Elimination of HIV-1 infection by treatment with a doxorubicin-conjugated anti-envelope antibody

AIDS

Volumn 20, Issue 15, 2006, Pages 1911-1915

  Johansson, Susanne ^a,e   Goldenberg, David M ^b,c   Griffiths, Gary L ^c   Wahren, Britta ^a   Hinkula, Jorma ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

^c IMMUNOMEDICS INC   (United States)

^d LINKÖPING UNIVERSITY   (Sweden)

^e SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

Doxorubicin; HIV 1; Immunoconjugates; Mice; Monoclonal antibodies; Passive immunization

Indexed keywords

ANTIBODY CONJUGATE; DOXORUBICIN; GAG PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD74; MONOCLONAL ANTIBODY LL1; MONOCLONAL ANTIBODY P4 D10; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS NEUTRALIZATION; VIRUS REPLICATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFECTIVE AGENTS; CELL LINE; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; IMMUNIZATION, PASSIVE; IMMUNOCONJUGATES; JURKAT CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; NEUTRALIZATION TESTS; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 33748906061     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aids.0000247111.58961.60     Document Type: Article

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