo, G.1    Gastl, G.2    Obrist, P.3
  • 31
    • 34249989097 scopus 로고    scopus 로고
    • DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression
    • Tai KY, Shiah SG, Shieh YS, et al: DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression. Oncogene 26: 3989-3997, 2007.
    • (2007) Oncogene , vol.26 , pp. 3989-3997
    • Tai, K.Y.1    Shiah, S.G.2    Shieh, Y.S.3
  • 32
    • 0033678508 scopus 로고    scopus 로고
    • DNA methylation and histone deacetylation in the control of gene expression: Basic biochemistry to human development and disease
    • El-Osta A and Wolffe AP: DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease. Gene Expr 9: 63-75, 2000.
    • (2000) Gene Expr , vol.9 , pp. 63-75
    • El-Osta, A.1    Wolffe, A.P.2
  • 33
    • 0026653420 scopus 로고
    • The essentials of DNA methylation
    • Bird A: The essentials of DNA methylation. Cell 70: 5-8, 1992.
    • (1992) Cell , vol.70 , pp. 5-8
    • Bird, A.1
  • 34
    • 30644472381 scopus 로고    scopus 로고
    • (Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
    • Went P, Vasei M, Bubendorf L, et al: (Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers. Br J Cancer 94: 128-135, 2006.
    • (2006) Br J Cancer , vol.94 , pp. 128-135
    • Went, P.1    Vasei, M.2    Bubendorf, L.3
  • 35
    • 0024535960 scopus 로고
    • Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers
    • Turner R and Tjian R: Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science 243: 1689-1694, 1989.
    • (1989) Science , vol.243 , pp. 1689-1694
    • Turner, R.1    Tjian, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.