Does telomerase reverse transcriptase induce functional de-differentiation of human endothelial cells?

Cellular and Molecular Life Sciences

Volumn 67, Issue 14, 2010, Pages 2451-2465

  Baumer, Yvonne ^a   Funk, Dorothee ^a   Schlosshauer, Burkhard ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cell de differentiation; Immortalized endothelial cells; Telomerase

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; TELOMERASE REVERSE TRANSCRIPTASE; 3,3' DIOCTADECYLINDOCARBOCYANINE; 3,3'-DIOCTADECYLINDOCARBOCYANINE; CARBOCYANINE; CELL ADHESION MOLECULE; GAMMA INTERFERON; LOW DENSITY LIPOPROTEIN; PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; VON WILLEBRAND FACTOR;

ARTICLE; CELL ADHESION; CELL DEDIFFERENTIATION; CELL IMMORTALIZATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PROTEIN EXPRESSION; UPREGULATION; CELL CULTURE; CELL MOTION; CELL TRANSFORMATION; CYTOLOGY; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR CLONING; PERMEABILITY; PHYSIOLOGY;

CARBOCYANINES; CELL ADHESION MOLECULES; CELL DEDIFFERENTIATION; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CLONING, MOLECULAR; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON-GAMMA; LIPOPROTEINS, LDL; PERMEABILITY; PROTEINS; TELOMERASE; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON WILLEBRAND FACTOR;

EID: 77954589987     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0349-z     Document Type: Article

References (63)

1. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR (1997) Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959
2. Lue NF (2004) Adding to the ends: what makes telomerase processive and how important is it? Bioessays 26:955-962
3. Miura T, Katakura Y, Yamamoto K, Uehara N, Tsuchiya T, Kim EH, Shirahata S (2001) Neural stem cells lose telomerase activity upon differentiating into astrocytes. Cytotechnology 36:137-144
4. O'Connor MS, Carlson ME, Conboy IM (2009) Differentiation rather than aging of muscle stem cells abolishes their telomerase activity. Biotechnol Prog 25:1130-1137
5. Wang S, Zhao Y, Hu C, Zhu J (2009) Differential repression of human and mouse TERT genes during cell differentiation. Nucleic Acids Res 37:2618-2629
6. Love WK, Berletch JB, Andrews LG, Tollefsbol TO (2008) Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells. Int J Oncol 32:625-631
7. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352
8. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP (1999) Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 21:111-114
9. Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE, Shay JW (1999) Absence of cancerassociated changes in human fibroblasts immortalized with telomerase. Nat Genet 21:115-118
10. Chapman EJ, Kelly G, Knowles MA (2008) Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Mol Cancer Res 6:1154-1168
11. Techangamsuwan S, Kreutzer R, Kreutzer M, Imbschweiler I, Rohn K, Wewetzer K, Baumgartner W (2009) Transfection of adult canine Schwann cells and olfactory ensheathing cells at early and late passage with human TERT differentially affects growth factor responsiveness and in vitro growth. J Neurosci Methods 176:112-120
12. Brandt S (2010) TERT over-expression affects the growth of myocardial tissue derived from mouse embryonic stem cells. Differentiation 79:1-8
13. Dudek SM, Garcia JG (2001) Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91:1487-1500
14. Michel CC, Curry FE (1999) Microvascular permeability. Physiol Rev 79:703-761
15. Mehta D, Malik AB (2006) Signaling mechanisms regulating endothelial permeability. Physiol Rev 86:279-367
16. Schlegel N, Baumer Y, Drenckhahn D, Waschke J (2009) Lipopolysaccharide- induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro. Crit Care Med 37:1735-1743
17. Libby P, Aikawa M, Jain MK (2006) Vascular endothelium and atherosclerosis. Handb Exp Pharmacol 176:285-306
18. Spinetti G, Kraenkel N, Emanueli C, Madeddu P (2008) Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies. Cardiovasc Res 78:265-273
19. Pektok E, Nottelet B, Tille JC, Gurny R, Kalangos A, Moeller M, Walpoth BH (2008) Degradation and healing characteristics of small-diameter poly(epsilon-caprolactone) vascular grafts in the rat systemic arterial circulation. Circulation 118:2563-2570
20. Tassiopoulos AK, Greisler HP (2000) Angiogenic mechanisms of endothelialization of cardiovascular implants: a review of recent investigative strategies. J Biomater Sci Polym Ed 11:1275-1284
21. de Mel A, Jell G, Stevens MM, Seifalian AM (2008) Biofunctionalization of biomaterials for accelerated in situ endothelialization: a review. Biomacromolecules 9:2969-2979
22. Rojas A, Gonzalez I, Figueroa H (2009) Stopping the use of false "endothelial" cell lines. Int Immunopharmacol 9:258
23. Rojas A, Gonzalez I, Figueroa H (2008) Cell line cross-contamination in biomedical research: a call to prevent unawareness. Acta Pharmacol Sin 29:877-880
24. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015
25. Dalbagni G, Han W, Zhang ZF, Cordon-Cardo C, Saigo P, Fair WR, Herr H, Kim N, Moore MA (1997) Evaluation of the telomeric repeat amplification protocol (TRAP) assay for telomerase as a diagnostic modality in recurrent bladder cancer. Clin Cancer Res 3:1593-1598
26. Kuschel C, Steuer H, Maurer AN, Kanzok B, Stoop R, Angres B (2006) Cell adhesion profiling using extracellular matrix protein microarrays. Biotechniques 40:523-531
27. Schlegel N, Burger S, Golenhofen N, Walter U, Drenckhahn D, Waschke J (2008) The role of VASP in regulation of cAMP-and Rac 1-mediated endothelial barrier stabilization. Am J Physiol Cell Physiol 294:C178-C188
28. Voyta JC, Via DP, Butterfield CE, Zetter BR (1984) Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J Cell Biol 99:2034-2040
29. Dreesmann L, Mittnacht U, Lietz M, Schlosshauer B (2009) Nerve fibroblast impact on Schwann cell behavior. Eur J Cell Biol 88:285-300
30. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785-795
31. Luiten RM, Pene J, Yssel H, Spits H (2003) Ectopic hTERT expression extends the life span of human CD4 + helper and regulatory T-cell clones and confers resistance to oxidative stressinduced apoptosis. Blood 101:4512-4519
32. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK (2001) LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res 61:8079-8084
33. Macera-Bloch L, Houghton J, Lenahan M, Jha KK, Ozer HL (2002) Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis. J Cell Physiol 190:332-344
34. Bian C, Zhao K, Tong GX, Zhu YL, Chen P (2005) Immortalization of human umbilical vein endothelial cells with telomerase reverse transcriptase and simian virus 40 large T antigen. J Zhejiang Univ Sci B 6:631-636
35. Steinert S, Shay JW, Wright WE (2000) Transient expression of human telomerase extends the life span of normal human fibroblasts. Biochem Biophys Res Commun 273:1095-1098
36. Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A, Bronstein A, Chiu C-P, Herron GS (1999) Human endothelial cell life extension by telomerase expression. J Biol Chem 274:26141-26148
37. Freedman DA, Folkman J (2004) Maintenance of G1 checkpoint controls in telomerase-immortalized endothelial cells. Cell Cycle 3:811-816
38. Buser R, Montesano R, Garcia I, Dupraz P, Pepper MS (2006) Bovine microvascular endothelial cells immortalized with human telomerase. J Cell Biochem 98:267-286
39. Krump-Konvalinkova V, Bittinger F, Unger RE, Peters K, Lehr HA, Kirkpatrick CJ (2001) Generation of human pulmonary microvascular endothelial cell lines. Lab Invest 81:1717-1727
40. Jaffe EA, Nachman RL, Becker CG, Minick CR (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745-2756
41. Anders E, Alles JU, Delvos U, Potzsch B, Preissner KT, Muller-Berghaus G (1987) Microvascular endothelial cells from human omental tissue: modified method for long-term cultivation and new aspects of characterization. Microvasc Res 34:239-249
42. Albelda SM, Buck CA (1990) Integrins and other cell adhesion molecules. FASEB J 4:2868-2880
43. Hewett PW, Murray JC (1996) Coexpression of flt-1, flt-4 and KDR in freshly isolated and cultured human endothelial cells. Biochem Biophys Res Commun 221:697-702
44. Klagsbrun M, D'Amore PA (1996) Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev 7:259-270
45. Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco LP, Dejana E (1992) A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol 118:1511-1522
46. Leach L, Clark P, Lampugnani MG, Arroyo AG, Dejana E, Firth JA (1993) Immunoelectron characterisation of the inter-endothelial junctions of human term placenta. J Cell Sci 104(Pt 4):1073-1081
47. Takahashi K, Sawasaki Y, Hata J, Mukai K, Goto T (1990) Spontaneous transformation and immortalization of human endothelial cells. In Vitro Cell Dev Biol 26:265-274
48. van Leeuwen EB, Veenstra R, van Wijk R, Molema G, Hoekstra A, Ruiters MH, van der Meer J (2000) Characterization of immortalized human umbilical and iliac vein endothelial cell lines after transfection with SV40 large T-antigen. Blood Coagul Fibrinolysis 11:15-25
49. Unger RE, Krump-Konvalinkova V, Peters K, Kirkpatrick CJ (2002) In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R. Microvasc Res 64:384-397
50. Lip GY, Blann AD (1995) von Willebrand factor and its relevance to cardiovascular disorders. Br Heart J 74:580-583
51. Dejana E, Corada M, Lampugnani MG (1995) Endothelial cellto-cell junctions. FASEB J 9:910-918
52. Plendl J, Neumuller C, Vollmar A, Auerbach R, Sinowatz F (1996) Isolation and characterization of endothelial cells from different organs of fetal pigs. Anat Embryol (Berl) 194:445-456
53. Lawley TJ, Kubota Y (1989) Induction of morphologic differentiation of endothelial cells in culture. J Invest Dermatol 93:59S-61S
54. Grant DS, Tashiro K, Segui-Real B, Yamada Y, Martin GR, Kleinman HK (1989) Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro. Cell 58:933-943
55. Bachetti T, Morbidelli L (2000) Endothelial cells in culture: a model for studying vascular functions. Pharmacol Res 42:9-19
56. Shizukuda Y, Tang S, Yokota R, Ware JA (1999) Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circ Res 85:247-256
57. Zheng ZZ, Liu ZX (2007) CD151 gene delivery increases eNOS activity and induces ECV304 migration, proliferation and tube formation. Acta Pharmacol Sin 28:66-72
58. Bouis D, Hospers GA, Meijer C, Molema G, Mulder NH (2001) Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research. Angiogenesis 4:91-102
59. Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM (2000) Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvasc Res 59:265-277
60. Michel CC, Neal CR (1999) Openings through endothelial cells associated with increased microvascular permeability. Microcirculation 6:45-54
61. Breslin JW, Pappas PJ, Cerveira JJ, Hobson RW II, Duran WN (2003) VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol Heart Circ Physiol 284:H92-H100
62. Kazakoff PW, McGuire TR, Hoie EB, Cano M, Iversen PL (1995) An in vitro model for endothelial permeability: assessment of monolayer integrity. In Vitro Cell Dev Biol Anim 31:846-852
63. Lal BK, Varma S, Pappas PJ, Hobson RW II, Duran WN (2001) VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc Res 62:252-262