Signal Transduction by the Oncogenic Receptor Tyrosine Kinase Xmrk in Melanoma Formation of Xiphophorus

Pigment Cell Research

Volumn 10, Issue 1-2, 1997, Pages 34-40

  Wellbrock, Claudia ^a   Gómez, Ana ^a   Schartl, Manfred ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Growth factor receptor; Melanoma; Proliferation; Signal transduction; Tyrosine kinases

Indexed keywords

XIPHOPHORUS;

FISH PROTEIN; GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; XMRK PROTEIN, XIPHOPHORUS;

ANIMAL; CYPRINODONTIFORMES; GENETICS; HUMAN; MELANOMA; METABOLISM; ONCOGENE; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CYPRINODONTIFORMES; FISH PROTEINS; HUMANS; MELANOMA; ONCOGENES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 0031064598     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0749.1997.tb00463.x     Document Type: Article

References (60)

1. Aaronson, S.A. (1991) Growth factors and cancer. Science, 254:1146-1153.
2. Adam, D., W. Mäueler, and M. Schartl (1991) Transcriptional activation of the melanoma inducing Xmrk oncogene in Xiphophorus. Oncogene, 6:73-80.
3. Adam, D., N. Dimitrijevic, and M. Schartl (1993) Tumor suppression in Xiphophorus by an accidentally acquired promoter. Science, 259:816-819.
4. Adelaide, J., M-G. Mattel, I. Maries, F. Raybaud, J. Planche, O. De Lapeyriere, and D. Birnbaum (1988) Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in human melanoma. Oncogene, 2:413-416.
5. Ahuja, M.R. and F. Anders (1976) A genetic concept of the origin of cancer, based in part upon studies of neoplasms in fishes. Prog. Exp. Tumor Res., 20:380-397.
6. Albino, A.P, D.M. Nanus, I.R. Mentle, C. Cordon-Cardo, N.S. McNutt, J. Bressler, and M. Andreeff (1989) Analysis of ras oncogenes in malignant melanoma and precursor lesions: Correlation point mutations with differentiation phenotype. Oncogene, 4:1363-1374.
7. Albino, A.P., B.M. Davis, and D.M. N anus (1991) Induction of growth factor RNA expression in human malignant melanoma: Markers for transformation. Cancer Res., 51:4815-4820.
8. Anders, A. and F. Anders (1978) Etiology of cancer as studied in the platyfish-swordtail system. Biochim. Biophys. Acta, 516:61-95.
9. Anders X. (1991) Contributions of the Gordon-Kosswig melanoma system to the present concept of neoplasia. Pig,. Cell Res., 4:7-29.
10. Barnekow, A., M. Schartl, F. Anders, and H. Bauer (1982) Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein. Cancer Res., 42:2429-2433.
11. Barnekow, A., E. Paul, and M. Schartl (1987) Expression of the c-src protooncogene in human skin tumors. Cancer Res., 47:235-240.
12. Becker, D., P.L. Lee, U. Rodeck, and M. Heryn (1992) Inhibition of the fibroblast growth factor receptor 1 (FGFR-1) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation. Oncogene, 7:2303-2313.
13. Cohen, G.B., R. Ren, and D. Baltimore (1995) Modular binding domains in signal transduction. Cell, 62:481-492.
14. Dotto, G.P, G. Moellinan, S. Ghosh, M. Edwards, and R. Halaban (1989) Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. J. Cell. Biol., 109:3115-3128.
15. Easty, D.J., S.E. Ganz, C.J. Farr, C. Lai, M. Herlyn, and D.C. Bennett (1993) Novel and known protein tyrosine kinase and their abnormal expression in human melanoma. J. Invest. Dermatol., 101:679-684.
16. Easty, D.J., M. Herlyn, D.C. Bennett (1995) Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int. J. Cancer, 60:129-136.
17. FitzGerald, M.G., D.P Harkin, S. Silva-Arrieta, D.J. MacDonald, L.C. Lucchina, H. Unsal, E. O'Neill, J. Koh, D.M. Finkelstein, K.J. Isselbacher, A. J. Sober, and D.A. Haber (1996) Prevalence of germline mutations in p16, p19ARF, and CDK4 in familial melanoma: Analysis of a clinic-based population. Proc. Natl. Acad. Sci. U.S.A. 93:8541-8545.
18. Förnzler, D., J. Altschmied, I. Nanda, R. Kolb, M. Baudler, M. Schmid, and M. Schartl (1996) The Xmrk oncogene promoter is derived from a novel amplified locus of unusual organization. Genome Res., 6:102-113.
19. Funasaka, Y., T. Boulton, M. Cobb, Y Yarden, B. Fan, S.D. Lyman, D.E. Williams, D.M. Anderson, R. Zakut, Y. Mishima, and R. Halaban (1992) c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Mol. Biol. Cell., 3:197-209.
20. Gordon, M. (1927) The genetics of viviparous top-minnow Platypoecilus: The inheritance of two kinds of melanophores. Genetics, 12:253-283.
21. Green, A., A. Shilkaitis, L. Brateseu, M.S. Amoss, Jr., and C.W Beattie (1992) Establishment and characterization of four Sinclair swine cutaneous malignant melanoma cell lines. Cancer Genet. Cytogenet., 61:77-92.
22. Gutman, M., R.K. Singh, R. Randinsky, and M. Bar-Eli (1994) Intertumoral heterogeneity of receptor-tyrosine kinases expression in human melanoma cell lines with different metaetatic capabilities. Anticancer Res., 14:1759-1765.
23. Halaban, R. (1994) Signal transduction in normal and malignant melanocytes. Pigment. Cell. Res., 7:89-95.
24. Halaban, R., B.S. Kwon, S. Ghosh, P. Delli Bovi, and A. Baird (1988) bFGF as an autocrine growth factor for human melanoma. Oncogene Res., 3:177-186.
25. Halaban, R., J.S. Rubin, Y. Funasaka, M. Cobb, T. Boulton, D. Faletto, E. Rosen, A. Chan, K. Yoko, W White, C. Cook, and G. Moellmann (1992) Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells. Oncogene, 7:2195-2206.
26. Hill, C.S. and R. Treisman (1995) Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell, 80:199-211.
27. Iwamoto, T., M. Takahashi, M. Ito, K. Hamatani, M. Ohbayashi, W. Wajjwalku, K. Isobe, and I. Nakashima (1991) Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 10:3167-3175.
28. Komada, M. and N. Kitamura (1993) The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor. Oncogene, 8:2381-2390.
29. Kosswig, C. (1928) Über Kreuzungen zwischen den Teleostiern Xiphophorus helleri und Platypoecilus maculatus. Z. Indukt. Abstammungs-Vererbungsl., 47:150-158.
30. Kraetm, G.M., M. Schartl, and R.U. Peter (1995) Human malignant melanoma. A genetic disease? Cancer, 75:1228-1237.
31. Lassam, N. and S. Bickford (1992) Loss of c-kit expression in cultured melanoma cells. Oncogene, 7:51-56.
32. Li, N., A. Batzer, R. Daly, V Yajnik, E. Skolnik, P. Chardin, D. Bar-Sagi, B. Margolis, and J. Schlessinger (1993) Guanine-nucleotide releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to ras signalling. Nature, 363:85-88.
33. Loganzo, F., J.S. Dosik, Y. Zhao, M.J. Vidai, D.M. Nanus, M. Sudol, and A.P. Albino (1993) Elevated expression of tyrosine kinase c-yes, but not c-src, in human malignant melanoma. Oncogene, 8:2637-2644.
34. c-sre with two major signaling pathways in human breast cancer. Proc. Natl. Acad. Sci. U.S.A., 91:83-87.
35. Malitschek, B., J. Wittbrodt, P. Fischer, R. Lammers, A. Ullrich, and M. Schartl (1994) Autocrine stimulation of the Xmrk receptor tyrosine kinase in Xiphophorus melanoma cells and identification of a source for the ligand. J. Biol. Chem., 14:10423-10430.
36. Mäueler, W., A. Schartl, and M. Schartl (1993) Different expression patterns of oncogenes and proto-oncogenes in hereditary and carcinogen-induced tumors of Xiphophorus. Int. J. Cancer, 55:288-296.
37. Muthuswamy, S.K. and W.J. Muller (1994) Activation of src family kinases in Neu-induced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo. Oncogene, 11:1801-1810.
38. Nanda, I., S. Weis, D. Förnzler, J. Altschmied, M. Schartl, and M. Schmid (1996) Clustered organization and conservation of the Xiphophorus maculatus D locus, which includes two distinct gene sequences. Chromosome, 105:242-249.
39. Natali, P.G., M.R. Nicotra, A.B. Winkler, R. Cavaliere, A. Bigotti, and A. Ullrich (1992) Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int. J. Cancer, 52:197-201.
40. Nocka, K., J.C. Tan, E. Chiu, T.Y. Chu, P Ray, P. Traktman, and P. Besmer (1990) Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W87, Wv, W41 and W. EMBO J. 9:1085-1813.
41. Pawson, T. (1995) Protein modules and signalling networks. Nature 12:573-580.
42. Quong, R.Y., S.T. Bickford, Y.L. Ing, B. Terman, M. Herlyn, and N.J. Lassam (1994) Protein kinases in normal and transformed melanocytes. Melanoma Res., 4:313-319.
43. Reed, J.A., F. Loganzo, Jr., C.R. Shea, G.J. Walker, J.F. Flores, J.M. Glendening, J.K. Bogdany, J. Shiel, F.G. Haluska, J.W. Fountain, and A.P. Albino (1995) Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res., 55:2713-2718.
44. Rodeck, U., K. Melber, R. Kath, H.D. Menssen, M. Varello, B. Atkinson, and M. Herlyn. Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes. J. Invest. Dermatol., 97:20-26.
45. Rodrigues, G.A. and M. Park (1994) Oncogenic activation of tyrosine kinases. Curr. Opin. Genet. Dev., 4:15-24.
46. Rotin, D., B. Margolis, M. Mohammadi, R.J. Daly, G. Daum, N. Li, E. Fischer, W. Burgess, A. Ullrich, and J. Schlessinger (1992) SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: Identification of Tyr992 as the high affinity binding site for the SH2 domains of phospholipase Cγ. EMBO J., 11:559-567.
47. Rozakis-Adcock, M., R. Fernley, J. Wade, T. Pawson, and D. Bowtell (1993) The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the ras activator mSos1. Nature, 363:83-85.
48. Schartl, M., A. Barnekow, H. Bauer, and F. Anders (1982) Correlation of inheritance and expression between a tumor gene and the cellular homolog of the Rous sarcoma virus-transforming gene in Xiphophorus. Cancer Res., 42:4222-4227.
49. Schartl, M., C.-R. Schmidt, A. Anders, and A. Barnekow (1985) Elevated expression of the cellular src gene in tumors of differing ethiologies in Xiphophorus. Int. J. Cancer, 36:199-207.
50. Takahashi, M., T. Iwamoto, and I. Nakashima (1992) Proliferation and neoplastic transformation of pigment cell sin metallothionein/ret transgenic mice. Pigment Cell Res., 5:344-347.
51. Tan, J.C., K. Nocka, P Ray, P. Traktman, and P Besmer (1990) The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science, 247:209-212.
52. Ullrich, A. and J. Schlessinger (1990) Signal transduction by receptors with tyrosine kinase activity. Cell, 61:203-212.
53. Vogelstein, B. and K.W. Kinzler (1993) The multistep nature of cancer. Trends Genet., 9:138-141.
54. Wakamatsu, Y. (1981) Establishment of a cell line from the platyflshswordtail hybrid melanoma. Cancer Res., 41:679-680.
55. Wellbrock, C., R. Lammers, A. Ullrich, and M. Schartl (1995) Association between the melanoma-inducing receptor tyrosine kinase Xmrk and src family tyrosine kinases in Xiphophorus. Oncogene, 10:2135-2143.
56. Wick, S.T., M.M. Dubay, I. Imanil, and L. Brizuela (1995) Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16. Oncogene, 11:2013-2019.
57. Winkler, C., J. Wittbrodt, R. Lammers, A. Ullrich, and M. Schartl (1994) Ligand-dependent tumor induction in medakafish embryos by a Xmrk receptor tyrosine kinase transgene. Oncogene, 9:1517-1525.
58. Wittbrodt, J., D. Adam, B. Malitschek, W. Mäueler, F. Raulf, A. Telling, S.M. Robertson, and M. Schartl (1989) Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature, 341:415-421.
59. Wittbrodt, J., R. Lammers, B. Malitachek, A. Ullrich, and M. Schartl (1992) The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma. EMBO J., 11:4239-4246.
60. Yayon, A., Y.-S. Ma, M. Safran, M. Klagsbrun, and R. Halaban (1996) Suppression of autocrine cell proliferation, survival and tumorigenesis of human melanoma cells and flbroblast growth factor transformed flbroblasts by a Hnase-deficient FGF receptor 1: Evidence for the involvement of src-family kinases. Submitted.