Blockade of the kinin B1 receptor ameloriates glomerulonephritis

Journal of the American Society of Nephrology

Volumn 21, Issue 7, 2010, Pages 1157-1164

  Klein, Julie ^a,b   Gonzalez, Julien ^a,b   Decramer, Stéphane ^a,c   Bandin, Flavio ^a,c   Neau, Eric ^a,b   Salant, David J ^d   Heeringa, Peter ^e   Pesquero, Joao Bosco ^f   Schanstra, Joost Peter ^a,b   Bascands, Jean Loup ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c CHU PURPAN   (France)

^d BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; SSR 240612; UNCLASSIFIED DRUG;

ADULT; ANAPHYLACTOID PURPURA; ANCA ASSOCIATED VASCULITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLOMERULONEPHRITIS; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY DISEASE; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SCHOOL CHILD; UPREGULATION;

EID: 77954603954     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2009090887     Document Type: Article

References (36)

1. Kitching AR, Holdsworth SR, Hickey MJ: Targeting leukocytes in immune glomerular diseases. Curr Med Chem 15: 448-458, 2008
2. Regoli D, Barabe J: Pharmacology of bradykinin and related kinins. Pharmacol Rev 32: 1-46, 1980
3. Leeb-Lundberg LM, Marceau F, Muller-Esterl W, Pettibone DJ, Zuraw BL: International union of pharmacology: XLV. Classification of the kinin receptor family: From molecular mechanisms to pathophysiological consequences. Pharmacol Rev 57: 27-77, 2005
4. Marceau F: Kinin B1 receptors: A review. Immunopharmacology 30: 1-26, 1995
5. Marin-Castano ME, Schanstra JP, Praddaude F, Pesquero JB, Ader JL, Girolami JP, Bascands JL: Differential induction of functional B1-bradykinin receptors along the rat nephron in endotoxin induced inflammation. Kidney Int 54: 1888-1898, 1998
6. Schanstra JP, Marin-Castano ME, Praddaude F, Tack I, Ader JL, Girolami JP, Bascands JL: Bradykinin B(1) receptor-mediated changes in renal hemodynamics during endotoxin-induced inflammation. J Am Soc Nephrol 11: 1208-1215, 2000 (Pubitemid 30416216)
7. Schanstra JP, Bataille E, Marin Castano ME, Barascud Y, Hirtz C, Pesquero JB, Pecher C, Gauthier F, Girolami JP, Bascands JL: The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts. J Clin Invest 101: 2080-2091, 1998 (Pubitemid 28244092)
8. Phagoo SB, Poole S, Leeb-Lundberg LM: Autoregulation of bradykinin receptors: Agonists in the presence of interleukin-1beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts. Mol Pharmacol 56: 325-333, 1999 (Pubitemid 29347608)
9. Tiffany CW, Burch RM: Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages. FEBS Lett 247: 189-192, 1989 (Pubitemid 19129244)
10. Ahluwalia A, Perretti M: Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse. J Immunol 156: 269-274, 1996 (Pubitemid 3024777)
11. Bockmann S, Paegelow I: Kinins and kinin receptors: Importance for the activation of leukocytes. J Leukoc Biol 68: 587-592, 2000
12. Pesquero JB, Araujo RC, Heppenstall PA, Stucky CL, Silva JA Jr, Walther T, Oliveira SM, Pesquero JL, Paiva AC, Calixto JB, Lewin GR, Bader M: Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Proc Natl Acad Sci U S A 97: 8140-8145, 2000 (Pubitemid 30460786)
13. Souza DG, Lomez ES, Pinho V, Pesquero JB, Bader M, Pesquero JL, Teixeira MM: Role of bradykinin B2 and B1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury. J Immunol 172: 2542-2548, 2004 (Pubitemid 38182405)
14. Duchene J, Ahluwalia A: The kinin B(1) receptor and inflammation: New therapeutic target for cardiovascular disease. Curr Opin Pharmacol 9: 125-131, 2009
15. Campos MM, Leal PC, Yunes RA, Calixto JB: Non-peptide antagonists for kinin B1 receptors: New insights into their therapeutic potential for the management of inflammation and pain. Trends Pharmacol Sci 27: 646-651, 2006
16. Gougat J, Ferrari B, Sarran L, Planchenault C, Poncelet M, Maruani J, Alonso R, Cudennec A, Croci T, Guagnini F, Urban-Szabo K, Martinolle JP, Soubrie P, Finance O, Le Fur G: SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3- [[(6-ethoxy-2-naphthyl)sulfonyl]amino]propanoyl) amino]-3-(4-[[2R,6S)-2,6- dimethylpiperidinyl]methyl]pheny l)-N-isopropyl-N-methylpropanamide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: Biochemical and pharmacological characterization. J Pharmacol Exp Ther 309: 661-669, 2004 (Pubitemid 38542620)
17. Hara DB, Leite DF, Fernandes ES, Passos GF, Guimaraes AO, Pesquero JB, Campos MM, Calixto JB: The relevance of kinin B1 receptor upregulation in a mouse model of colitis. Br J Pharmacol 154: 1276-1286, 2008
18. Pietrovski EF, Otuki MF, Regoli D, Bader M, Pesquero JB, Cabrini DA, Zampronio AR: The non-peptide kinin receptor antagonists FR 173657 and SSR 240612: Preclinical evidence for the treatment of skin inflammation. Regul Pept 152: 67-72, 2009
19. Dias JP, Ismael MA, Pilon M, de Champlain J, Ferrari B, Carayon P, Couture R: The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Br J Pharmacol 152: 280-287, 2007 (Pubitemid 47517611)
20. Quintao NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM, Calixto JB: Neuropathic pain-like behavior after brachial plexus avulsion in mice: The relevance of kinin B1 and B2 receptors. J Neurosci 28: 2856-2863, 2008
21. Klein J, Gonzalez J, Duchene J, Esposito L, Pradere JP, Neau E, Delage C, Calise D, Ahluwalia A, Carayon P, Pesquero JB, Bader M, Schanstra JP, Bascands JL: Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. FASEB J 23: 134-142, 2009
22. Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ, Gutierrez-Ramos JC: RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med 185: 1371-1380, 1997
23. Segerer S, Nelson PJ, Schlondorff D: Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 11: 152-176, 2000 (Pubitemid 30020438)
24. Tesch GH, Schwarting A, Kinoshita K, Lan HY, Rollins BJ, Kelley VR: Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J Clin Invest 103: 73-80, 1999 (Pubitemid 29031165)
25. Wang PH, Cenedeze MA, Campanholle G, Malheiros DM, Torres HA, Pesquero JB, Pacheco-Silva A, Camara NO: Deletion of bradykinin B1 receptor reduces renal fibrosis. Int Immunopharmacol 9: 653-657, 2009
26. Kahn R, Herwald H, Muller-Esterl W, Schmitt R, Sjogren AC, Truedsson L, Karpman D: Contact-system activation in children with vasculitis. Lancet 360: 535-541, 2002
27. Ricupero DA, Romero JR, Rishikof DC, Goldstein RH: Des-Arg(10)-kallidin engagement of the B1 receptor stimulates type I collagen synthesis via stabilization of connective tissue growth factor mRNA. J Biol Chem 275: 12475-12480, 2000
28. Cook HT, Singh SJ, Wembridge DE, Smith J, Tam FW, Pusey CD: Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats. Kidney Int 55: 1319-1326, 1999 (Pubitemid 29157130)
29. Duffield JS, Tipping PG, Kipari T, Cailhier JF, Clay S, Lang R, Bonventre JV, Hughes J: Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am J Pathol 167: 1207-1219, 2005 (Pubitemid 41541408)
30. Schulze-Topphoff U, Prat A, Prozorovski T, Siffrin V, Paterka M, Herz J, Bendix I, Ifergan I, Schadock I, Mori MA, Van Horssen J, Schroter F, Smorodchenko A, Han MH, Bader M, Steinman L, Aktas O, Zipp F: Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nat Med 15: 788-793, 2009
31. Gama Landgraf R, Sirois P, Jancar S: Differential modulation of murine lung inflammation by bradykinin B1 and B2 selective receptor antagonists. Eur J Pharmacol 460: 75-83, 2003 (Pubitemid 36078488)
32. Scholz J, Lukacs-Kornek V, Engel DR, Specht S, Kiss E, Eitner F, Floege J, Groene HJ, Kurts C: Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol 19: 527-537, 2008 (Pubitemid 351355396)
33. Heymann F, Meyer-Schwesinger C, Hamilton-Williams EE, Hammerich L, Panzer U, Kaden S, Quaggin SE, Floege J, Grone HJ, Kurts C: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest 119: 1286-1297, 2009
34. Kluth DC, Erwig LP, Rees AJ: Multiple facets of macrophages in renal injury. Kidney Int 66: 542-557, 2004
35. Schanstra JP, Neau E, Drogoz P, Arevalo Gomez MA, Lopez Novoa JM, Calise D, Pecher C, Bader M, Girolami JP, Bascands JL: In vivo bradykinin B2 receptor activation reduces renal fibrosis. J Clin Invest 110: 371-379, 2002
36. Heeringa P, van Goor H, Itoh-Lindstrom Y, Maeda N, Falk RJ, Assmann KJ, Kallenberg CG, Jennette JC: Lack of endothelial nitric oxide synthase aggravates murine accelerated anti-glomerular basement membrane glomerulonephritis. Am J Pathol 156: 879-888, 2000 (Pubitemid 30626947)