Rapid optimization of antibotulinum toxin antibody fragment production by an integral approach utilizing RC-SELDI mass spectrometry and statistical design

Biotechnology Progress

Volumn 22, Issue 1, 2006, Pages 233-240

  Park, Jun T ^a   Bradbury, Lisa ^b   Kragl, Frank J ^c   Lukens, Dennis C ^a   Valdes, James J ^a  

^a EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

^b CIPHERGEN BIOSYSTEMS INC   (United States)

^c SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; DESORPTION; IONIZATION; MASS SPECTROMETRY; TOXIC MATERIALS;

ANTIBOTULINUM TOXIN ANTIBODY; FERMENTATION PROCESS; IMMUNO-AFFINITY HPLC ASSAY; MAXIMAL BT-FAB ANTIBODY PRODUCTION;

ANTIBODIES;

BOTULINUM TOXIN; IMMUNOGLOBULIN F(AB) FRAGMENT;

BIOSYNTHESIS; CONFERENCE PAPER; CULTURE MEDIUM; ESCHERICHIA COLI; FERMENTATION; HEAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MICROBIOLOGY; STATISTICS; TIME;

BOTULINUM TOXINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; ESCHERICHIA COLI; FERMENTATION; HEAT; IMMUNOGLOBULIN FAB FRAGMENTS; INDUSTRIAL MICROBIOLOGY; RESEARCH DESIGN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

ESCHERICHIA COLI;

EID: 32344449437     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp050158t     Document Type: Conference Paper

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