The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia

Breast Journal

Volumn 10, Issue 4, 2004, Pages 328-336

  Kessler, Jack H ^a  

^a Symbollon Pharmaceuticals Inc   (United States)

Author keywords

Breast pain; Cyclic mastalgia; Iodine; Lewin breast pain scale; Mastalgia; Molecular iodine

Indexed keywords

IODINE; IOGEN; PLACEBO; SODIUM IODATE; SODIUM IODIDE;

ABDOMINAL PAIN; ACNE; ADULT; ARTICLE; BACKACHE; BREAST FIBROSIS; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DYSPEPSIA; EUTHYROIDISM; FEMALE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MASTALGIA; MULTICENTER STUDY; NAUSEA; PAIN ASSESSMENT; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RASH; SELF REPORT; SINUSITIS; THYROID FUNCTION TEST; UPPER RESPIRATORY TRACT INFECTION; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; BREAST DISEASES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IODINE; MENSTRUAL CYCLE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PATIENT SELECTION; SAFETY;

EID: 3142764631     PISSN: 1075122X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1075-122X.2004.21341.x     Document Type: Article

References (49)

1. Eskin B, Bartusda D, Dunn MR, Jacob G, Dratman MB. Mammary gland dysplasia in iodine deficiency. JAMA 1967;200:115-19.
2. Strum J. Site of iodination in rat mammary gland. Anat Rec 1978;192:235-44.
3. Cann SA, van Netten JP, van Netten C. Hypothesis: iodine, selenium and the development of breast cancer. Cancer Causes Control 2000;11:121-27.
4. Stadel B. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet 1976;1(7965):890-91.
5. Kato N, Funahashi H, Ando K, Takagi H. Suppressive effect of iodine preparations on proliferation of DMBA-induced breast cancer in rat. J Jpn Soc Cancer Ther 1994;29:582-88.
6. Funahashi H, Imai T, Tanaka Y, et al. Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncol 1996;61:209-13.
7. Vishnyakova VV, Mura'yeva NI. On the treatment of dyshormonal hyperplasia of mammary glands. Vestn Akad Med Nauk SSSR 1966;21:19-22.
8. Ghent W, Eskin B. Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993;36:453-60.
9. Ader D, Shriver C. Cyclical mastalgia: prevalence and impact in an outpatient breast clinic sample. J Am Coll Surg 1997;185:466-70.
10. Mansel R, Hughes L. Breast pain and nodularity. In: Hughes LE, Mansel RE, Webster DJT, eds. Benign Disorders and Diseases of the Breast, 2nd ed. London: WB Saunders, 2000:95-121.
11. Wisbey J, Kumar S, Mansel R, Peece P, Pye J, Hughes L. Natural history of breast pain. Lancet 1983;2:672-74.
12. Ader D, Craig D, Shriver C. Update of clinical and research issues in cyclical mastalgia. Breast J 1998;4:25-32.
13. Faiz O, Fentiman I. Management of breast pain. Int J Clin Pract 2000;54:228-32.
14. Mansel R. General discussion: International Symposium on Endocrine Therapy. Horm Res 1989;32:32-34.
15. Thrall K, Bull R. Differences in the distribution of iodine and iodide in the Sprague-Dawley rat. Fund Appl Toxicol 1990;15:75-81.
16. Eskin B, Grotowski C, Connolly C, Ghent W. Different tissue responses for iodine and iodide in rat thyroid and mammary glands. Biol Trace Element Res 1995;49:9-18.
17. Bloor L, Mathias S, Potter L, Tsai J. Validation of a fibrocystic disorder of the breast quality-of-life questionnaire. Drug Inform J 1997;1:31.
18. Benotti J, Benotti N, Pino S, Gardyna H. Determination of total iodine in urine, stool, diets, and tissue. Clin Chem 1965;11:932-36.
19. Gracely R. Pain measurement in man. In: Ng L, Bonica JJ, eds. Pain, Discomfort and Humanitarian Care. Amsterdam: Elsevier/North-Holland, 1980:111-38.
20. Peters F, Pickardt C, Zimmermann G, Breckwoldt M. PRL, TSH, and thyroid hormones in benign breast diseases. Klin Wochenschr 1981;59:403-7.
21. Kumar S, Mansel R, Hughes L, et al. Prolactin response to thyrotropin-releasing hormone stimulation and dopaminergic inhibition in benign breast disease. Cancer 1984;53:1311-15.
22. Ortega-Gonzalez C, Parra A, Barra R, et al. Increased hypothalamic dopaminergic tone only in early parous women with either malignant or benign breast tumors. Endocr Pract 2002;8:89-95.
23. Kumar S, Mansel R, Hughes L, Edwards C, Scanlon M. Prediction of response to endocrine therapy in pronounced cyclical mastalgia using dynamic tests of prolactin release. Clin Endocrinol (Oxf) 1985;23:699-704.
24. Rea N, Bove F, Gentile A, Parmeggiani U. Prolactin response to thyrotropin-releasing hormone as a guideline for cyclical mastalgia treatment. Minerva Med 1997;88:479-87.
25. Estes N. Mastodynia due to fibrocystic disease of the breast controlled with thyroid hormone. Am J Surg 1981;142:764-66.
26. Peters F, Pickardt C, Breckwoldt M. Thyroid hormones in benign breast disease: normalization of exaggerated prolactin responsiveness to thyrotropin-releasing hormone. Cancer 1985;56:1082-85.
27. Rose D, Berke B, Cohen L, Lahti H. A comparison of serum and breast duct fluid-immunoassayable prolactin and growth hormone with bioassayable lactogenic hormones in healthy women and patients with cystic breast disease. Cancer 1987;60:2761-65.
28. Rose D. Hormones and growth factors in nipple aspirates from normal women and benign breast disease patients. Cancer Detect Prev 1992;16:43-51.
29. Vizoso F, Diez-Itza I, Sanchez L, Tuya AF, Ruibal A, Lopez-Otin C. Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women. J Clin Endocrinol Metab 1994;79:525-29.
30. Rillema J, Collins S, Williams C. Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants. Proc Soc Exp Biol Med 2000;224:41-44.
31. Kilbane M, Ajjan R, Weetman A, et al. Tissue iodine content and serum-mediated 1251 uptake-blocking activity in breast cancer. J Clin Endocrinol Metab 2000;85:1245-50.
32. Taurog A. Thyroid peroxidase-catalyzed iodination of thyroglobulin; inhibition by excess iodide. Arch Biochem Biophys 1970;139:212-20.
33. Lamas L, Santisteban P, Turmo C, Seguido A. Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration. Endocrinology 1986;118:2131-36.
34. Hickey J, Panicucci R, Duan Y, et al. Control of the amount of free molecular iodine in iodine germicides. J Pharm Pharmacol 1997;49:1195-99.
35. Wildberger E, Kohler H, Jenzer H, Kampf J, Studer H. Inactivation of peroxidase and glucose oxidase by H202 and iodide during in vitro thyroglobulin iodination. Mol Cell Endocrinol 1986;46:149-54.
36. Boeynaems JM, Watson J, Oates J, Hubbard W. Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an iodolactone. Lipids 1981;16:323-27.
37. Pisarev M, Degroot L, Hati R. KI and imidazole inhibition of TSH and c-AMP induced thyroidal iodine secretion. Endocrinology 1971;88:1217-21.
38. Ingbar SH. Autoregulation of the thyroid. Response to iodide excess and depletion. Mayo Clin Proc 1972;47:814-23.
39. Gartner R, Schopohl D, Schaefer S, et al. Regulation of transforming growth factor beta 1 messenger ribonucleic acid expression in porcine thyroid follicles in vitro by growth factors, iodine, or delta-iodolactone. Thyroid 1997;7:633-40.
40. Panneels V, Van Sande J, Vanden Bergen H, et al. Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes. Mol Cell Endocrinol 1994;106:41-50.
41. Eskin BA. Iodine metabolism and breast cancer. Trans N Y Acad Sci 1970;32:911-47.
42. Smyth P. The thyroid and breast cancer: a significant association?. Ann Med 1997;29:189-91.
43. Stadel B. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet 1976;1:890-91.
44. Venturi S, Donati F, Venturi A, Venturi M, Grossi L, Guidi A. Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach. Adv Clin Pathol 2000;4:11-17.
45. Venturi S. Is there a role for iodine in breast diseases?. Breast 2001;10:379-82.
46. Cann SA, van Netten JP, Glover DW. Iodide accumulation in extrathyroidal tissues. J Clin Endocrinol Metab 1999;84:821-22.
47. Goodwin PJ, DeBoer G, Clark R, et al. Cyclical mastopathy and premenopausal breast cancer risk. Results of a case-control study. Breast Cancer Res Treat 1995;33:63-73.
48. McDivitt R, Stevens J, Lee NC, Wingo P, Rubin G, Gersell D. Histologic types of benign breast disease and the risk for breast cancer. The Cancer and Steroid Hormone Study Group. Cancer 1992;69:1408-14.
49. Minami Y, Ohuchi N, Taeda Y, et al. Risk of breast cancer in Japanese women with benign breast disease. Jpn J Cancer Res 1999;90:600-606.