DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae

Cancer Science

Volumn 101, Issue 7, 2010, Pages 1708-1716

  Yamashita, Masaki ^a,b   Toyota, Minoru ^b   Suzuki, Hiromu ^b   Nojima, Masanori ^b   Yamamoto, Eiichiro ^b   Kamimae, Seiko ^b   Watanabe, Yoshiyuki ^a   Kai, Masahiro ^b   Akashi, Hirofumi ^b   Maruyama, Reo ^b   Sasaki, Yasushi ^b   Yamano, Hiroo ^c   Sugai, Tamotsu ^d   Shinomura, Yasuhisa ^b   Imai, Kohzoh ^b   Tokino, Takashi ^b   Itoh, Fumio ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c AKITA RED CROSS HOSPITAL   (Japan)

^d IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADENOVIRUS VECTOR; ALPHA INTERFERON; BETA INTERFERON; DNA; GAMMA INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR 5; PROTEIN P53; PROTEIN P63; PROTEIN P73;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER RECURRENCE; CARCINOGENESIS; CELL GROWTH; COHORT ANALYSIS; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; STOMACH MUCOSA; UPREGULATION;

AGED; AZACITIDINE; CELL LINE, TUMOR; DNA METHYLATION; DNA, NEOPLASM; DOWN-REGULATION; FEMALE; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTORS; MALE; MIDDLE AGED; STOMACH NEOPLASMS;

EID: 77954635384     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01581.x     Document Type: Article

References (43)

1. Wright PA, Williams GT. Molecular biology and gastric carcinoma. Gut 1993, 34:145-7.
2. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007, 128:683-92.
3. Sato F, Meltzer SJ. CpG island hypermethylation in progression of esophageal and gastric cancer. Cancer 2006, 106:483-93.
4. Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M. DNA methylation and cancer pathways in gastrointestinal tumors. Pharmacogenomics 2008, 9:1917-28.
5. Ushijima T. Detection and interpretation of altered methylation patterns in cancer cells. Nat Rev Cancer 2005, 5:223-31.
6. Nojima M, Suzuki H, Toyota M. Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 2007, 26:4699-713.
7. Sato H, Suzuki H, Toyota M. Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis 2007, 28:2459-66.
8. Maruyama R, Akino K, Toyota M. Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer. Carcinogenesis 2008, 29:1312-8.
9. Suzuki H, Itoh F, Toyota M, Kikuchi T, Kakiuchi H, Imai K. Inactivation of the 14-3-3 sigma gene is associated with 5′ CpG island hypermethylation in human cancers. Cancer Res 2000, 60:4353-7.
10. Akino K, Toyota M, Suzuki H. Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. Cancer Sci 2007, 98:88-95.
11. Issa JP. DNA methylation as a therapeutic target in cancer. Clin Cancer Res 2007, 13:1634-7.
12. Smits KM, Cleven AH, Weijenberg MP. Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response. Pharmacogenomics 2008, 9:1903-16.
13. Hellebrekers DM, Lentjes MH, van den Bosch SM. GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin Cancer Res 2009, 15:3990-7.
14. Muller HM, Oberwalder M, Fiegl H. Methylation changes in faecal DNA: a marker for colorectal cancer screening? Lancet 2004, 363:1283-5.
15. Maekita T, Nakazawa K, Mihara M. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 2006, 12:989-95.
16. Nakajima T, Maekita T, Oda I. Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev 2006, 15:2317-21.
17. Takaoka A, Tamura T, Taniguchi T. Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci 2008, 99:467-78.
18. Miyamoto M, Fujita T, Kimura Y. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 1988, 54:903-13.
19. Tanaka N, Ishihara M, Lamphier MS. Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature 1996, 382:816-8.
20. Barnes BJ, Kellum MJ, Pinder KE, Frisancho JA, Pitha PM. Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death. Cancer Res 2003, 63:6424-31.
21. Mori T, Anazawa Y, Iiizumi M, Fukuda S, Nakamura Y, Arakawa H. Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53. Oncogene 2002, 21:2914-8.
22. Li Q, Tang L, Roberts PC. Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts. Mol Cancer Res 2008, 6:770-84.
23. Yang D, Thangaraju M, Greeneltch K. Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer Res 2007, 67:3301-9.
24. Lee KY, Geng H, Ng KM. Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas. Oncogene 2008, 27:5267-76.
25. Ortmann CA, Burchert A, Holzle K. Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region. Nucleic Acids Res 2005, 33:6895-905.
26. Yanagihara K, Ito A, Toge T, Numoto M. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res 1993, 53:5815-21.
27. Ishida S, Yamashita T, Nakaya U, Tokino T. Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells. Jpn J Cancer Res 2000, 91:174-80.
28. Maruyama R, Aoki F, Toyota M. Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. Cancer Res 2006, 66:4574-83.
29. Watanabe Y, Toyota M, Kondo Y. PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Clin Cancer Res 2007, 13:4786-94.
30. Sugai T, Habano W, Jiao YF. Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas. Int J Cancer 2005, 114:337-45.
31. Kusano M, Toyota M, Suzuki H. Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus. Cancer 2006, 106:1467-79.
32. Driggers PH, Ennist DL, Gleason SL. An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A 1990, 87:3743-7.
33. Shou J, Soriano R, Hayward SW, Cunha GR, Williams PM, Gao WQ. Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A 2002, 99:2830-5.
34. Karpf AR, Peterson PW, Rawlins JT. Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells. Proc Natl Acad Sci U S A 1999, 96:14007-12.
35. Satoh A, Toyota M, Ikeda H. Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells. Oncogene 2004, 23:8876-86.
36. Reu FJ, Bae SI, Cherkassky L. Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J Clin Oncol 2006, 24:3771-9.
37. McGough JM, Yang D, Huang S. DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. Mol Cancer Res 2008, 6:1841-51.
38. Tshuikina M, Jernberg-Wiklund H, Nilsson K, Oberg F. Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. Exp Hematol 2008, 36:1673-81.
39. Ahlquist DA. Next generation stool DNA testing: expanding the scope. Gastroenterology 2009, 136:2068-73.
40. Watanabe Y, Kim HS, Castoro RJ. Sensitive and specific detection of early gastric cancer using DNA methylation analysis of gastric washes. Gastroenterology 2009, 136:2149-58.
41. Takeshima H, Yamashita S, Shimazu T, Niwa T, Ushijima T. The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res 2009, 19:1974-82.
42. Barnes BJ, Field AE, Pitha-Rowe PM. Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. J Biol Chem 2003, 278:16630-41.
43. Kulaeva OI, Draghici S, Tang L, Kraniak JM, Land SJ, Tainsky MA. Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. Oncogene 2003, 22:4118-27.