Mushrooms and agaritine: A mini-review

Journal of Functional Foods

Volumn 2, Issue 2, 2010, Pages 91-98

  Roupas, Peter ^a   Keogh, Jennifer ^a   Noakes, Manny ^a   Margetts, Christine ^a   Taylor, Pennie ^a  

^a CSIRO   (Australia)

Author keywords

Agaricus bisporus; Agaritine; Human health; Hydrazine

Indexed keywords

AGARICUS; AGARICUS BISPORUS; BASIDIOMYCOTA; MUS;

EID: 77954862987     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2010.04.003     Document Type: Review

References (57)

1. Andersson, H. C. & Gry, J. (2004). Phenylhydrazines in the cultivated mushroom (Agaricus bisporus) - Occurrence, biological properties, risk assessment and recommendations. TemaNord 558, Nordic Council of Ministers, Copenhagen, Denmark.
2. Andersson H.C., Hajslova J., Schulzova V., Panovska Z., Hajkova L., Gry J. Agaritine content in processed foods containing the cultivated mushroom (Agaricus bisporus) on the Nordic and the Czech market. Food Additives and Contaminants 1999, 16:439-446.
3. Angeli J.P., Ribeiro L.R., Gonzaga M.L., Soares Sde A., Ricardo M.P., Tsuboy M.S., Stidl R., Knasmueller S., Linhares R.E., Mantovani M.S. Protective effects of beta-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes. Cell Biology and Toxicology 2006, 22:285-291.
4. Barbisan L.F., Spinardi-Barbisan A.L., Moreira E.L., Salvadori D.M., Ribeiro L.R., da Eira A.F., de Camargo J.L. Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci. Cancer Science 2003, 94:188-192.
5. Fischer B., Luthy J., Schlatter C. Rapid determination of agaritine in commercial mushrooms (Agaricus bisporus) with high performance liquid chromatography. Zeitschrift fuer Lebensmittel - Untersuchung und Forschung 1984, 179:218-223.
6. Fortes R.C., Novaes M., Recova V.L., Melo A.L. Immunological, hematological, and glycemia effects of dietary supplementation with Agaricus sylvaticus on patients' colorectal cancer. Experimental Biology and Medicine 2009, 234:53-62.
7. Fortes R.C., Recova V.L., Melo A.L., Novaes M.R. Effects of dietary supplementation with medicinal fungus in fasting glycemia levels of patients with colorectal cancer: A randomized, double-blind, placebo-controlled clinical study. Nutrición Hospitalaria: OrganoOficial de la Sociedad Espańola de Nutrición Parenteral y Enteral 2008, 23:591-598.
8. Friederich U., Fischer B., Luthy J., Hann D., Schlatter C., Wurgler F.E. The mutagenic activity of agaritine - A constituent of the cultivated mushroom Agaricus bisporus - And its derivatives detected with the Salmonella/mammalian microsome assay (Ames test). Zeitschrift fuer Lebensmittel - Untersuchung und Forschung 1986, 183:85-89.
9. Garbi Novaes, M., Fortes, R., Recova, V., & Lima, A. (2007a). Biochemical parameters of colorectal cancer patients using diet with Agaricus sylvaticus mushroom: Randomized Study. Annals of Oncology, 18, VII36.
10. Garbi Novaes, M., Fortes, R., Recova, V., & Lima, A. (2007b). Enzymatic biochemistry alterations in colorectal cancer patients using diet with Agaricus sylvaticus mushroom. Annals of Oncology, 18, VII35-VII36.
11. Garbi Novaes, M., Fortes, R., Recova, V., & Lima, A. (2007c). Glycemia levels of colorectal cancer patients using Agaricus sylvaticus mushroom: Placebo-controlled clinical trial. Annals of Oncology, 18, VII36-VII37.
12. Garbi Novaes, M., Fortes, R., Recova, V., & Lima, A. (2007d). Hematological and immunological parameters in colorectal cancer patients after six months of dietary supplementation with Agaricus sylvaticus mushroom. Annals of Oncology, 18, VII36.
13. Garbi Novaes, M., Fortes, R., Recova, V., & Lima, A. (2007e). Quality of life of colorectal cancer patients using diet with Agaricus sylvaticus mushroom after six months treatment. Annals of Oncology, 18, VII37.
14. Gruter A., Friederich U., Wurgler F.E. The mutagenicity of edible mushrooms in a histidine-independent bacterial test system. Food and Chemical Toxicology 1991, 29:159-165.
15. Hajslova J., Hajkova L., Schulzova V., Frandsen H., Gry J., Andersson H.C. Stability of agaritine - A natural toxicant of Agaricus mushrooms. Food Additives and Contaminants 2002, 19:1028-1033.
16. Hashida C., Hayashi K., Jie L., Haga S., Sakurai M., Shimizu H. Quantities of agaritine in mushrooms (Agaricus bisporus) and the carcinogenicity of mushroom methanol extracts on the mouse bladder epithelium. Nippon Koshu Eisei Zasshi 1990, 37:400-405.
17. Hiramoto K., Kaku M., Kato T., Kikugawa K. DNA strand breaking by the carbon-centered radical generated from 4-(hydroxymethyl) benzenediazonium salt, a carcinogen in mushroom Agaricus bisporus. Chemico-Biological Interactions 1995, 94:21-36.
18. Hsu C.H., Hwang K.C., Chiang Y.H., Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. Journal of Alternative Complementary Medicine 2008, 14:299-301.
19. Hsu C.-H., Liao Y.-L., Lin S.-C., Hwang K.-C., Chou P. The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial. Journal of Alternative and Complementary Medicine 2007, 13:97-102.
20. Inuzuka H., Yoshida T. Clinical utility of ABCL (Agaricus Mushroom Extract) treatment for C-type hepatitis. Japanese Pharmacology and Therapeutics 2002, 30:103-107.
21. Kawagishi H., Zhuang C. Compounds for dementia from Hericium erinaceum. Drugs of the Future 2008, 33:149-155.
22. Kim K.C., Kim I.G. Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation. International Journal of Molecular Medicine 1999, 4:273-277.
23. Kondo K., Watanabe A., Akiyama H., Maitani T. The metabolisms of agaritine, a mushroom hydrazine in mice. Food and Chemical Toxicology 2008, 46:854-862.
24. Lee I.P., Kang B.H., Roh J.K., Kim J.R. Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay. Food and Chemical Toxicology 2008, 46:87-95.
25. Matsumoto K., Ito M., Yagyu S., Ogino H., Hirono I. Carcinogenicity examination of Agaricus bisporus, edible mushroom, in rats. Cancer Letters 1991, 58:87-90.
26. Mori K., Inatomi S., Ouchi K., Azumi Y., Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research 2009, 23:367-372.
27. Noguchi M., Kakuma T., Tomiyasu K., Kurita Y., Kukihara H., Konishi F., Kumamoto S., Shimizu K., Kondo R., Matsuoka K. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: A double-blind, placebo-controlled randomized and dose-ranging study. Asian Journal of Andrology 2008, 10:651-658.
28. Papaparaskeva C., Ioannides C., Walker R. Agaritine does not mediate the mutagenicity of the edible mushroom Agaricus bisporus. Mutagenesis 1991, 6:213-217.
29. Papaparaskeva-Petrides C., Ioannides C., Walker R. Contribution of phenolic and quinonoid structures in the mutagenicity of the edible mushroom Agaricus bisporus. Food and Chemical Toxicology 1993, 31:561-567.
30. Park Y.K., Lee H.B., Jeon E.J., Jung H.S., Kang M.H. Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by Comet assay. Biofactors 2004, 21:109-112.
31. Pilegaard K., Kristiansen E., Meyer O.A., Gry J. Failure of the cultivated mushroom (Agaricus bisporus) to induce tumors in the A/J mouse lung tumor model. Cancer Letters 1997, 120:79-85.
32. Pillai T.G., Salvi V.P., Maurya D.K., Nair C.K.K., Janardhanan K.K. Prevention of radiation-induced damages by aqueous extract of Ganoderma lucidum occurring in southern parts of India. Current Science 2006, 91:341-344.
33. Pool-Zobel B.L., Schmezer P., Sinrachatanant Y., Kliagasioglu F., Reinhart K., Martin R., Klein P., Tricker A.R. Mutagenic and genotoxic activities of extracts derived from the cooked and raw edible mushroom Agaricus bisporus. Journal of Cancer Research and Clinical Oncology 1990, 116:475-479.
34. 2-induced oxidative damage to cellular DNA. Teratogenesis Carcinogenesis and Mutagenesis 2002, 22:103-111.
35. Savoie J.-M., Minvielle N., Largeteau M. Radical-scavenging properties of extracts from the white button mushroom, Agaricus bisporus. Journal of the Science of Food and Agriculture 2008, 88:970-975.
36. Schulzova, V., Hajslova, J., Peroutka, R., Hlavasek, J., Gry, J., & Andersson, H.C. (2009). Agaritine content of 53 Agaricus species collected from nature. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment, 26, 82-93.
37. Schulzova V., Hajslova J., Peroutka R., Gry J., Andersson H.C. Influence of storage and household processing on the agaritine content of the cultivated Agaricus mushroom. Food Additives and Contaminants 2002, 19:853-862.
38. Sharman M., Patey A.L., Gilbert J. A survey of the occurrence of agaritine in UK cultivated mushrooms and processed mushroom products. Food Additives and Contaminants 1990, 7:649-656.
39. Shephard S.E., Gunz D., Schlatter C. Genotoxicity of agaritine in the lacI transgenic mouse mutation assay: Evaluation of the health risk of mushroom consumption. Food and Chemical Toxicology 1995, 33:257-264.
40. Shephard S.E., Schlatter C. Covalent binding of agaritine to DNA in vivo. Food and Chemical Toxicology 1998, 36:971-974.
41. Speroni J.J., Beelman R.B., Schisler L.C. Factors influencing the agaritine content in cultivated mushrooms, Agaricus Bisporus. Journal of Food Protection 1983, 46:506-509.
42. Sterner O., Bergman R., Kesler E., Magnusson G., Nilsson L., Wickberg B., Zimerson E., Zetterberg G. Mutagens in larger fungi. I. Forty-eight species screened for mutagenic activity in the Salmonella/microsome assay. Mutation Research 1982, 101:269-281.
43. Stijve T., Pittet A. Absence of agaritine in Pleurotus species and in other cultivated and wild-growing mushrooms not belonging to the genus Agaricus. Deutsche Lebensmittel-Rundschau 2000, 96:251-254.
44. Toth B. Carcinogenesis by N2-[gamma-l(+)-glutamyl]-4-carboxyphenylhydrazine of Agaricus bisporus in mice. Anticancer Research 1986, 6:917-920.
45. Toth B., Erickson J., Gannett P. Lack of carcinogenesis by the baked mushroom Agaricus bisporus in mice: Different feeding regimen. In Vivo 1997, 11:227-231.
46. Toth B., Gannett P. Carcinogenesis study in mice by 3-methylbutanal methylformylhydrazone of Gyromitra esculenta. In Vivo 1990, 4:283-288.
47. Toth B., Nagel D. Studies of the tumorigenic potential of 4-substituted phenylhydrazines by the subcutaneous route. Journal of Toxicology and Environmental Health 1981, 8:1-9.
48. Toth B., Patil K. Carcinogenesis by a single dose of N-methyl-N-formylhydrazine. Journal of Toxicology and Environmental Health 1980, 6:577-584.
49. Toth B., Raha C.R., Wallcave L., Nagel D. Attempted tumor induction with agaritine in mice. Anticancer Research 1981, 1:255-258.
50. Toth B., Sornson H. Lack of carcinogenicity of agaritine by subcutaneous administration in mice. Mycopathologia 1984, 85:75-79.
51. Ukawa Y., Kojima Y., Soma K., Mishima T., Hisamatsu M. Safety evaluation of hot-water extract of Hatake-Shimeji (Lyophyllum decastes Sing.). Journal of the Japanese Society for Food Science and Technology-Nippon Shokuhin Kagaku Kogaku Kaishi 2007, 54:133-137.
52. Wachtel-Galor S., Tomlinson B., Benzie I.F.F. Ganoderma lucidum ('Lingzhi'), a Chinese medicinal mushroom: Biomarker responses in a controlled human supplementation study. British Journal of Nutrition 2004, 91:263-269.
53. Walton K., Coombs M.M., King L.J., Walker R., Ioannides C. Fate of the mushroom hydrazine agaritine in the rat and mouse. Nutrition and Cancer 2000, 37:55-64.
54. Wang L.H., Tsai S.J., Lin S.Y. Aqueous extract from Taiwanese Agrocybe cylindracea strain B protects DNA against center OH-mediated strand breaks. Journal of Food and Drug Analysis 2004, 12:277-285.
55. Yu S., Weaver V., Martin K., Cantorna M.T. The effects of whole mushrooms during inflammation. BMC Immunology 2009, 10:12-25.
56. Zhao L., Zhao G.H., Du M., Zhao Z.D., Xiao L.X., Hu X.S. Effect of selenium on increasing free radical scavenging activities of polysaccharide extracts from a Se-enriched mushroom species of the genus Ganoderma. European Food Research and Technology 2008, 226:499-505.
57. Zhou S., Gao Y., Chan E. Clinical trials for medicinal mushrooms: Experience with Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Lingzhi Mushroom). International Journal of Medicinal Mushrooms 2005, 7:111-117.