Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation

Journal of Ethnopharmacology

Volumn 100, Issue 3, 2005, Pages 347-352

  Gilani, Anwar H ^a   Khan, Arif Ullah ^a   Jabeen, Qaiser ^a   Subhan, Fazal ^b   Ghafar, Rukhsana ^b  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b UNIVERSITY OF PESHAWAR   (Pakistan)

Author keywords

Antispasmodic; Hyoptensive; K+channel opener; Valeriana wallichii

Indexed keywords

ANTIHYPERTENSIVE AGENT; CROMAKALIM; GLIBENCLAMIDE; PLANT EXTRACT; POTASSIUM CHANNEL; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG; VALERIANA WALLICHII EXTRACT; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; GUINEA PIG; ILEUM; MALE; MEDICINAL PLANT; NONHUMAN; RAT; VALERIANA WALLICHII;

ANIMALS; CROMAKALIM; GLYBURIDE; GUINEA PIGS; HYPOGLYCEMIC AGENTS; ILEUM; JEJUNUM; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; PLANT EXTRACTS; PLANT ROOTS; POTASSIUM CHANNELS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; VALERIAN; VASCULAR RESISTANCE;

CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; VALERIANA WALLICHII;

EID: 23944492135     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.05.010     Document Type: Article

References (40)

1. R.B. Arora, and C.K. Arora Hypotensive and tranquillizing activity of jatamansone (valeranone) a sesquiterpene from Nardostachys jatamansi DC K.K. Chen B. Mukerji Pharmacology of Oriental Plants 1963 Pergamon Press Oxford 51 60
2. O. Arunlakhshana, and H.O. Schild Some quantitative uses of drug antagonists British Journal of Pharmacology 14 1959 48 58
3. H.M.H. Awan Kitabul Mufradat 1990 GA Printers Lahore pp. 178-179
4. S.R. Baquar Medicinal and Poisonous Plants of Pakistan 1989 Printas Karachi p. 461
5. H. Becker, and S. Chavadeoi Valepotriate production of normal and colchicine-treated cell suspension cultures of Valeriana wallichii Journal of Natural products 48 1985 17 21
6. R. Bos, H. Hendriks, J.J.C. Scheffer, and H.J. Woerdenbag Cytotoxic potential of valerian constituents and valerian tinctures Phytomedicine 5 1998 219 225
7. C. Bounthanh, C. Bergmann, J.P. Beck, M. Hagg-Berrurier, and R. Anton Valepotriates, a new class of cytotoxic and antitumor agents Planta Medica 41 1981 21 28
8. R.E. Buckingham, T.C. Hamilton, D.R. Howlett, S. Mootoo, and C. Wilson Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat British Journal of Pharmacology 97 1989 57 64
9. A. Chevallier The Encyclopedia of Medicinal Plants 1996 Dorling Kindersley London (seen at http://www.himalayahealthcare.com/aboutayurveda/cahv. html )
10. K.W. Eickstedt, and S. Rahman Psychopharmacological activity of valepotriates Arzneimittelforschung 19 1969 316 319
11. J.R. Empfield, K. Russell, and D.A. Trainor Potassium channel openers: therapeutic possibilities Pharmaceutical News 6 1995 23 27
12. +-channels in isolated cardiac myocytes Biochemical and Biophysical Research Communications 154 1988 620 625
13. ++ in myocardium, cardiac pacemaker and vascular smooth muscle Reviews of Pharmacology and Toxicology 17 1977 149 166
14. + channel in rat ileal smooth muscle European Journal of Pharmacology 271 1994 379 386
15. A.H. Gilani Antihypertensive action of himbacine in anaesthetized cats Drug Development Research 24 1991 127 133
16. A.H. Gilani, K.H. Janbaz, A. Lateef, M. Zaman, S.R. Tariq, and H.R. Ahmed Hypotensive and spasmolytic activities of crude extract of Cyprus scariosus Archives of Pharmacal Research 17 1994 145 149
17. T.C. Hamilton, S.W. Weir, and T.H. Weston Comparison of the effects of BRL34915 and verapamil on electrical and mechanical activity in rat portal vein British Journal of Pharmacology 88 1986 103 111
18. B. Hazelhoff, T.M. Malingre, and D.K. Meijer Antispasmodic effects of valeriana compounds: an in-vivo and in-vitro study on the guinea pig ileum Archives of International Pharmacodyn Therapy 257 1982 274 287
19. P.J. Houghton The scientific basis for the reputed activity of valerian Journal of Pharmacy and Pharmacology 51 1999 505 512
20. L.D. Kapoor CRC Handbook of Ayurvedic Medicinal Plants 1990 CRC Press Boca Raton p. 330
21. H. Karaki, and G. Wiess Mini-review: Calcium release in smooth muscles Life Sciences 42 1983 111 112
22. K.I. Kishii, T. Morimoto, N. Nakajima, K. Yamazaki, M. Tsujitani, and L. Takayanagi Effects of LP-805, a novel vasorelaxant agent, a potassium channel opener, on rat thoracic aorta General Pharmacology 23 1992 347 353
23. P.D. Leathwood, and F. Chauffard Quantifying the effects of mild sedatives Journal of Psychiatry Research 17 1983 115
24. M. Marder, H. Viola, C. Wasowski, S. Fernandez, J.H. Medina, and A.C. Paladini 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacology Biochemistry and Behavior 75 2003 537 545
25. K.M. Nadkarni Indian Materia Medica 3rd ed. 1976 Popular Prakashan Bombay p. 1260-1262
26. National Research Council Guide for the Care and Use of Laboratory Animals 1996 National Academy Press Washington pp. 1-7
27. U. Quest Potassium channel openers: pharmacological and clinical aspects Fundamentals in Clinical Pharmacology 6 1992 279 293
28. +-channels Trends in Pharmacological Sciences 10 1989 431 435
29. B.H. Ron, C.A. Willis, K. Bone, and M. Morgan Herbal products: active constituents, mode of action and quality control Nutrition Research Reviews 13 2000 47 77
30. G. Rucker, J. Tautges, A. Sieck, H. Wenzl, and E. Graf Isolation and pharmacodynamic activity of the sesquiterpene valeranone from Nardostachys jatamansi DC Arzneimittelforschung 28 1978 7 13
31. H.M. Said Hamdard Pharmacopoeia of Eastern Medicine 1970 Times Press Karachi p. 53
32. R.K. Suri, and T.S. Thind Antibacterial activity of some essential oils Indian Drugs and Pharmaceuticals Industry 13 1978 25 28
33. P.W. Thies Linarin-isovalerianate, a currently unknown flavonoid from Valeriana wallichii Planta Medica 16 1968 363 371
34. T.S. Thind, and R.K. Suri In vitro antifungal efficacy of four essential oils Indian Perfume 23 1979 138 140
35. L. Tona, K. Kambu, N. Ngimbi, K. Cimanga, and A.J. Vlietinck Antiamoebic and phytochemical screening of some Congolese medicinal plants Journal of Ethnopharmacology 61 1998 57 65
36. S.V. Tripathi, S.K. Tiwari, and G.N. Chaturvedi Comparative clinical trial of certain indigenous drugs (Dhanya panchaka) in gastric secretion (hyperchlorhydria and hypochlorhydria) Nagarjun 25 1982 170 174
37. J.M. Van Rossum Cumulative dose-response curves. 11. Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters Archives of International Pharmacodyn Therapy 143 1963 299 330
38. S.B. Vohora, and P.C. Dandiya Herbal analgesic drugs Fitoterapia 63 1992 195 207
39. H. Wanger, K. Jurcic, and R. Schaette Comparative studies on the sedative action of Valeriana extracts, valepotriates and their degradation products Planta Medica 39 1980 358 365
40. A.H. Weston, and G. Edwards Recent progress in potassium channel opener pharmacology Biochemical Pharmacology 43 1992 47 54