Cellular and molecular characterization of ozone-induced pulmonary inflammation in the Cynomolgus monkey

Inflammation

Volumn 33, Issue 3, 2010, Pages 144-156

  Hicks, Alexandra ^a   Kourteva, Galina ^a   Hilton, Holly ^a   Li, Hongli ^a   Lin, Tai An ^a   Liao, Will ^a   Li, Ying ^b   Wei, Xin ^b   March, Thomas ^c   Benson, Janet ^c   Renzetti, Louis M ^a  

^a Roche   (United States)

^b In Silico Sciences   (United States)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Chronic obstructive pulmonary disease; Cynomolgus monkey; Microarray; Ozone; Pulmonary inflammation

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CALGRANULIN A; CD177 ANTIGEN; FK 506 BINDING PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OZONE; PROTEIN ST 2; UNCLASSIFIED DRUG; CYTOKINE; PLASMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; EXPERIMENTAL MONKEY; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MALE; MOLECULAR BIOLOGY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; REPRODUCIBILITY; TISSUE NECROSIS; ANIMAL; BLOOD; BRONCHIOLE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DNA MICROARRAY; GENETICS; MACACA; METABOLISM; PATHOLOGY; PHOTOCHEMICAL SMOG; PNEUMONIA; RESPIRATORY TRACT MUCOSA;

MACACA FASCICULARIS;

ALKALINE PHOSPHATASE; ANIMALS; BLOOD PROTEINS; BRONCHIOLES; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; GENE EXPRESSION PROFILING; MACACA FASCICULARIS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDANTS, PHOTOCHEMICAL; OZONE; PNEUMONIA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA;

EID: 77954724834     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-009-9168-5     Document Type: Article

References (35)

1. MacNee, W., and K. Donaldson. 2000. Exacerbations of COPD: Environmental mechanisms. Chest 117: 390S-379S.
2. Jorres, R.A., O. Holz,W. Zachgo, P. Timm, S. Koschyk, B.Muller, F. Grimminger,W. Seeger, F.J. Kelly, C. Dunster, T. Frischer, G. Lubec, M.Waschewski, A. Niendorf, and H.Magnussen. 2000. The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. American Journal of Respiratory and Critical Care Medicine 161: 1855-1861.
3. Sterner-Kock, A., M. Kock, R. Braun, and D.M. Hyde. 2000. Ozone-induced epithelial injury in the ferret is similar to nonhuman primates. American Journal of Respiratory and Critical Care Medicine 162: 1152-1156.
4. Holz, O., R. Tal-Singer, F. Kanniess, K.J. Simpson, A. Gibson, R. S.J. Vessey, S. Janicki, H. Magnussen, R.A. Jorres, K. Richter, O. Holz, R. Tal-Singer, F. Kanniess, K.J. Simpson, A. Gibson, and R. S.J. Vessey. 2005. Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development. Journal of Clinical Pharmacology 45: 498-503.
5. Seltzer, J., B.G. Bigby, M. Stulbarg, M.J. Holtzman, J.A. Nadel, I.F. Ueki, G.D. Leikauf, E.J. Goetz, and H.A. Boushey. 1986. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. Journal of Applied Physiology 60: 1321-1326.
6. Schelegle, E.S., W.F. Walby, M.F. Alfaro, V.J. Wong, L. Putney, M. Y. Stovall, A. Sterner-Kock, D.M. Hyde, and C.G. Plopper. 2003. Repeated episodes of ozone inhalation attenuates airway injury/ repair and release of substance P, but not adaptation. Toxicology and Applied Pharmacology 186: 127-142.
7. Kanniess, F., S. Khalilieh, A. Ludwig-Sengpiel, P. Stryszak, P. Soni, O. Holz, and H. Magnussen. 2007. SCH 527123, a CXCR2 antagonist, inhibits ozone-induced airway neutrophilia in healthy subjects. European Respiratory Journal 51: 209S.
8. Plopper, C.G., and D.M. Hyde. 2008. The non-human primate as a model for studying COPD and asthma. Pulmonary Pharmacology & Therapeutics 21: 755-766.
9. Hicks, A., J. Benson, T. March, and L. Renzetti. 2007. Ozone inhalation produces reproducible lung inflammation in the Cynomolgus monkey. European Respiratory Journal 51: 134S.
10. Kourteva, G., H. Hilton, X. Wei, Y.L. Li, T. March, J. Benson, J.A. Rosinski, and A. Hicks. 2008. Lung and blood gene expression profiles from Cynomolgus monkeys exposed to ozone. FASEB Journal 22: lb212.
11. Gentleman, R., V.J. Carey, and W. Huber. 2005. Bioinformatics and computational biology solutions using R and bioconductor. (Statistics for Biology and Health). Springer.
12. Krishna, M.T., J. Madden, L.M. Teran, G.L. Biscione, L.C.K. Lau, N.J. Withers, T. Sandstrom, I. Mudway, F.J. Kelly, A. Walls, A.J. Frew, and S.T. Holgate. 1998. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. European Respiratory Journal 11: 1294-1300.
13. Kooter, I.M., J.L.A. Pennings, P.H.B. Fokkens, D.L.A.C. Leseman, A.J.F. Boere, M.E. Gerlofs-Nijland, F.R. Cassee, J.A.C. Schalk, T. J.H. Orzechowski, M.M. Schaap, T.M. Breit, J.A.M.A. Dormans, C.T.M. van Oostrom, A. de Vries, and H. van Steeg. 2007. Ozone induces clear cellular and molecular responses in the mouse lung independently of the transcription-coupled repair status. Journal of Applied Physiology 102: 1185-1192.
14. Chang, M.M., R. Wu, C.G. Plopper, and D.M. Hyde. 1998. IL-8 is one of the major chemokines produced by monkey airway epithelium after ozone-induced injury. American Journal of Physiology 275: L524-L532.
15. Johnston, R.A., J.P. Mizgerd, and S.A. Shore. 2005. CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure. American Journal of Physiology. Lung Cellular and Molecular Physiology 288: L61-L67.
16. Yu, M., X. Zheng, H. Witschi, and K.E. Pinkerton. 2002. The role of interleukin 6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants. Tox Sci 68: 488-497.
17. Kierstein, S., F.R. Poulain, Y. Cao, M. Grous, R. Mathias, G. Kierstein, M.F. Beers, M. Salmon, R.A. Panettieri Jr., and A. Haczku. 2006. Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D. Respiratory Research 7: 85-94.
18. Kierstein, S., K. Krytska, S. Sharma, Y. Amrani, M. Salmon, R.A. Panettieri Jr., J. Zangrilli, and A. Haczku. 2008. Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice. Allergy 63: 438-446.
19. Potter-Perigo, S., E.D. Kaplan, D.L. Luchtel, C. Baker, L.C. Altman, and T.N. Wight. 1998. Ozone alters the expression of tenascin-C in cultured primate nasal epithelial cells. American Journal of Respiratory Cell and Molecular Biology 18: 471-478.
20. Hoshino, M., S. Morita, H. Iwashita, Y. Sagiya, T. Nagi, A. Nakanishi, Y. Ashida, O. Nishimura, Y. Fujisawa, and M. Fujino. 2002. Increased expression of the human Ca2+-activates Cl- channel 1 (CaCC1) gene in the asthmatic airway. American Journal of Respiratory and Critical Care Medicine 165(8): 1132-1138.
21. Hauber, H.P., C. Bergeron, A. Tsicopoulos, B. Wallaert, R. Olivenstein, K.J. Holroyd, R.C. Levitt, and Q. Hamid. 2005. Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis. Canadian Respiratory Journal 12(3): 143-146.
22. Williams, A.S., R. Issa, S.Y. Leung, P. Nath, G.D. Ferguson, B.L. Bennett, I.M. Adcock, and K.F. Chung. 2007. Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-jun NH2 terminal kinase inhibitor SP600125. Journal of Pharmacology and Experimental Therapeutics 322: 351-359.
23. Lim, S.Y., M. Raftery, H. Cai, K. Hsu, W.X. Yan, H.L. Hseih, R.N. Watts, D. Richardson, S. Thomas, M. Perry, and C.L. Geczy. 2008. S-Nitrosylated S100A8: Novel anti-inflammatory properties. Journal of Immunology 181: 5627-5636.
24. Arend, W.P., G. Palmer, and C. Gabay. 2008. IL-1, IL-18, and IL- 33 families of cytokines. Immunological Reviews 223: 20-38.
25. Sunhil, V.R., K.J. Patel, M. Nilsen-Hamilton, D.E. Heck, J.D. Laskin, and D.L. Laskin. 2007. Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Experimental and Molecular Pathology 83: 177-187.
26. Andre, E., T. Stoeger, S. Takenaka, M. Bahnweg, B. Ritter, E. Karg, B. Lentner, C. Reinhard, H. Schulz, and M. Wjst. 2006. Inhalation of ultrafine carbon particles triggers biphasic proinflammatory response in the mouse lung. European Respiratory Journal 28: 275-285.
27. Keatings, V.M., and P.J. Barnes. 1997. Granulocyte activation markers in induced sputum: Comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. American Journal of Respiratory and Critical Care Medicine 155(2): 449-453.
28. Sachs, U.J.H., C.L. Andrei-Selmer, A. Maniar, T. Weiss, C. Paddock, V.V. Orlova, E.Y. Choi, P.J. Newman, K.T. Preissner, T. Chavakis, and S. Santoso. 2007. The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). Journal of Biological Chemistry 282(32): 23603-23612.
29. Sun, J., and K.F. Chung. 1997. Airway inflammation despite loss of bronchial hyperresponsiveness after multiple ozone exposures. Respiratory Medicine 91: 47-55.
30. van Bree, L., J.A.M.A. Dormans, H.S. Koren, R.B. Devlin, and P.J. A. Rombout. 2002. Attenuation and recovery of pulmonary injury in rats following short-term, repeated daily exposure to ozone. Inhalation Toxicology 14: 883-900.
31. Tepper, J.S., D.L. Costa, J.R. Lehmann, M.F. Weber, and G.E. Hatch. 1989. Unattenuated structural and biochemical alterations in the rat lung during functional adaptation to ozone. American Review of Respiratory Disease 140: 493-501.
32. Devlin, R.B., L.J. Folinsbee, F. Biscardi, G. Hatch, S. Becker, M. C. Madden, M. Robbins, and S.H. Koren. 1997. Inflammation and cell damage induced by repeated exposure of humans to ozone. Inhalation Toxicology 9: 211-235.
33. Barnes, P.J., B. Chowdhury, S.A. Kharitonov, H. Magnussen, C.P. Page, D. Postma, and M. Saetta. 2006. Pulmonary biomarkers in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 174: 6-14.
34. Wang, I.M., S. Stepaniants, Y. Boie, J.R. Mortimer, B. Kennedy, M. Elliott, S. Hayashi, L. Loy, S. Coulter, S. Cervino, J. Harris, M. Thornton, R. Raubertas, C. Roberts, J.C. Hogg, M. Crackower, G. O'Neill, and P.D. Paré. 2008. Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer. American Journal of Respiratory and Critical Care Medicine 177: 402-411.
35. Di Stefano, A., G. Caramori, F.L. Ricciardolo, A. Capelli, I.M. Adcock, and C.F. Donner. 2004. Cellular and molecular mechanisms in chronic obstructive pulmonary disease: An overview. Clinical and Experimental Allergy 34: 1156-1167.