Complement regulator-acquiring surface protein 1 of borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen

Journal of Infectious Diseases

Volumn 202, Issue 3, 2010, Pages 490-498

  Hallström, Teresia ^a   Haupt, Katrin ^a   Kraiczy, Peter ^d   Hortschansky, Peter ^b   Wallich, Reinhard ^e   Skerka, Christine ^a   Zipfel, Peter F ^a,c  

^a Departments of Infection Biology   (Germany)

^b Leibniz Institute for Natural Product Research and Infection Biology   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENIC PROTEIN 2; CHROMOGENIC SUBSTRATE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COMPLEMENT REGULATOR ACQUIRING SURFACE PROTEIN 1; FIBRINOGEN; FIBRONECTIN; LAMININ; MEMBRANE PROTEIN; PLASMIN; PLASMINOGEN; PROUROKINASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; COMPLEMENT REGULATOR ACQUIRING SURFACE PROTEINS, BORRELIA BURGDORFERI; COMPLEMENT REGULATOR-ACQUIRING SURFACE PROTEINS, BORRELIA BURGDORFERI; SCLEROPROTEIN; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; BACTERIUM CULTURE; BINDING SITE; BORRELIA BURGDORFERI; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRINOGEN METABOLISM; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; FLUORESCENT ANTIBODY TECHNIQUE; HOST PATHOGEN INTERACTION; HUMAN; METABOLISM; PATHOGENICITY; PROTEIN ANALYSIS; PROTEIN DOMAIN;

BACTERIAL PROTEINS; BONE MORPHOGENETIC PROTEIN 2; BORRELIA BURGDORFERI; EXTRACELLULAR MATRIX PROTEINS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE PROTEINS; PLASMINOGEN; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; SURFACE PLASMON RESONANCE; VIRULENCE FACTORS;

EID: 77954716988     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/653825     Document Type: Article

References (43)

1. Hytonen J, Hartiala P, Oksi J, Viljanen MK. Borreliosis: recent research, diagnosis, and management. Scand J Rheumatol 2008; 37:161-172.
2. Hildenbrand P, Craven DE, Jones R, Nemeskal P. Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis. AJNR Am J Neuroradiol 2009; 30:1079-1087.
3. Lelovas P, Dontas I, Bassiakou E, Xanthos T. Cardiac implications of Lyme disease, diagnosis and therapeutic approach. Int J Cardiol 2008; 129:15-21.
4. Puius YA, Kalish RA. Lyme arthritis: pathogenesis, clinical presentation, and management. Infect Dis Clin North Am 2008; 22:289-300.
5. Coburn J, Fischer JR, Leong JM. Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. Mol Microbiol 2005; 57:1182-1195.
6. Ebara S, Nakayama K. Mechanism for the action of bone morphogenetic proteins and regulation of their activity. Spine 2002; 27:S10-S15.
7. Hogan BL. Bone morphogenetic proteins in development. Curr Opin Genet Dev 1996; 6:432-438.
8. Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 1996; 10:1580-1594.
9. Bergmann S, Lang A, Rohde M, et al. Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. J Cell Sci 2009; 122:256-267.
10. Hallstrom T, Trajkovska E, Forsgren A, Riesbeck K. Haemophilus influenzae surface fibrils contribute to serum resistance by interacting with vitronectin. J Immunol 2006; 177:430-436.
11. Tan TT, Forsgren A, Riesbeck K. The respiratory pathogen Moraxella catarrhalis binds to laminin via ubiquitous surface proteins A1 and A2. J Infect Dis 2006; 194:493-497.
12. Tan TT, Nordstrom T, Forsgren A, Riesbeck K. The respiratory pathogen Moraxella catarrhalis adheres to epithelial cells by interacting with fibronectin through ubiquitous surface proteins A1 and A2. J Infect Dis 2005; 192:1029-1038.
13. Travis J, Potempa J, Maeda H. Are bacterial proteinases pathogenic factors? Trends Microbiol 1995; 3:405-407.
14. Attali C, Frolet C, Durmort C, Offant J, Vernet T, Di Guilmi AM. Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix. Infect Immun 2008; 76:466-476.
15. Sanderson-Smith ML, Dinkla K, Cole JN, et al. M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate. FASEB J 2008; 22:2715-2722.
16. Bergmann S, Hammerschmidt S. Fibrinolysis and host response in bacterial infections. Thromb Haemost 2007; 98:512-520.
17. Antikainen J, Kuparinen V, Lahteenmaki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol 2007; 51:526-534.
18. Kunert A, Losse J, Gruszin C, et al. Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein. J Immunol 2007; 179:2979-2988.
19. Poltermann S, Kunert A, von der Heide M, Eck R, Hartmann A, Zipfel PF. Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans. J Biol Chem 2007; 282:37537-37544.
20. Bergmann S, Rohde M, Chhatwal GS, Hammerschmidt S. a-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Mol Microbiol 2001; 40:1273-1287.
21. Fuchs H, Wallich R, Simon MM, Kramer MD. The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor. Proc Natl Acad Sci U S A 1994; 91:12594-12598.
22. Luo S, Poltermann S, Kunert A, Rupp S, Zipfel PF. Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a factor H, FHL-1 and plasminogen binding surface protein. Mol Immunol 2009; 47:541-550.
23. Ringdahl U, Sjobring U. Analysis of plasminogen-binding M proteins of Streptococcus pyogenes. Methods 2000; 21:143-150.
24. Bykowski T, Woodman ME, Cooley AE, et al. Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the Lyme disease spirochete's mammal-tick infection cycle. Infect Immun 2007; 75:4227-4236.
25. Haupt K, Kraiczy P, Wallich R, Brade V, Skerka C, Zipfel PF. Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins. J Infect Dis 2007; 196:124-133.
26. Haupt K, Kraiczy P, Wallich R, Brade V, Skerka C, Zipfel PF. FHR-1, an additional human plasma protein, binds to complement regulatoracquiring surface proteins of Borrelia burgdorferi. Int J Med Microbiol 2008; 298:287-291.
27. Kraiczy P, Skerka C, Kirschfink M, Brade V, Zipfel PF. Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and factor H. Eur J Immunol 2001; 31:1674-1684.
28. Brissette CA, Haupt K, Barthel D, et al. Borrelia burgdorferi infectionassociated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. Infect Immun 2009; 77:300-306.
29. Kraiczy P, Skerka C, Brade V, Zipfel PF. Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi. Infect Immun 2001; 69:7800-7809.
30. Kraiczy P, Hellwage J, Skerka C, et al. Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins. J Biol Chem 2004; 279: 2421-2429.
31. Kraiczy P, Hellwage J, Skerka C, et al. Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family. Eur J Immunol 2003; 33:697-707.
32. Prodinger WM, Hellwage J, Spruth M, Dierich MP, Zipfel PF. The Cterminus of factor H: monoclonal antibodies inhibit heparin binding and identify epitopes common to factor H and factor H-related proteins. Biochem J 1998; 331(Pt 1):41-47.
33. Wieland GD, Nehmann N, Muller D, et al. Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65. J Cell Sci 2005; 118:3203-3212.
34. Namiki M, Akiyama S, Katagiri T, et al. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. J Biol Chem 1997; 272:22046-22052.
35. Rossmann E, Kraiczy P, Herzberger P, et al. Dual binding specificity of a Borrelia hermsii-associated complement regulator-acquiring surface protein for factor H and plasminogen discloses a putative virulence factor of relapsing fever spirochetes. J Immunol 2007; 178:7292-7301.
36. Alitalo A, Meri T, Ramo L, et al. Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation. Infect Immun 2001; 69:3685-3691.
37. Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, Chaconas G. Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog 2008; 4:e1000090.
38. Coleman JL, Roemer EJ, Benach JL. Plasmin-coated Borrelia burgdorferi degrades soluble and insoluble components of the mammalian extracellular matrix. Infect Immun 1999; 67:3929-3936.
39. Coleman JL, Sellati TJ, Testa JE, Kew RR, Furie MB, Benach JL. Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers. Infect Immun 1995; 63:2478-2484.
40. Lagal V, Portnoi D, Faure G, Postic D, Baranton G. Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity. Microbes Infect 2006; 8:645-652.
41. Lahteenmaki K, Kuusela P, Korhonen TK. Bacterial plasminogen activators and receptors. FEMS Microbiol Rev 2001; 25:531-552.
42. Coleman JL, Benach JL. Use of the plasminogen activation system by microorganisms. J Lab Clin Med 1999; 134:567-576.
43. Coleman JL, Gebbia JA, Piesman J, Degen JL, Bugge TH, Benach JL. Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell 1997; 89: 1111-1119.