Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

Cellular and Molecular Life Sciences

Volumn 67, Issue 15, 2010, Pages 2665-2678

  Zhao, Kai ^a,b   Zhao, Xingyu ^a,b   Tu, Yaping ^c   Miao, Qi ^a   Cao, Dongxu ^a   Duan, Wenjuan ^a,b   Sun, Yang ^a   Wang, Jincheng ^a,b   Wei, Taotao ^a   Yang, Fuyu ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bid; Chymotrypsin B; Lysosome; Mitochondrion

Indexed keywords

CASPASE 8; CHYMOTRYPSIN; CHYMOTRYPSIN B; HYDROGEN PEROXIDE; PALMITIC ACID; PROTEIN BID; UNCLASSIFIED DRUG; 4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4 BENZAMIDO 4' ISOTHIOCYANOSTILBENE 2,2' DISULFONATE; 4-BENZAMIDO-4'-ISOTHIOCYANOSTILBENE-2,2'-DISULFONATE; DRUG DERIVATIVE; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE OVEREXPRESSION; GENE SILENCING; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; POSITIVE FEEDBACK; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT; DRUG EFFECT; ENZYMOLOGY; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

4-ACETAMIDO-4'-ISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID; APOPTOSIS; CASPASE 8; CHYMOTRYPSIN; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR MEMBRANES; LYSOSOMES; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PROTEINS;

EID: 77954666815     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0356-0     Document Type: Article

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