-
1
-
-
77954869642
-
Epidemiological trends of cutaneous malignant melanoma: Incidence of cutaneous malignant melanoma
-
Available at, Accessed February
-
Lens MB, Dawes M. Epidemiological trends of cutaneous malignant melanoma: incidence of cutaneous malignant melanoma. Medscape Today. Available at: http://www.medscape.com/viewarticle/470300_2. Accessed February 2, 2010.
-
(2010)
Medscape Today
, pp. 2
-
-
Lens, M.B.1
Dawes, M.2
-
2
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59(4):225-249.
-
(2009)
CA Cancer J Clin
, vol.59
, Issue.4
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
3
-
-
53949089178
-
State of the science 60th anniversary review: 60 years of advances in cutaneous melanoma epidemiology, diagnosis, and treatment, as reported in the journal Cancer
-
Demierre MF, Sabel MS, Margolin KA, Daud AI, Sondak VK. State of the science 60th anniversary review: 60 years of advances in cutaneous melanoma epidemiology, diagnosis, and treatment, as reported in the journal Cancer. Cancer. 2008;113(7)(suppl): 1728-1743.
-
(2008)
Cancer
, vol.113
, Issue.7 SUPPL.
, pp. 1728-1743
-
-
Demierre, M.F.1
Sabel, M.S.2
Margolin, K.A.3
Daud, A.I.4
Sondak, V.K.5
-
5
-
-
0032541650
-
Increasing complexity of Ras signaling
-
11 Reviews
-
Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signaling. Oncogene. 1998;17(11 Reviews):1395-1413.
-
(1998)
Oncogene
, vol.17
, pp. 1395-1413
-
-
Campbell, S.L.1
Khosravi-Far, R.2
Rossman, K.L.3
Clark, G.J.4
Der, C.J.5
-
6
-
-
0034085811
-
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
-
Tsao H, Zhang X, Fowlkes K, Haluska FG. Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res. 2000;60(7):1800-1804.
-
(2000)
Cancer Res
, vol.60
, Issue.7
, pp. 1800-1804
-
-
Tsao, H.1
Zhang, X.2
Fowlkes, K.3
Haluska, F.G.4
-
7
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-2147.
-
(2005)
N Engl J Med
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
-
8
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-954.
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
9
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7(8):606-619.
-
(2006)
Nat Rev Genet
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
10
-
-
1342321750
-
PI 3-kinase, Akt and cell survival
-
Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol. 2004;15(2):177-182.
-
(2004)
Semin Cell Dev Biol
, vol.15
, Issue.2
, pp. 177-182
-
-
Downward, J.1
-
11
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A. 1999;96(8):4240-4245.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.8
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
12
-
-
0037115394
-
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kB and tumor progression
-
Dhawan P, Singh AB, Ellis DL, Richmond A. Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kB and tumor progression. Cancer Res. 2002;62(24):7335-7342.
-
(2002)
Cancer Res
, vol.62
, Issue.24
, pp. 7335-7342
-
-
Dhawan, P.1
Singh, A.B.2
Ellis, D.L.3
Richmond, A.4
-
13
-
-
0012746941
-
Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
-
Reifenberger J, Wolter M, Boström J, et al. Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas. Virchows Arch. 2000;436(5):487-493.
-
(2000)
Virchows Arch
, vol.436
, Issue.5
, pp. 487-493
-
-
Reifenberger, J.1
Wolter, M.2
Boström, J.3
-
14
-
-
0030777104
-
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
-
Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res. 1997;57(17):3660-3663.
-
(1997)
Cancer Res
, vol.57
, Issue.17
, pp. 3660-3663
-
-
Guldberg, P.1
Straten, P.T.2
Birck, A.3
Ahrenkiel, V.4
Kirkin, A.F.5
Zeuthen, J.6
-
15
-
-
0034086867
-
Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies
-
Birck A, Ahrenkiel V, Zeuthen J, Hou-Jensen K, Guldberg P. Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. J Invest Dermatol. 2000;114(2):277-280.
-
(2000)
J Invest Dermatol
, vol.114
, Issue.2
, pp. 277-280
-
-
Birck, A.1
Ahrenkiel, V.2
Zeuthen, J.3
Hou-Jensen, K.4
Guldberg, P.5
-
16
-
-
0033819340
-
Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
-
Zhou XP, Gimm O, Hampel H, Niemann T, Walker MJ, Eng C. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol. 2000;157(4):1123-1128.
-
(2000)
Am J Pathol
, vol.157
, Issue.4
, pp. 1123-1128
-
-
Zhou, X.P.1
Gimm, O.2
Hampel, H.3
Niemann, T.4
Walker, M.J.5
Eng, C.6
-
17
-
-
53849132331
-
A novel AKT3 mutation in melanoma tumours and cell lines
-
Davies MA, Stemke-Hale K, Tellez C, et al. A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer. 2008;99(8):1265-1268.
-
(2008)
Br J Cancer
, vol.99
, Issue.8
, pp. 1265-1268
-
-
Davies, M.A.1
Stemke-Hale, K.2
Tellez, C.3
-
18
-
-
14944352371
-
Prognostic significance of activated Akt expression in melanoma: A clinicopathologic study of 292 cases
-
Dai DL, Martinka M, Li G. Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. J Clin Oncol. 2005;23(7):1473-1482.
-
(2005)
J Clin Oncol
, vol.23
, Issue.7
, pp. 1473-1482
-
-
Dai, D.L.1
Martinka, M.2
Li, G.3
-
19
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 1995;83(6):993-1000.
-
(1995)
Cell
, vol.83
, Issue.6
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
20
-
-
33847282821
-
Features associated with germline CDKN2A mutations: A GenoMEL study of melanoma-prone families from three continents
-
Goldstein AM, Chan M, Harland M, et al. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet. 2007;44(2):99-106.
-
(2007)
J Med Genet
, vol.44
, Issue.2
, pp. 99-106
-
-
Goldstein, A.M.1
Chan, M.2
Harland, M.3
-
21
-
-
0029664339
-
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
-
Zuo L, Weger J, Yang Q, et al. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet. 1996;12(1):97-99.
-
(1996)
Nat Genet
, vol.12
, Issue.1
, pp. 97-99
-
-
Zuo, L.1
Weger, J.2
Yang, Q.3
-
22
-
-
0038457556
-
Microphthalamia-associated transcription factor: A critical regulator of pigment cell development and survival
-
Widlund HR, Fisher DE. Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene. 2003;22(20):3035-3041.
-
(2003)
Oncogene
, vol.22
, Issue.20
, pp. 3035-3041
-
-
Widlund, H.R.1
Fisher, D.E.2
-
23
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway LA, Widlund HR, Rubin MA, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436(7047):117-122.
-
(2005)
Nature
, vol.436
, Issue.7047
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
-
24
-
-
0023694835
-
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
-
Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988;335(6185):88-89.
-
(1988)
Nature
, vol.335
, Issue.6185
, pp. 88-89
-
-
Chabot, B.1
Stephenson, D.A.2
Chapman, V.M.3
Besmer, P.4
Bernstein, A.5
-
25
-
-
0024280901
-
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
-
Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell. 1988;55(1):185-192.
-
(1988)
Cell
, vol.55
, Issue.1
, pp. 185-192
-
-
Geissler, E.N.1
Ryan, M.A.2
Housman, D.E.3
-
26
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
Curtin JA, Busam K, Pinkel D, Bastian BC. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006;24(26):4340-4346.
-
(2006)
J Clin Oncol
, vol.24
, Issue.26
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
27
-
-
0032531854
-
The National Cancer Data Base report on cutaneous and noncutaneous melanoma: A summary of 84,836 cases from the past decade
-
American College of Surgeons Commission on Cancer and the American Cancer Society
-
Chang AE, Karnell LH, Menck HR; American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. Cancer. 1998;83(8):1664-1678.
-
(1998)
Cancer
, vol.83
, Issue.8
, pp. 1664-1678
-
-
Chang, A.E.1
Karnell, L.H.2
Menck, H.R.3
-
28
-
-
39749174411
-
Molecular pathways mediating liver metastasis in patients with uveal melanoma
-
Bakalian S, Marshall JC, Logan P, et al. Molecular pathways mediating liver metastasis in patients with uveal melanoma. Clin Cancer Res. 2008;14(4):951-956.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.4
, pp. 951-956
-
-
Bakalian, S.1
Marshall, J.C.2
Logan, P.3
-
30
-
-
59049107421
-
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
-
Van Raamsdonk CD, Bezrookove V, Green G, et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature. 2009;457(7229):599-602.
-
(2009)
Nature
, vol.457
, Issue.7229
, pp. 599-602
-
-
Raamsdonk, C.D.V.1
Bezrookove, V.2
Green, G.3
-
31
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer. 2007;7(2):79-94.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.2
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
32
-
-
33846682938
-
Chemotherapy for metastatic melanoma: Time for a change?
-
Gogas HJ, Kirkwood JM, Sondak VK. Chemotherapy for metastatic melanoma: time for a change? Cancer. 2007;109(3):455-464.
-
(2007)
Cancer
, vol.109
, Issue.3
, pp. 455-464
-
-
Gogas, H.J.1
Kirkwood, J.M.2
Sondak, V.K.3
-
33
-
-
63249105225
-
Oncogenic Braf induces melanocyte senescence and melanoma in mice
-
Dhomen N, Reis-Filho JS, da Rocha Dias S, et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell. 2009;15(4):294-303.
-
(2009)
Cancer Cell
, vol.15
, Issue.4
, pp. 294-303
-
-
Dhomen, N.1
Reis-Filho, J.S.2
Rocha, D.S.D.3
-
34
-
-
63849114060
-
Benign nodal nevi frequently harbor the activating V600E BRAF mutation
-
Taube JM, Begum S, Shi C, Eshleman JR, Westra WH. Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am J Surg Pathol. 2009;33(4):568-571.
-
(2009)
Am J Surg Pathol
, vol.33
, Issue.4
, pp. 568-571
-
-
Taube, J.M.1
Begum, S.2
Shi, C.3
Eshleman, J.R.4
Westra, W.H.5
-
35
-
-
67349212438
-
Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice
-
Goel VK, Ibrahim N, Jiang G, et al. Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene. 2009;28(23):2289-2298.
-
(2009)
Oncogene
, vol.28
, Issue.23
, pp. 2289-2298
-
-
Goel, V.K.1
Ibrahim, N.2
Jiang, G.3
-
36
-
-
65649147543
-
V600E cooperates with Pten loss to elicit metastatic melanoma
-
V600E cooperates with Pten loss to elicit metastatic melanoma. Nat Genet. 2009;41(5):544-552.
-
(2009)
Nat Genet
, vol.41
, Issue.5
, pp. 544-552
-
-
Dankort, D.1
Curley, D.P.2
Cartlidge, R.A.3
-
37
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64(19):7099-7109.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
38
-
-
33748325763
-
Sorafenib in advanced melanoma: A phase II randomised discontinuation trial analysis
-
Eisen T, Ahmad T, Flaherty KT, et al. Sorafenib in advanced melanoma: a phase II randomised discontinuation trial analysis. Br J Cancer. 2006;95(5):581-586.
-
(2006)
Br J Cancer
, vol.95
, Issue.5
, pp. 581-586
-
-
Eisen, T.1
Ahmad, T.2
Flaherty, K.T.3
-
39
-
-
43749110700
-
Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 Study Group
-
McDermott DF, Sosman JA, Gonzalez R, et al. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol. 2008;26(13):2178-2185.
-
(2008)
J Clin Oncol
, vol.26
, Issue.13
, pp. 2178-2185
-
-
McDermott, D.F.1
Sosman, J.A.2
Gonzalez, R.3
-
40
-
-
76649142577
-
Phase I/II study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma
-
Abstract, Abstract 9026
-
Kim KB, Davies MA, Papadopoulos NE, et al. Phase I/II study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma [abstract]. J Clin Oncol. 2009;27(15)(suppl). Abstract 9026.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Kim, K.B.1
Davies, M.A.2
Papadopoulos, N.E.3
-
41
-
-
67651246671
-
Phase I study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
-
Abstract, Abstract 9000
-
Flaherty K, Puzanov I, Sosman J, et al. Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer [abstract]. J Clin Oncol. 2009;27(15)(suppl). Abstract 9000.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Flaherty, K.1
Puzanov, I.2
Sosman, J.3
-
42
-
-
37249013214
-
-
A study of RO5185426 in previously treated patients with metastatic melanoma, Available at, Accessed January
-
A study of RO5185426 in previously treated patients with metastatic melanoma. ClinicalTrials.gov. Available at: http://www.clinicaltrials.gov/ct2/show/NCT00949702?term=RO5185426&rank=2. Accessed January 30, 2010.
-
(2010)
ClinicalTrials.gov
, pp. 30
-
-
-
44
-
-
43749103335
-
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei AA, Cohen RB, Franklin W, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 2008;26(13):2139-2146.
-
(2008)
J Clin Oncol
, vol.26
, Issue.13
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
-
45
-
-
65649108998
-
AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: An open-label, randomized, multicenter, phase II study
-
Abstract, Abstract 9033
-
Dummer R, Robert C, Chapman PB, et al. AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: an open-label, randomized, multicenter, phase II study [abstract]. J Clin Oncol. 2008;26(15)(suppl). Abstract 9033.
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Dummer, R.1
Robert, C.2
Chapman, P.B.3
-
46
-
-
37249013214
-
-
Brief title: study to determine effectiveness of GSK1120212 in BRAF mutation-positive melanoma subjects previously treated with a BRAF inhibitor, Available at, Accessed February
-
Brief title: study to determine effectiveness of GSK1120212 in BRAF mutation-positive melanoma subjects previously treated with a BRAF inhibitor. ClinicalTrials.gov. Available at: http://www.clinicaltrials.gov/ct2/show/NCT01037127?term5NCT01037127&rank51. Accessed February 2, 2010.
-
(2010)
ClinicalTrials.gov
, pp. 2
-
-
-
47
-
-
66149090765
-
Molecular pathogenesis of cutaneous melanocytic neoplasms
-
Ibrahim N, Haluska FG. Molecular pathogenesis of cutaneous melanocytic neoplasms. Annu Rev Pathol. 2009;4:551-579.
-
(2009)
Annu Rev Pathol
, vol.4
, pp. 551-579
-
-
Ibrahim, N.1
Haluska, F.G.2
-
48
-
-
40649126759
-
MTOR is activated in the majority of malignant melanomas
-
Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP. mTOR is activated in the majority of malignant melanomas. J Invest Dermatol. 2008;128(4):980-987.
-
(2008)
J Invest Dermatol
, vol.128
, Issue.4
, pp. 980-987
-
-
Karbowniczek, M.1
Spittle, C.S.2
Morrison, T.3
Wu, H.4
Henske, E.P.5
-
49
-
-
23844476134
-
CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium
-
Margolin K, Longmate J, Baratta T, et al. CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer. 2005;104(5):1045-1048.
-
(2005)
Cancer
, vol.104
, Issue.5
, pp. 1045-1048
-
-
Margolin, K.1
Longmate, J.2
Baratta, T.3
-
50
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira SM, Stauffer F, Brueggen J, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther. 2008;7(7):1851-1863.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.7
, pp. 1851-1863
-
-
Maira, S.M.1
Stauffer, F.2
Brueggen, J.3
-
51
-
-
21044460131
-
Lack of clinical efficacy of imatinib in metastatic melanoma
-
Ugurel S, Hildenbrand R, Zimpfer A, et al. Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer. 2005;92(8):1398-1405.
-
(2005)
Br J Cancer
, vol.92
, Issue.8
, pp. 1398-1405
-
-
Ugurel, S.1
Hildenbrand, R.2
Zimpfer, A.3
-
52
-
-
33646268037
-
Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
-
Wyman K, Atkins MB, Prieto V, et al. Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer. 2006;106(9):2005-2011.
-
(2006)
Cancer
, vol.106
, Issue.9
, pp. 2005-2011
-
-
Wyman, K.1
Atkins, M.B.2
Prieto, V.3
-
53
-
-
50249141632
-
Phase II trial of imatinib mesylate in patients with metastatic melanoma
-
Kim KB, Eton O, Davis DW, et al. Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer. 2008;99(5):734-740.
-
(2008)
Br J Cancer
, vol.99
, Issue.5
, pp. 734-740
-
-
Kim, K.B.1
Eton, O.2
Davis, D.W.3
-
54
-
-
42949128595
-
Major response to imatinib mesylate in KIT-mutated melanoma
-
Hodi FS, Friedlander P, Corless CL, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol. 2008;26(12):2046-2051.
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 2046-2051
-
-
Hodi, F.S.1
Friedlander, P.2
Corless, C.L.3
-
55
-
-
47249099056
-
Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
-
Lutzky J, Bauer J, Bastian BC. Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res. 2008;21(4):492-493.
-
(2008)
Pigment Cell Melanoma Res
, vol.21
, Issue.4
, pp. 492-493
-
-
Lutzky, J.1
Bauer, J.2
Bastian, B.C.3
-
56
-
-
68949132133
-
A phase II study of imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT [abstract]
-
Abstract, Abstract 9001
-
Carvajal RD, Chapman PB, Wolchok JD, et al. A phase II study of imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT [abstract]. J Clin Oncol. 2009;27(15)(suppl). Abstract 9001.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Carvajal, R.D.1
Chapman, P.B.2
Wolchok, J.D.3
-
57
-
-
0034773992
-
The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
-
Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer. 2001;37(suppl 4):S3-S8.
-
(2001)
Eur J Cancer
, vol.37
, Issue.SUPPL 4
, pp. 3-8
-
-
Yarden, Y.1
-
58
-
-
0032986967
-
Differential expression of epidermal growth factor receptor in melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization
-
Sparrow LE, Heenan PJ. Differential expression of epidermal growth factor receptor in melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization. Australas J Dermatol. 1999;40(1):19-24.
-
(1999)
Australas J Dermatol
, vol.40
, Issue.1
, pp. 19-24
-
-
Sparrow, L.E.1
Heenan, P.J.2
-
59
-
-
0025316234
-
Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma
-
published correction appears in N Engl J Med. 1990;323(18):1283
-
Trent JM, Meyskens FL, Salmon SE, et al. Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma [published correction appears in N Engl J Med. 1990;323(18):1283]. N Engl J Med. 1990;322(21):1508-1511.
-
(1990)
N Engl J Med
, vol.322
, Issue.21
, pp. 1508-1511
-
-
Trent, J.M.1
Meyskens, F.L.2
Salmon, S.E.3
-
60
-
-
34548692277
-
EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosis
-
Rákosy Z, Vízkeleti L, Ecsedi S, et al. EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosis. Int J Cancer. 2007;121(8):1729-1737.
-
(2007)
Int J Cancer
, vol.121
, Issue.8
, pp. 1729-1737
-
-
Rákosy, Z.1
Vízkeleti, L.2
Ecsedi, S.3
-
61
-
-
44949117528
-
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
-
Ueno Y, Sakurai H, Tsunoda S, et al. Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells. Int J Cancer. 2008;123(2):340-347.
-
(2008)
Int J Cancer
, vol.123
, Issue.2
, pp. 340-347
-
-
Ueno, Y.1
Sakurai, H.2
Tsunoda, S.3
-
62
-
-
67849099218
-
ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: Inhibition by gefitinib (ZD1839)
-
Djerf EA, Trinks C, Abdiu A, Thunell LK, Hallbeck EL, Waltz TM. ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: inhibition by gefitinib (ZD1839). Melanoma Res. 2009;19(3):156-166.
-
(2009)
Melanoma Res
, vol.19
, Issue.3
, pp. 156-166
-
-
Djerf, E.A.1
Trinks, C.2
Abdiu, A.3
Thunell, L.K.4
Hallbeck, E.L.5
Waltz, T.M.6
-
63
-
-
70350110307
-
NRG1/ERBB3 signaling in melanocyte development and melanoma: Inhibition of differentiation and promotion of proliferation
-
Buac K, Xu M, Cronin J, Weeraratna AT, Hewitt SM, Pavan WJ. NRG1/ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation. Pigment Cell Melanoma Res. 2009;22(6):773-784.
-
(2009)
Pigment Cell Melanoma Res
, vol.22
, Issue.6
, pp. 773-784
-
-
Buac, K.1
Xu, M.2
Cronin, J.3
Weeraratna, A.T.4
Hewitt, S.M.5
Pavan, W.J.6
-
64
-
-
0031064598
-
Signal transduction by the oncogenic receptor tyrosine kinase Xmrk in melanoma formation of Xiphophorus
-
Wellbrock C, Gómez A, Schartl M. Signal transduction by the oncogenic receptor tyrosine kinase Xmrk in melanoma formation of Xiphophorus. Pigment Cell Res. 1997;10(1-2):34-40.
-
(1997)
Pigment Cell Res
, vol.10
, Issue.1-2
, pp. 34-40
-
-
Wellbrock, C.1
Gómez, A.2
Schartl, M.3
-
65
-
-
70349556805
-
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
-
Prickett TD, Agrawal NS, Wei X, et al. Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet. 2009;41(10):1127-1132.
-
(2009)
Nat Genet
, vol.41
, Issue.10
, pp. 1127-1132
-
-
Prickett, T.D.1
Agrawal, N.S.2
Wei, X.3
-
66
-
-
77954872229
-
Phase II study of erlotinib given daily for patients with metastatic melanoma (MM)
-
Abstract 18002
-
Wyman K, Kelley M, Puzanov I, et al. Phase II study of erlotinib given daily for patients with metastatic melanoma (MM) [abstract]. J Clin Oncol. 2006;24(18)(suppl). Abstract 18002.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 SUPPL.
-
-
Wyman, K.1
Kelley, M.2
Puzanov, I.3
-
67
-
-
71649098671
-
A phase II study of gefitinib in patients with metastatic melanoma
-
Abstract, Abstract 9057
-
Patel S, Bedikian A, Kim K, et al. A phase II study of gefitinib in patients with metastatic melanoma [abstract]. J Clin Oncol. 2009;27(15)(suppl). Abstract 9057.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Patel, S.1
Bedikian, A.2
Kim, K.3
-
68
-
-
41149148128
-
A multicenter phase II study of erlotinib and bevacizumab in patients with metastatic melanoma
-
Abstract 8539
-
Wyman K, Spigel D, Puzanov I, et al. A multicenter phase II study of erlotinib and bevacizumab in patients with metastatic melanoma [abstract]. J Clin Oncol. 2007;25(18)(suppl). Abstract 8539.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Wyman, K.1
Spigel, D.2
Puzanov, I.3
-
69
-
-
38549115197
-
The Met tyrosine kinase receptor in development and cancer
-
Gentile A, Trusolino L, Comoglio PM. The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev. 2008;27(1):85-94.
-
(2008)
Cancer Metastasis Rev
, vol.27
, Issue.1
, pp. 85-94
-
-
Gentile, A.1
Trusolino, L.2
Comoglio, P.M.3
-
70
-
-
0036993573
-
Melanoma development and progression: A conspiracy between tumor and host
-
Hsu MY, Meier F, Herlyn M. Melanoma development and progression: a conspiracy between tumor and host. Differentiation. 2002;70(9-10):522-536.
-
(2002)
Differentiation
, vol.70
, Issue.9-10
, pp. 522-536
-
-
Hsu, M.Y.1
Meier, F.2
Herlyn, M.3
-
71
-
-
56849116168
-
Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: Intercorrelation and prognostic implications
-
Economou MA, All-Ericsson C, Bykov V, et al. Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications. Acta Ophthalmol. 2008;86(thesis 4):20-25.
-
(2008)
Acta Ophthalmol
, vol.86
, Issue.THESIS 4
, pp. 20-25
-
-
Economou, M.A.1
All-Ericsson, C.2
Bykov, V.3
-
72
-
-
77954873690
-
-
ClinicalTrials.gov, Available at:, Accessed January 31
-
Study of XL184 in adults with advanced malignancies. ClinicalTrials.gov. Available at: http://www.clinicaltrials.gov/ct2/show/study/NCT00940225?term=xl184&rank=1&show_locs=Y#locn. Accessed January 31, 2010.
-
(2010)
Study of XL184 in adults with advanced malignancies
-
-
-
73
-
-
33845573525
-
A phase I study of a novel spectrum selective kinase inhibitor (SSKI), XL880, administered orally in patients (pts) with advanced solid tumors (STs) [abstract]
-
Abstract, Abstract 3041
-
Eder JP, Appleman L, Heath E, et al. A phase I study of a novel spectrum selective kinase inhibitor (SSKI), XL880, administered orally in patients (pts) with advanced solid tumors (STs) [abstract]. J Clin Oncol. 2006;24(18)(suppl). Abstract 3041.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 SUPPL.
-
-
Eder, J.P.1
Appleman, L.2
Heath, E.3
-
74
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
Emery CM, Vijayendran KG, Zipser MC, et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci U S A. 2009;106(48):20411-20416.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.48
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
|