Administration route-dependent induction of antitumor immunity by interferon-alpha gene transfer

Cancer Science

Volumn 101, Issue 7, 2010, Pages 1686-1694

  Narumi, Kenta ^a,b   Kondoh, Atsushi ^a   Udagawa, Takeshi ^a   Hara, Hidehiko ^a   Goto, Naoko ^a   Ikarashi, Yoshinori ^a   Ohnami, Shumpei ^a   Okada, Toshihide ^b   Yamagishi, Masakazu ^b   Yoshida, Teruhiko ^a   Aoki, Kazunori ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN P 15095; LIVER ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; GENE EXPRESSION; GENE TRANSFER; LYMPH NODE; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR IMMUNITY;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD11C; CELL DEATH; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA PRIMERS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; INTERFERON-ALPHA; KIDNEY NEOPLASMS; MICE; MICE, INBRED BALB C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SAFETY;

EID: 77954644929     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01578.x     Document Type: Article

References (32)

1. Caraglia M, Marra M, Pelaia G. Alpha-interferon and its effects on signal transduction pathways. J Cell Physiol 2005, 202:323-35.
2. Pfeffer LM, Dinarello CA, Herberman RB. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res 1998, 58:2489-99.
3. Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci USA 1994, 91:1198-205.
4. Santini SM, Lapenta C, Santodonato L, D'Agostino G, Belardelli F, Ferrantini M. IFN-alpha in the generation of dendritic cells for cancer immunotherapy. Handb Exp Pharmacol 2009, 188:295-317.
5. Ferrantini M, Capone I, Belardelli F. Dendritic cells and cytokines in immune rejection of cancer. Cytokine Growth Factor Rev 2008, 19:93-107.
6. Einhorn S, Grander D. Why do so many cancer patients fail to respond to interferon therapy? J Interferon Cytokine Res 1996, 16:275-81.
7. Salmon P, Le Cotonnec JY, Galazka A, Abdul-Ahad A, Darragh A. Pharmacokinetics and pharmacodynamics of recombinant human interferon-beta in healthy male volunteers. J Interferon Cytokine Res 1996, 16:759-64.
8. Zhang JF, Hu C, Geng Y. Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy. Proc Natl Acad Sci USA 1996, 93:4513-8.
9. Hottiger MO, Dam TN, Nickoloff BJ, Johnson TM, Nabel GJ. Liposome-mediated gene transfer into human basal cell carcinoma. Gene Ther 1999, 6:1929-35.
10. Ahmed CM, Wills KN, Sugarman BJ. Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice. J Interferon Cytokine Res 2001, 21:399-408.
11. Benedict WF, Tao Z, Kim CS. Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein. Mol Ther 2004, 10:525-32.
12. Studeny M, Marini FC, Dembinski JL. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004, 96:1593-603.
13. De Palma M, Mazzieri R, Politi LS. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 2008, 14:299-311.
14. Hatanaka K, Suzuki K, Miura Y. Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer. J Gene Med 2004, 6:1139.
15. Ohashi M, Yoshida K, Kushida M. Adenovirus-mediated interferon alpha gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer. Br J Cancer 2005, 93:441-9.
16. Hara H, Kobayashi A, Yoshida K. Local interferon-alpha gene therapy elicits systemic immunity in a syngeneic pancreatic cancer model in hamster. Cancer Sci 2007, 98:455-63.
17. Hara H, Kobayashi A, Narumi K. Intratumoral interferon-alpha gene transfer enhances tumor immunity after allogeneic hematopoietic stem cell transplantation. Cancer Immunol Immunother 2009, 58:1007-21.
18. Horton HM, Anderson D, Hernandez P, Barnhart KM, Norman JA, Parker SE. A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha. Proc Natl Acad Sci USA 1999, 96:1553-8.
19. Li S, Zhang X, Xia X. Intramuscular electroporation delivery of IFN-alpha gene therapy for inhibition of tumor growth located at a distant site. Gene Ther 2001, 8:400-7.
20. Aoki K, Barker C, Danthinne X, Imperiale MJ, Nabel GJ. Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro. Mol Med 1999, 5:224-31.
21. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991, 108:193-9.
22. Zhang WW, Koch PE, Roth JA. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. BioTechniques 1995, 18:444-7.
23. Yoshida K, Kondoh A, Narumi K, Yoshida T, Aoki K. Extracellular matrix interacts with interferon alpha protein: retention and display of cytotoxicity. Biochem Biophys Res Commun 2008, 376:299-304.
24. Indraccolo S, Gola E, Rosato A. Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells. Gene Ther 2002, 9:867-78.
25. Hart DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997, 90:3245-87.
26. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998, 392:245-52.
27. Santini SM, Lapenta C, Logozzi M. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 2000, 191:1777-88.
28. Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997, 9:10-6.
29. Jaffe HA, Danel C, Longenecker G. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992, 1:372-8.
30. Cristiano RJ, Smith LC, Kay MA, Brinkley BR, Woo SL. Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex. Proc Natl Acad Sci USA 1993, 90:11548-52.
31. Suzuki K, Aoki K, Ohnami S. Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model. Gene Ther 2003, 10:765-73.
32. Taguchi T. Clinical studies of recombinant interferon alfa-2a (Roferon-A) in cancer patients. Cancer 1986, 57:1705-8.