Inflammation and cell damage induced by repeated exposure of humans to ozone

Inhalation Toxicology

Volumn 9, Issue 3, 1997, Pages 211-235

  Devlin, Robert B ^a   Folinsbee, Lawrence J ^b   Biscardi, Frank ^a   Hatch, Gary ^a   Becker, Susanne ^a   Madden, Michael C ^b   Robbins, Mark ^a   Koren, Hillel S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030981294     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/089583797198222     Document Type: Article

References (41)

1. Anderson, M. E. 1985. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113:548-555.
2. Brummer, M. E. G., Schwartz, L. W., and McQuillen, N. K. 1977. A quantitative study to lung damage by scanning electron microscopy: Inflammatory cell response to high-ambient levels of ozone. Scan. Electron Microsc. 2:513-518.
3. Bui, M. H., Sauty, A., Collet, F., and Leuenberger, P. 1992. Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers.J. Nutr. 122:312-316.
4. Calderon-Carciduenas, L, Osorno-Velazquez, A., Bravo-Alvarez, H., Delgado-Chavez, R., and Barrios-Marquez, R. 1992. Histopathologic changes of the nasal mucosa in southwest Metropolitan Mexico City inhabitants. Am. J. Pathol. 140:225-232.
5. Chatham, M. D., Eppler, J. H., Jr., Sauder, L. R., Green, D., and Kulle, T. J. 1987. Evaluation of the effects of vitamin C on ozone-induced bronchoconstriction in normal subjects. Ann. NYAcad. Sci. 498:269-279.
6. Detels, R., Rokaw, S. N., Coulson, A. H., Tashkin, D. P., Sayre, J. W., and Massey, F. J., Jr. 1979. The UCLA population studies of chronic obstructive respiratory disease. Part I, Methodology and comparison of lung function in areas of high and low pollution. Am. J. Epidemiol. 109:33-58.
7. Dctels, R., Sayre, J. W., Coulson, A. H., Rokaw, S. N., Massey, F. J., Tashkin, D. P., and Wu, M. 1981. The UCLA population studies of chronic obstructive respiratory disease. Part 4, Respiratory effect of long-term exposure to photochemical oxidants, nitrogen dioxide, and sulfates on current and never smokers. Am. Rev. Respir. Dis. 124:673-680.
8. Devlin, R. B., McDonnell, W. F., Mann, R., Becker, S., House, D. E., Schreinemachers, D., and Koren, H. S. 1991. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am. J. Respir. Cell Mol. Biol. 4:72-81.
9. Devlin, R. B., McDonnell, W. F., Becker, S., Madden, M., McGee, M. P., Perez, R., Hatch, G., House, D. E., and Koren, H. S. 1996. Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for two hours: A comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hours after exposure. Toxicol. Appl. Pharmacol. 138:176-185.
10. Evans, M. J., Dekker, N. P., Cabral-Anderson, L. J., and Shami, S. C. 1985. Morphological basis of tolerance to ozone. Exp. Mol. Pathol. 42:366-376.
11. Folinsbee, L. J., Bedi, J. F., and Horvath, S. M. 1980. Respiratory responses in humans repeatedly exposed to low concentrations of ozone. Am. Rev. Respir. Dis. 121:431-439.
12. Folinsbee, L. J., Horstman, D. H., Kehrl, H. R., Harder, S., Abdul-Salaam, S., and Ives, P. J. 1994. Respiratory responses to repeated prolonged exposure to 0.12 ppm ozone. Am. J. Resp. Crit. Care Med 149:98-105.
13. Foxcroft, W. J., and Adams, W. C. 1986. Effects of ozone exposure on four consecutive days on work performance and VO2max. J. Appl. Physiol. 61:960-966.
14. Gimbrone, M. A., Jr., Obin, M. S., Brock, A. F., Luis, E. A., Hass, P. E., Hebert, C. A., Yip, Y. K., Leung, D. W., Lowe, D. G., Kohr, W. J. 1989. Endothelial interleukin-8: A novel inhibitor of leukocyte-endothelial interactions. Science 246:1601-1603.
15. Hackney, J. D., Linn, W. S., Mohler, J. G., and Collier, C. R. 1977. Adaptation to short-term respiratory effects of ozone in men exposed repeatedly. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 43:82-85.
16. Harkema, J. R., and Hotchkiss, J. A. 1993. Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: Novel animal models to study toxicant-induced epithelial transformation in airways. Toxicol. Lett. 68:251-263.
17. Hatch, G. E., Slade, R., Harris, L. P., McDonnell, W. F., Devlin, R. B., Koren, H. S., Costa, D. L., and McKee, J. 1994. Ozone dose and effect in humans and rats. Am. ]. Resp. Crit. Care Med. 150:676-683.
18. Horvath, S. M., Gliner, J. A., and Folinsbee, L. J. 1981. Adaptation to ozone: Duration of effect. Am. Rev. Respir. Dis. 123:496-499.
19. Kinney, P. L., Nilsen, D. M., Lippmann, M., Brescia, M., Gordon, T., McGovern, T., El-Fawal, H., Devlin, R. B., and Rom, W. N. 1996. Biomarkers of lung inflammation in recreational joggers exposed to ozone. Am. Rev. Respir. Dis., in press.
20. Kodavanti, U. P., Hatch, G. E., Starcher, B., Giri, S. N., Winselt, D., and Costa, D. L. 1995. Ozone induced pulmonary functional, pathological, and biochemical changes in normal and vitamin C-deficient guinea pigs. Fundam. Appl. Toxicol. 24:154-164.
21. Koren, H. S., Devlin, R. B., Graham, D. E., Mann, R., McGee, M. P., Horstman, D. H., Kozumbo, W. J., Becker, S., House, D. E., McDonnell, W. F., and Bromberg, P. A. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139:407-415.
22. Kutnink, M. A., Hawkes, W. C., Schaus, E. E., and Omaye, S. T. 1987. An internal standard method for the unattended high-performance liquid chromatographic analysis of ascorbic acid in blood components. Anal. Biochem. 166:424-430.
23. Ley, K., Baker, J. B., Cybulsky, M. I., Gimbrone, M. A., Jr., and Luscinskas, F. W. 1993. Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J. Immunol. 151:6347-6357.
24. Linn, W. S., Medway, D. A., Anzar, U. T., Valencia, L. M., Spier, C. E., Tsao, F. S., Fischer, D. A., and Hackney, J. D. 1982. Persistence of adaptation to ozone in volunteers exposed repeatedly for six weeks. Am. Rev. Respir. Dis. 125:491-495.
25. Linn, W. S., Avol, E. L, Shamoo, D. A., Peng, R. C, Valencia, L. M., Little, D. E., and Hackney, J. D. 1988. Repeated laboratory ozone exposures of volunteer Los Angeles residents: An apparent seasonal variation in response. Toxicol. Indust. Health 4:505-520.
26. Matthay, M. A., Eschenbacher, W. L., and Goetzl, E. J. 1984. Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. J. Clin. Immunol. 4:479-483.
27. Nikula, K. J., Wilson, D. W., Dungworth, D. L., and Plopper, C. G. 1988a. In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea. Toxicol. Appl. Pharmacol. 93:394-402.
28. Nikula, K. J., Wilson, D. W., Giri, S. N., Plopper, C. G., and Dungworth, D. L. 1988b. The response of the rat trachéal epithelium to ozone exposure. Am. J. Pathol. 131:373-384.
29. Pacht, E. R., Kaseki, H., Mohammed, J. R., Cornwell, D. G., and Davis, W. B. 1986. Deficiency of vitamin E in the alveolar fluid of cigarette smokers. J. Clin. Invest. 77:789-796.
30. Pick, E., and Keisari, Y. 1981. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages-Induction by multiple nonphagocytic stimuli. Cell. Immunol. 59:301-318.
31. Plopper, C. G., Chu, F. P., Haselton, C. J., Peake, J., Wu, J., and Pinkerton, K. E. 1994. Dose dependent tolerance to ozone. Am. J. Pathol. 144:404-420.
32. Schwanz, L. W., Dungworth, D. L., Mustafa, M. G., Tarkington, B. K., and Tyler, W. S. 1976. Pulmonary responses of rats to ambient levels of ozone: effects of 7-day intermittent or continuous exposure. Lab. Invest. 34:565-578.
33. Seltzer, J., Bigby, B. G., Stulbarg, M., Holtzman, M. J., Nadel, J. A., Ueki, l. F., Leikauf, G. D., Goetzl, E. J., and Boushey, H. A. 1986. Gyinduced change in bronchial reactivity to methacholine and airway inflammation in humans.J. Appl. Physiol. 60:1321-1326.
34. Slade, R., Highfill, J. W., and Hatch, G. E. 1989. Effects of depletion of ascorbic acid or nonprotein sulfhydryls on the acute inhalation toxicity of nitrogen dioxide, ozone, and phogene. Inhal. Toxicol. 1:261-271.
35. Slade, R., Crissman, K., Norwood, J., and Hatch, G. 1993. Comparison of antioxidant substances in bronchoalveolar lavage cells and fluid from humans, guinea pigs, and rats. Exp. Lung Res. 19:469-484.
36. Stevens, R. J., Sloan, M. F., Evans, M. J., and Freeman, G. 1974. Alveolar type 1 cell response to exposure to 0.5 ppm ozone for short periods, Exp. Mol. Pathol. 20:11-23.
37. Tepper, J. S., Costa, D. L., Lehmann, J. R., Weber, M. F., and Hatch, G. E. 1989. Unattenuated structural and biochemical alterations in the rat lung during functional adaptation to ozone. Am. Rev. Respir. Dis. 140:493-501.
38. van Bree, L., Koren, H. S., Devlin, R. B., and Rombout, P. J. A. 1993. Recovery from attentuated inflammation in lower airways of rats following repeated exposure to ozone. Am. Rev. Respir. Dis. 147:A633.
39. Vandewoude, M., Claeys, M., and De Leeuw, I. 1984. Determination of alpha-tocopherol in human plasma by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. 311:176-182.
40. Warren, D. L., Guth, D. J., and Last, J. A. 1986. Synergistic interaction of ozone and respirable aerosols oh rat lungs. Toxicol. Appl. Pharmacol. 84:470-479.
41. Zwick, H., Popp, W., Wagner, C., Reiser, K., Schmoger, J., Bock, A., Herkner, K., and Radunsky, K. 1991. Effects of ozone on the respiratory health, allergic sensitization, and cellular immune system in children [published erratum appears \n Am Rev. Respir. Dis. 1992]. Am. Rev. Respir. Dis. 144:1075-1079.