ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies)

Protein Engineering, Design and Selection

Volumn 23, Issue 4, 2010, Pages 243-249

  Olafsen, Tove ^a   Sirk, Shannon J ^a   Betting, David J ^a   Kenanova, Vania E ^a   Bauer, Karl B ^a   Ladno, Waldemar ^a   Raubitschek, Andrew A ^b   Timmerman, John M ^a   Wu, Anna M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

CD20; lymphoma model; PET; scFv

Indexed keywords

ANTIBODY FRAGMENT; B-CELL LYMPHOMA; BIODISTRIBUTIONS; CD20; DIABODY; FUNCTIONAL DIMER; GRADE B; HIGH SENSITIVITY; HIGH-CONTRAST IMAGES; HIGHER ORDER; IN-CONTROL; LYMPHOMA MODEL; MULTIMERS; PET; PET IMAGING; POST INJECTION; SCFV; SITE-SPECIFIC MODIFICATIONS; TERMINAL CYSTEINE; TIME POINTS; TUMOR TARGETING;

ANTIBODIES; DIMERS; OLIGOMERIZATION; ONCOLOGY;

TUMORS;

CD20 ANTIBODY; CYSTEINE; DIMER; IODINE 124; PROTEIN DERIVATIVE; RITUXIMAB; SCFV PROTEIN; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; IMMUNOLOGIC FACTOR; MONOCLONAL ANTIBODY; RADIOACTIVE IODINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; B CELL LYMPHOMA; CANCER DIAGNOSIS; CANCER GRADING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; MOUSE; NONHUMAN; OLIGOMERIZATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DIMERIZATION; IMMUNOLOGY; MOUSE STRAIN; SCINTISCANNING;

ANIMALS; ANTIBODIES, MONOCLONAL; DIMERIZATION; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; IODINE RADIOISOTOPES; LYMPHOMA, B-CELL; MICE; MICE, INBRED STRAINS; POSITRON-EMISSION TOMOGRAPHY; SINGLE-CHAIN ANTIBODIES;

EID: 77954637787     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp081     Document Type: Article

References (30)

1. Adams, G.P., McCartney, J.E., Tai, M.S., Oppermann, H., Huston, J.S., Stafford, W.F., 3rd, Bookman, M.A., Fand, I., Houston, L.L. and Weiner, L.M. (1993) Cancer Res., 53, 4026-4034.
2. Adams, G.P., Schier, R., McCall, A.M., Crawford, R.S., Wolf, E.J., Weiner, L.M. and Marks, J.D. (1998) Br. J. Cancer, 77, 1405-1412.
3. Arndt, K.M., Muller, K.M. and Pluckthun, A. (1998) Biochemistry, 37, 12918-12926.
4. Arndt, M.A., Krauss, J. and Rybak, S.M. (2004) FEBS Lett., 578, 257-261.
5. Bergman, Y. and Haimovich, J. (1977) Eur. J. Immunol., 7, 413-417.
6. Berk, D.A., Yuan, F., Leunig, M. and Jain, R.K. (1997) Proc. Natl Acad. Sci. USA, 94, 1785-1790.
7. Bird, R.E., Hardman, K.D., Jacobson, J.W., Johnson, S., Kaufman, B.M., Lee, S.M., Lee, T., Pope, S.H., Riordan, G.S. and Whitlow, M. (1988) Science, 242, 423-426.
8. Bubien, J.K., Zhou, L.J., Bell, P.D., Frizzell, R.A. and Tedder, T.F. (1993) J. Cell Biol., 121, 1121-1132.
9. Dolezal, O., Pearce, L.A., Lawrence, L.J., McCoy, A.J., Hudson, P.J. and Kortt, A.A. (2000) Protein Eng., 13, 565-574.
10. Holliger, P., Prospero, T. and Winter, G. (1993) Proc. Natl Acad. Sci. USA, 90, 6444-6448.
11. Huston, J.S., et al. (1988) Proc. Natl Acad. Sci. USA, 85, 5879-5883.
12. Huston, J.S., George, A.J.T., Tai, M-S., McCartney, J.E., Jin, D., Segal, D.M., Keck, P. and Oppermann, H. (1995) Single-chain Fv design and production by preparative folding. In Borrebaeck, C.A.K. (ed.), Antibody Engineering. Oxford University Press, Inc, New York, pp. 186-191.
13. Kelly, M.P., Lee, F.T., Tahtis, K., Power, B.E., Smyth, F.E., Brechbiel, M.W., Hudson, P.J. and Scott, A.M. (2008) Cancer Biother. Radiopharm., 23, 411-423.
14. Kenanova, V., et al. (2005) Cancer Res., 65, 622-631.
15. Kortt, A.A., Malby, R.L., Caldwell, J.B., Gruen, L.C., Ivancic, N., Lawrence, M.C., Howlett, G.J., Webster, R.G., Hudson, P.J. and Colman, P.M. (1994) Eur. J. Biochem., 221, 151-157.
16. Leyton, J.V., Olafsen, T., Sherman, M.A., Bauer, K.B., Aghajanian, P., Reiter, R.E. and Wu, A.M. (2009) Protein Eng. Des. Sel., 22, 209-216.
17. Li, L., Olafsen, T., Anderson, A.L., Wu, A., Raubitschek, A.A. and Shively, J.E. (2002) Bioconjug. Chem., 13, 985-995.
18. Loening, A.M. and Gambhir, S.S. (2003) Mol. Imaging, 2, 131-137.
19. Olafsen, T., et al. (2004a) Protein Eng. Des. Sel., 17, 21-27.
20. Olafsen, T., Tan, G.J., Cheung, C.W., Yazaki, P.J., Park, J.M., Shively, J.E., Williams, L.E., Raubitschek, A.A., Press, M.F. and Wu, A.M. (2004b) Protein Eng. Des. Sel., 17, 315-323.
21. Olafsen, T., Kenanova, V.E. and Wu, A.M. (2006) Nat. Protoc., 1, 2048-2060.
22. Olafsen, T., Betting, D., Kenanova, V.E., Salazar, F.B., Clarke, P., Said, J., Raubitschek, A.A., Timmerman, J.M. and Wu, A.M. (2009) J. Nucl. Med., 50, 1500-1508.
23. Robinson, M.K., Doss, M., Shaller, C., Narayanan, D., Marks, J.D., Adler, L.P., Gonzalez Trotter, D.E. and Adams, G.P. (2005) Cancer Res., 65, 1471-1478.
24. Sirk, S.J., Olafsen, T., Barat, B., Bauer, K.B. and Wu, A.M. (2008) Bioconjug. Chem., 19, 2527-2534.
25. Sundaresan, G., Yazaki, P.J., Shively, J.E., Finn, R.D., Larson, S.M., Raubitschek, A.A., Williams, L.E., Chatziioannou, A.F., Gambhir, S.S. and Wu, A.M. (2003) J. Nucl. Med., 44, 1962-1969.
26. Whitlow, M., Filpula, D., Rollence, M.L., Feng, S.L. and Wood, J.F. (1994) Protein Eng., 7, 1017-1026.
27. Worn, A. and Pluckthun, A. (1999) Biochemistry, 38, 8739-8750.
28. Wu, A.M. and Senter, P.D. (2005) Nat. Biotechnol., 23, 1137-1146.
29. Wu, A.M., Chen, W., Raubitschek, A., Williams, L.E., Neumaier, M., Fischer, R., Hu, S.Z., Odom-Maryon, T., Wong, J.Y. and Shively, J.E. (1996) Immunotechnology, 2, 21-36.
30. Yazaki, P.J., Wu, A.M., Tsai, S.W., Williams, L.E., Ikler, D.N., Wong, J.Y., Shively, J.E. and Raubitschek, A.A. (2001) Bioconjug. Chem., 12, 220-228.