Why the Brugada syndrome is not yet a disease: Syndromes, diseases, and genetic causality

Cardiovascular Research

Volumn 72, Issue 3, 2006, Pages 361-363

  Coronel, Ruben ^a   Berecki, Géza ^a   Opthof, Tobias ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BRUGADA SYNDROME; DNA SEQUENCE; EDITORIAL; GENE MUTATION; GENETIC SCREENING; HEART ARRHYTHMIA; HEART FAILURE; HEREDITY; HUMAN; LONG QT SYNDROME; MEDICAL RESEARCH; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; ST SEGMENT ELEVATION;

BRUGADA SYNDROME; HUMANS; LONG QT SYNDROME; MUTATION; MYOCARDIUM; SODIUM CHANNELS;

EID: 33750532715     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.09.004     Document Type: Editorial

References (18)

1. Coronel R., van Lieshout J.J., and de Groot J.R. Defining heart failure. Cardiovasc Res 50-53 (2001) 419-422
2. Koopmann T.T., Alders M., Jongbloed R.J., Guerrero S., Mannens M.M.A.M., Wilde A.A.M., et al. Long QT syndrome caused by a large duplication in the KCNH2 (HERG) gene undetectable by current polymerase chain reaction-based exon-scanning methodologies. Heart Rhythm 3 (2006) 52-55
3. Ahmad F. The molecular genetics of arrhythmogenic right ventricular dysplasia-cardiomyopathy. Clin Invest Med 26 (2003) 167-178
4. Pardanani A., Lasho T., McLure R., Lacy M., and Tefferi A. Discordant distribution of JAK2V617F mutation in siblings with familial myeloproliferative disorders. Blood 107 (2006) 4572-4573
5. Roden D.M. Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med 259 (2006) 59-69
6. Verkerk A.O., Wilders R., Schulze-Bahr E., Beekman L., Bhuiyan Z., Bertrand J., et al. Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome. Cardiovasc Res 68 (2005) 441-453
7. Bezzina C.R., Shimizu W., Yang P., Koopmann T.T., Tanck M.W.T., Miyamoto Y., et al. Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction. Circulation 113 (2006) 338-344
8. Brugada P., and Brugada J. Right bundle-branch block, persistent ST segment elevation and sudden cardiac death - a distinct clinical and electrocardiographic syndrome - a multicenter report. J Am Coll Cardiol 20 (1992) 1391-1396
9. Chen Q., Kirsch G.E., Zhang D., Brugada R., Brugada J., Brugada P., et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392 (1998) 293-296
10. Antzelevitch Ch., Brugada P., Brugada J., Brugada R., Shimizu W., Gussak I., et al. Brugada syndrome. A decade of progress. Circ Res 91 (2002) 1114-1118
11. Schulze-Bahr E., Eckardt L., Paul M., Wichter T., and Breithardt G. Molecular genetics of the Brugada syndrome. In: Antzelevitch C., Brugada P., Brugada J., and Brugada R. (Eds). The Brugada Syndrome: From Bench to Bedside (2004), Blackwell-Futura, Oxford 42-51
12. Probst V., Le Scouarnec S., Boisseau P., Fressart V., Sacher F., Mabo P., et al. Are the SCN5A mutations really responsible for the Brugada syndrome?. Heart Rhythm 3 (2006) S219
13. Shimizu W. Acquired forms of Brugada syndrome. In: Antzelevitch C., Brugada P., Brugada J., and Brugada R. (Eds). The Brugada Syndrome: From Bench to Bedside (2004), Blackwell-Futura, Oxford 166-177
14. Roberts R. Genomics and cardiac arrhythmias. J Am Coll Cardiol 47 (2006) 9-21
15. Coronel R., Casini S., Koopmann T.T., Wilms-Schopman F.J., Verkerk A.O., de Groot J.R., et al. Right ventricular fibrosis and conduciton delay in a patient with clinical signs of Brugada syndrome. A combined electrophysiological, genetic, histopathological and computational study. Circulation 112 (2005) 2769-2777
16. Frustaci A., Priori S., Pieroni M., Chimenti C., Napolitano C., Rivolta I., et al. Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. Circulation 112 (2005) 3680-3687
17. Corrado D., Baso C., Buja G., Nava A., Rossi L., and Thiene G. Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people. Circulation 103 (2001) 710-717
18. de Bakker J.M., van Capelle F.J., Janse M.J., Tasseron S., Vermeulen J.T., de, et al. Slow conduction in the infarcted human heart. 'Zigzag' course of activation. Circulation 88 (1993) 915-926