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Volumn 12, Issue 7, 2010, Pages 1301-1305

An E-factor minimized protocol for the preparation of methyl β-hydroxy esters

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EID: 77954568163     PISSN: 14639262     EISSN: 14639270     Source Type: Journal    
DOI: 10.1039/c004461j     Document Type: Article
Times cited : (57)

References (69)
  • 40
    • 85032764163 scopus 로고    scopus 로고
    • Amberlite IRA900F is a trimethylammonium fluoride on macroreticular polystyrene resin which is commercially available from Aldrich as “Fluoride on polymer support” or as “Fluoride on Amberlyst A-26”. Commercially available Amb-F is a hygroscopic solid which contains ca. 20 wt% of water. In general we have used water-free Amb-F which was obtained by drying the commercial product under vacuum
    • Amberlite IRA900F is a trimethylammonium fluoride on macroreticular polystyrene resin which is commercially available from Aldrich as “Fluoride on polymer support” or as “Fluoride on Amberlyst A-26”. Commercially available Amb-F is a hygroscopic solid which contains ca. 20 wt% of water. In general we have used water-free Amb-F which was obtained by drying the commercial product under vacuum.
  • 62
    • 85032753347 scopus 로고    scopus 로고
    • Amberlyst-15, wet or dry, and Amberlite IRC-86 were also used but gave unsatisfactory results
    • Amberlyst-15, wet or dry, and Amberlite IRC-86 were also used but gave unsatisfactory results.
  • 67
    • 85032770401 scopus 로고    scopus 로고
    • Calculation of E-factor has been performed in the understanding that not all the cases reported in the literature have paid attention to waste minimization in the setting of protocols. Besides the solvent used for the work-up procedures, it can certainly be concluded that in our case the most significant contribution to the E-factor minimization is due to the elimination of aqueous HCl waste, thanks to the novel de-silylation process promoted by Dowex 50Wx8 H
    • Calculation of E-factor has been performed in the understanding that not all the cases reported in the literature have paid attention to waste minimization in the setting of protocols. Besides the solvent used for the work-up procedures, it can certainly be concluded that in our case the most significant contribution to the E-factor minimization is due to the elimination of aqueous HCl waste, thanks to the novel de-silylation process promoted by Dowex 50Wx8 H.
  • 68
    • 33845279280 scopus 로고
    • Since Amb-F is a fluoride source with a very large counter ion (polystyryl trimethylammonium) we have not taken into consideration the formation of a hexavalent silicon species (see)
    • Since Amb-F is a fluoride source with a very large counter ion (polystyryl trimethylammonium) we have not taken into consideration the formation of a hexavalent silicon species (see A. Boudin G. Cerveau C. Chuit R. J. P. Corriu C. Reyé Organometallics 1988 7 1165-1171.).
    • (1988) Organometallics , vol.7 , pp. 1165-1171
    • Boudin, A.1    Cerveau, G.2    Chuit, C.3    Corriu, R.J.P.4    Reyé, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.