Inhibition of the mechanical activity of mouse ileum by cactus pear (Opuntia ficus Indica, L, Mill.) fruit extract and its pigment indicaxanthin

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 13, 2010, Pages 7565-7571

  Baldassano, S ^a   Tesoriere, L ^a   Rotundo, A ^a   Serio, R ^a   Livrea, M A ^a   Mule F ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Antispasmodic effect; Indicaxanthin; Intestinal smooth muscle; Opuntia ficus indica

Indexed keywords

BETAXANTHIN; INDICAXANTHIN; PLANT EXTRACT; PYRIDINE DERIVATIVE;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; FRUIT; GASTROINTESTINAL MOTILITY; ILEUM; MALE; MOUSE; OPUNTIA; PHYSIOLOGY; DRUG EFFECTS;

ANIMALS; BETAXANTHINS; FRUIT; GASTROINTESTINAL MOTILITY; ILEUM; MALE; MICE; MICE, INBRED C57BL; OPUNTIA; PLANT EXTRACTS; PYRIDINES;

CACTACEAE; OPUNTIA; OPUNTIA FICUS-INDICA; PYRUS;

EID: 77954561666     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf100434e     Document Type: Article

References (47)

1. Feugang, J. M.; Konarski, P.; Zou, D.; Stintzing, F. C.; Zou, C. Nutritional and medicinal use of Cactus pear (Opuntia spp.) cladodes and fruits. Front. Biosci. 2006, 11, 2574-2589.
2. Stintzing, F. C.; Carle, R. Cactus stems (Opuntia spp.): A review of their chemistry, technology, and uses. Molec. Nutr. Food Res. 2005, 49, 175-194.
3. Galati, E. M.; Monforte, M. T.; Tripodo, M. M.; D'Aquino, A.; Mondello, M. R. Antiulcer activity of Opuntia ficus-indica (L.) Mill. (Cactaeceae): ultrastructural study. J Ethnopharmacol. 2001, 76, 1-9.
4. Lee, E. B.; Hyun, J. E.; Li, D. W.; Moon, Y. I. Effects of Opuntia ficus-indica var. saboten stem on gastric damages in rats. Arch. Pharm. Res. 2002, 25, 67-70.
5. Galati, E. M.; Tripodo, M. M.; Trovato, A.; Miceli, N.; Monforte, M. T. Biological effect of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. Note I: diuretic activity. J. Ethnopharmacol. 2002, 79, 17-21.
6. Fernandez, M. L.; Lin, E. C.; Trejo, A.; McNamara, D. J. Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs. J. Nutr. 1992, 122, 2330-2340.
7. Frati, A. C.; Gordillo, B. E.; Altamirano, P.; Ariza, C. R.; Cortés- Franco, R.; Chavez-Negrete, A. Acute hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 1990, 13, 455-456. (Pubitemid 20109491)
8. Frati, A. C.; Jimenez, E.; Ariza, C. R. Hypoglycemic effect of Opuntia ficus-indica in non insulin-dependent diabetes mellitus patients. Phytother. Res. 1990, 4, 195-197.
9. Ibañez-Camacho, R.; Meckes-Lozoya, M.; Mellado-Campos, V. The hypoglycemic effect of Opuntia streptacantha studied in different animal experimental models. J. Ethnopharmacol. 1983, 7, 175-181. (Pubitemid 13087149)
10. Palumbo, B.; Efthimiou, Y.; Stamatopoulos, J.; Oguogho, A.; Budinsky, A.; Palumbo, R.; Sinzinger, H. Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia. Nucl. Med. Rev. Cent. East Eur. 2003, 6, 35-9.
11. Wolfram, R.; Budinsky, A.; Efthimiou, Y.; Stomatopoulos, J.; Oguogho, A.; Sinzinger, H. Daily prickly pear consumption improves platelet function. Prostaglandins Leukot. Essen. Fatty Acids 2003, 69, 61-66.
12. Tesoriere, L.; Butera, D.; Pintaudi, A. M.; Allegra, M.; Livrea, M. A. Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am. J. Clin. Nutr. 2004, 80, 391-395.
13. Zou, D. M.; Brewer, M.; Garcia, F.; Feugang, J. M.; Wang, J.; Zang, R.; Liu, H.; Zou, C. Cactus pear: a natural product in cancer chemoprevention. Nutr. J. 2005, 4, 2-5.
14. Zakharova, N. S.; Petrova, T. A. Relationship between the structure and antioxidant activity of various betalains. Prik. Biokhim. Mikrobiol. 1998, 34, 199-202.
15. Kanner, J.; Harel, S.; Granit, R. Betalains-a new class of dietary cationized antioxidants. J. Agric. Food Chem. 2001, 49, 5178-85.
16. Gentile, C.; Tesoriere, L.; Allegra, M.; Livrea, M. A.; D'Alessio, P. Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression. Ann. N.Y. Acad. Sci. 2004, 1028, 481-486.
17. Tesoriere, L.; Butera, D.; Allegra, M.; Fazzari, M.; Livrea, M. A. Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. J. Agric. Food Chem. 2005, 53, 1266-1270.
18. Kapadia, G. J.; Tokuda, H.; Konoshima, T.; Nishino, H. Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett. 1996, 100, 211-214. (Pubitemid 26053946)
19. Reddy, M. K.; Alexander-Lindo, R. L.; Nair, M. G. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J. Agric. Food Chem. 2005, 53, 9268-9273.
20. Sreekanth, D.; Arunasree, M. K.; Roy, K. R.; Chandramohan Reddy, T.; Reddy, G. V.; Reddanna, P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562. Phytomedicine 2007, 14, 739-746. (Pubitemid 47539100)
21. Strack, D.; Vogt, T.; Schliemann, W. Recent advances in betalain research. Phytochemistry 2003, 62, 247-269.
22. Palombo, E. A. Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function. Phytother. Res. 2006, 20, 717-724.
23. 1 receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle. Eur. J. Pharmacol. 2008, 582, 132-138.
24. Zizzo, M. G.; Mulè, F.; Serio, R. Interplay between PACAP andNO in mouse ileum. Neuropharmacology 2004, 46, 449-455. (Pubitemid 38223878)
25. Butera, D.; Tesoriere, L.; Di Gaudio, F.; Bongiorno, A.; Allegra, M.; Pintaudi, A. M.; Kohen, R.; Livrea, M. A. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J. Agric. Food Chem. 2002, 50, 895-901.
26. Tesoriere, L.; Allegra, M.; Bufera, D.; Gentile, C.; Livrea, M. A. Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. Free Radic. Res. 2006, 40, 753-761.
27. Piattelli, M.; Minale, L.; Prota, G. Isolation structure and absolute configuration of indicaxanthin. Tetrahedron 1964, 20, 2325-2329.
28. Amira, S.; Rotondo, A.; Mulè, F. Relaxant effects of flavonoids on the mouse isolated stomach: structure-activity relationships. Eur. J. Pharmacol. 2008, 599, 126-130.
29. Zizzo, M. G.; Mulè, F.; Serio, R. Mechanisms underlying the nitric oxide inhibitory effects in mouse ileal longitudinal muscle. Can. J. Physiol. Pharmacol. 2005, 83, 805-810.
30. Murthy, K. S.; Makhlouf, G. M. Vasoactive intestinal peptide/ pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2. J. Biol. Chem. 1994, 269, 15977-15980.
31. Xue, C.; Pollock, J.; Schmidt, H. H.; Ward, S. M.; Sanders, K. M. Expression of nitric oxide synthase immunoreactivity by interstitial cells of the canine proximal colon. J. Auton. Nerv. Syst. 1994, 49, 1-14.
32. Gilani, A. H.; Khan, A. U.; Ghayur, M. N.; Ali, S. F.; Herzig, J. W. Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K + -channel activation. Basic Clin. Pharmol. Toxicol. 2006, 99, 365-373.
33. Gilani, A. H.; Khan, A. U.; Jabeen, Q.; Subhan, F.; Ghafar, R. Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K + channel activation. J. Ethnopharmacol. 2005, 100, 347-352.
34. Gilani, A. H.; Mehmood, M. H.; Janbaz, K. H.; Khan, A. U.; Saeed, S. A. Ethnopharmacological studies on antispasmodic and antiplatelet activities of Ficus carica. J. Ethnopharmacol. 2008, 119, 1-5.
35. Koh, S. D.; Ward, S. M.; Dick, G. M.; Epperson, A.; Bonner, H. P.; Sanders, K. M.; Horowitz, B.; Kenyon, J. L. Contribution of delayed rectifier potassium currents to the electrical activity of murine colonic smooth muscle. J. Physiol. 1999, 515, 475-487.
36. Bolton, T. B. Mechanism of action of transmitters and other substances on smooth muscles. Physiol. Rev. 1979, 59, 606-718.
37. Godfraind, T.; Miller, R.; Wibo, M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev. 1986, 38, 321-416.
38. 3. J. Cell Sci. 2002, 115, 2207-2218.
39. 2×1 receptors in mouse ileum, bladder and reproductive systems. Auton. Neurosci. 2001, 92, 56-64.
40. Stintzing, F. C.; Herbach, K. M.; Mosshammer, M. R.; Carle, R.; Yi, W.; Sellappan, S.; Akoh, C. C.; Bunch, R.; Felker, P. Color, betalain pattern, and antioxidant properties of cactus pear (Opuntia spp.) clones. J. Agric. Food Chem. 2005, 53, 442-451.
41. Tesoriere, L.; Fazzari, M.; Allegra, M.; Livrea, M. A. Biothiols, taurine, and lipid-soluble antioxidants in the edible pulp of Sicilian cactus pear (Opuntia ficus indica) fruits and changes of bioactive juice components upon industrial processing. J. Agric. Food Chem. 2005, 53, 7851-7855.
42. Hayashi, E.; Shinozuka, K.; Maeda, T.; Takeda, M. Effect of ascorbate on the contractile response induced by DMPP in guineapig ileal longitudinal muscle strip. Eur. J. Pharmacol. 1983, 89, 229-234.
43. Poćwiardowska-Ciara, E.; Korolkiewicz, Z. Ascorbic acid, PGE2 and acetylcholine interaction: the effect on isolated smooth muscle. Acta Physiol. Pol. 1986, 37, 18-24.
44. Terada, M.; Hayashi, S.; Hayashi, E. Spasmogenic effects of L-ascorbic acid on the guinea pig isolated ileum preparation. Jpn. J. Pharmacol. 1980, 30, 21-27.
45. Mosshammer, M. R.; Rohe, M.; Stintzing, F. C.; Carle, R. Stability of yellow-orange cactus pear (Opuntia ficus-indica, L. Mill. Cv. Gialla) betalains as affected by the juice matrix and selected food additives. Eur. Food Res. Technol. 2007, 225, 21-32.
46. Turco-Liveri, M. L.; Sciascia, L.; Allegra, M.; Tesoriere, L.; Livrea, M. A. Partition of indicaxanthin in membrane biomimeticsystems. A kinetic and modelling approach. J. Agric. Food Chem. 2009, 57, 10959-10963.
47. Tesoriere, L.; Allegra, M.; Butera, D.; Livrea, M. A. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am. J. Clin. Nutr. 2004, 80, 941-945.