Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis

Canadian Respiratory Journal

Volumn 12, Issue 3, 2005, Pages 143-146

  Hauber, Hans Peter ^a   Bergeron, Celine ^a   Tsicopoulos, Anne ^b   Wallaert, Benoit ^b   Olivenstein, Ron ^a   Holroyd, Kenneth J ^c   Levitt, Roy C ^c   Hamid, Qutayba ^a  

^a MCGILL UNIVERSITY   (Canada)

^b INSTITUT PASTEUR DE LILLE   (France)

^c Genaera Corporation   (United States)

Author keywords

Chronic bronchitis; COPD; hCLCA1; Interleukin 9; Mucus

Indexed keywords

CHLORIDE CHANNEL; INTERLEUKIN 9; INTERLEUKIN 9 RECEPTOR; MESSENGER RNA; MUCIN;

ADULT; AGED; ARTICLE; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CALCIUM ACTIVATED CHLORIDE CHANNEL; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBMUCOSA;

EID: 20044376139     PISSN: 11982241     EISSN: None     Source Type: Journal    
DOI: 10.1155/2005/531432     Document Type: Article

References (13)

1. Senior RM, Shapiro SD. Chronic obstructive pulmonary disease: Epidemiology, pathophysiology, and pathogenesis. In: Fishman AP, ed. Fishman's Pulmonary Diseases and Disorders. McGraw-Hill, New York, 1998;659-81.
2. Louahed J, Toda M, Jen J, et al. Interleukin-9 upregulates mucus expression in the airways. Am J Respir Cell Mol Biol 2000;22:649-56.
3. Zhou Y, Dong Q, Louahed J, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 2001;25:486-91.
4. Nakanishi A, Morita S, Iwashita H, et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA 2001;98:5175-80.
5. Toda M, Tulic MK, Levitt RC, Hamid Q. A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. J Allergy Clin Immunol 2002;109:246-50.
6. Hauber HP, Manoukian JJ, Nguyen LH, et al. Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis. Laryngoscope 2003;113:1037-42.
7. Panzner P, Lafitte JJ, Tsicopoulos A, Hamid Q, Tulic MK. Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest 2003;124:1909-15.
8. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis 1987;136:225-44.
9. Giaid A, Michel RF, Stewart DJ, Sheppard M, Corrin B, Hamid Q. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Lancet 1993;341:1550-4.
10. Hamid Q, Azzawi M, Ying S, et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991;87:1541-6.
11. Hamid Q, Wharton J, Terenghi G, et al. Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage. Proc Natl Acad Sci USA 1987;84:6760-4.
12. Kim KC, Wasano K, Niles RM, Schuster JE, Stone PJ, Brody JS. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc Natl Acad Sci USA 1987;84:9304-8.
13. Li JD, Dohrman AF, Gallup M, et al. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci USA 1997;94:967-72.