The respiratory pathogen Moraxella catarrhalis binds to laminin via ubiquitous surface proteins A1 and A2

Journal of Infectious Diseases

Volumn 194, Issue 4, 2006, Pages 493-497

  Tan, Thuan Tong ^a,b   Forsgren, Arne ^a   Riesbeck, Kristian ^a  

^a LUND UNIVERSITY   (Sweden)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

LAMININ; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; UBIQUITOUS SURFACE PROTEIN A1; UBIQUITOUS SURFACE PROTEIN A2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIUM ADHERENCE; BINDING AFFINITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE EXACERBATION; GENE MUTATION; LOWER RESPIRATORY TRACT INFECTION; MORAXELLA CATARRHALIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SMOKING HABIT; STRAIN IDENTIFICATION;

BACTERIAL ADHESION; BACTERIAL OUTER MEMBRANE PROTEINS; HUMANS; LAMININ; MORAXELLA (BRANHAMELLA) CATARRHALIS; MORAXELLACEAE INFECTIONS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 33746685653     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/505581     Document Type: Article

References (15)

1. Karalus R, Campagnari A. Moraxella catarrhalis: a review of an important human mucosal pathogen. Microbes Infect 2000; 2:547-59.
2. McMichael JC, Fiske MJ, Fredenburg RA, et al. Isolation and characterization of two proteins from Moraxella catarrhalis that bear a common epitope. Infect Immun 1998;66:4374-81.
3. Lafontaine ER, Cope LD, Aebi C, Latimer JL, McCracken GH Jr, Hansen EJ. The UspA1 protein and a second type of UspA2 protein mediate adherence of Moraxella catarrhalis to human epithelial cells in vitro. J Bacteriol 2000; 182:1364-73.
4. Tan TT, Nordstrom T, Forsgren A, Riesbeck K. The respiratory pathogen Moraxella catarrhalis adheres to epithelial cells by interacting with fibronectin through ubiquitous surface proteins A1 and A2. J Infect Dis 2005; 192:1029-38.
5. Hill DJ, Edwards AM, Rowe HA, Virji M. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM)-binding recombinant polypeptide confers protection against infection by respiratory and urogenital pathogens. Mol Microbiol 2005; 55:1515-27.
6. Aebi C, Lafontaine ER, Cope LD, et al. Phenotypic effect of isogenic uspA1 and uspA2 mutations on Moraxella catarrhalis 035E. Infect Immun 1998; 66:3113-9.
7. Nordstrom T, Blom AM, Forsgren A, Riesbeck K. The emerging pathogen Moraxella catarrhalis interacts with complement inhibitor C4b binding protein through ubiquitous surface proteins A1 and A2. J Immunol 2004; 173:4598-606.
8. Attia AS, Lafontaine ER, Latimer JL, Aebi C, Syrogiannopoulos GA, Hansen EJ. The UspA2 protein of Moraxella catarrhalis is directly involved in the expression of serum resistance. Infect Immun 2005; 73: 2400-10.
9. Nordstrom T, Blom AM, Tan TT, Forsgren A, Riesbeck K. Ionic binding of C3 to the human pathogen Moraxella catarrhalis is a unique mechanism for combating innate immunity. J Immunol 2005; 175:3628-36.
10. Murphy TF, Brauer AL, Aebi C, Sethi S. Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease. Infect Immun 2005; 73:3471-8.
11. Amin K, Ekberg-Jansson A, Lofdahl CG, Venge P. Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study. Thorax 2003; 58:135-42.
12. Forsgren A, Brant M, Karamehmedovic M, Riesbeck K. The immunoglobulin D-binding protein MID from Moraxella catarrhalis is also an adhesin. Infect Immun 2003; 71:3302-9.
13. Fink DL, Green BA, St. Geme JW 3rd. The Haemophilus influenzae Hap autotransporter binds to fibronectin, laminin, and collagen IV. Infect Immun 2002; 70:4902-7.
14. Hoiczyk E, Roggenkamp A, Reichenbecher M, Lupas A, Heesemann J. Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins. EMBO J 2000; 19:5989-99.
15. Aebi C, Maciver I, Latimer JL, et al. A protective epitope of Moraxella catarrhalis is encoded by two different genes. Infect Immun 1997; 65: 4367-77.