RNA vaccines in cancer treatment

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Bringmann, Anita ^a   Held, Stefanie Andrea Erika ^a   Heine, Annkristin ^a   Brossart, Peter ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RNA VACCINE; TUMOR ANTIGEN; CANCER VACCINE; RNA;

BRAIN CANCER; CANCER IMMUNOTHERAPY; CANCER MORTALITY; COLORECTAL CANCER; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; KIDNEY CARCINOMA; LUNG ADENOCARCINOMA; MELANOMA; NEUROBLASTOMA; PANCREAS CANCER; REVIEW; VACCINATION; ANIMAL; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; NEOPLASM;

ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; DENDRITIC CELLS; HUMANS; IMMUNOTHERAPY; NEOPLASMS; RNA;

EID: 77954544704     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/623687     Document Type: Review

References (99)

1. Pilch Y. H., de Kernion J. B., Skinner D. G., Immunotherapy of cancer with immune RNA. A preliminary report The American Journal of Surgery 1976 132 5 631 637
2. Pilch Y. H., Ramming K. P., DeKernion J. B., Preliminary studies of specific immunotherapy of cancer with immune RNA Cancer 1977 40 5 2747 2757
3. Steele G. Jr., Wang B. S., Richie J., In vivo effect and parallel in vitro lymphocyte-mediated tumor cytolysis after phase I xenogeneic immune RNA treatment of patients with widespread melanoma or metastatic renal cell carcinoma Cancer Research 1980 40 7 2377 2382
4. Hoerr I., Obst R., Rammensee H.-G., Jung G., In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies European Journal of Immunology 2000 30 1 1 7
5. Weide B., Carralot J.-P., Reese A., Results of the first phase I/II clinical vaccination trial with direct injection of mRNA Journal of Immunotherapy 2008 31 2 180 188
6. van der Bruggen P., Traversari C., Chomez P., A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma Science 1991 254 5038 1643 1647
7. Coulie P. G., Brichard V., Van Pel A., A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas The Journal of Experimental Medicine 1994 180 1 35 42 (Pubitemid 24181053)
8. Caballero O. L., Chen Y.-T., Cancer/testis (CT) antigens: potential targets for immunotherapy Cancer Science 2009 100 11 2014 2021
9. Chen Y.-T., Scanlan M. J., Sahin U., A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening Proceedings of the National Academy of Sciences of the United States of America 1997 94 5 1914 1918
10. Wolfel T., Hauer M., Schneider J., A p16(INK4a)-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma Science 1995 269 5228 1281 1284
11. Fossum B., Gedde-Dahl T. III, Hansen T., Eriksen J. A., Thorsby E., Gaudernack G., Overlapping epitopes encompassing a point mutation (12Gly→Arg) in p21 ras can be recognized by HLA-DR, -DP and -DQ restricted T cells European Journal of Immunology 1993 23 10 2687 2691
12. Mandruzzato S., Brasseur F., Andry G., Boon T., Van der Bruggen P., A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma The Journal of Experimental Medicine 1997 186 5 785 793
13. Markowitz S., Wang J., Myeroff L., Inactivation of the type II TGF- receptor in colon cancer cells with microsatellite instability Science 1995 268 5215 1336 1338
14. Parsons R., Myeroff L. L., Liu B., Microsatellite instability and mutations of the transforming growth factor type II receptor gene in colorectal cancer Cancer Research 1995 55 23 5548 5550
15. Saeterdal I., Gjertsen M. K., Straten P., A TGF betaRII frameshift-mutation-derived CTL epitope recognised by HLA-A2-restricted CD8+ T cells Cancer Immunology, Immunotherapy 2001 50 469 476
16. Bakker A. B. H., Schreurs M. W. J., de Boer A. J., Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes The Journal of Experimental Medicine 1994 179 3 1005 1009
17. Brichard V., Van Pel A., Wolfel T., The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas The Journal of Experimental Medicine 1993 178 2 489 495
18. Wolfel T., Van Pel A., Brichard V., Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes European Journal of Immunology 1994 24 3 759 764 (Pubitemid 24076646)
19. Adida C., Haioun C., Gaulard P., Prognostic significance of survivin expression in diffuse large B-cell lymphomas Blood 2000 96 5 1921 1925
20. Grossman D., McNiff J. M., Li F., Altieri D. C., Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma Journal of Investigative Dermatology 1999 113 6 1076 1081
21. Schmidt S. M., Schag K., Muller M. R., Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells Blood 2003 102 2 571 576
22. Brossart P., Schneider A., Dill P., The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes Cancer Research 2001 61 18 6846 6850
23. Girling A., Bartkova J., Burchell J., Gendler S., Gillett C., Taylor-Paradimitriou J., A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas International Journal of Cancer 1989 43 6 1072 1076
24. Nair S. K., Boczkowski D., Morse M., Cumming R. I., Lyerly H. K., Gilboa E., Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA Nature Biotechnology 1998 16 4 364 369 (Pubitemid 28164657)
25. Rae F. K., Stephenson S.-A., Nicol D. L., Clements J. A., Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display International Journal of Cancer 2000 88 5 726 732
26. Schmidt S. M., Schag K., Muller M. R., Induction of adipophilin-specific cytotoxic T lymphocytes using a novel HLA-A2-binding peptide that mediates tumor cell lysis Cancer Research 2004 64 3 1164 1170
27. Yokoyama Y., Grunebach F., Schmidt S. M., Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells Clinical Cancer Research 2008 14 17 5503 5511
28. Grunebach F., Erndt S., Hantschel M., Heine A., Brossart P., Generation of antigen-specific CTL responses using RGS1 mRNA transfected dendritic cells Cancer Immunology, Immunotherapy 2008 57 10 1483 1491
29. Boss C. N., Grunebach F., Brauer K., Identification and characterization of T-cell epitopes deduced from RGS5, a novel broadly expressed tumor antigen Clinical Cancer Research 2007 13 11 3347 3355
30. Oka Y., Elisseeva O. A., Tsuboi A., Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product Immunogenetics 2000 51 2 99 107 (Pubitemid 30150969)
31. Molldrem J., Dermime S., Parker K., Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells Blood 1996 88 7 2450 2457
32. Molldrem J. J., Clave E., Jiang Y. Z., Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units Blood 1997 90 7 2529 2534
33. Greiner J., Ringhoffer M., Taniguchi M., Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia Experimental Hematology 2002 30 9 1029 1035
34. Schmidt S. M., Konig T., Bringmann A., Characterization of BAX inhibitor-1 as a novel leukemia-associated antigen Leukemia 2009 23 10 1818 1824
35. Inaba K., Turley S., Iyoda T., The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli The Journal of Experimental Medicine 2000 191 6 927 936
36. Inaba K., Witmer-Pack M., Inaba M., The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro The Journal of Experimental Medicine 1994 180 5 1849 1860
37. Caux C., Massacrier C., Vanbervliet B., Activation of human dendritic cells through CD40 cross-linking The Journal of Experimental Medicine 1994 180 4 1263 1272
38. Hart D. N., Prickett T. C., Intercellular adhesion molecule-2 (ICAM-2) expression on human dendritic cells Cellular Immunology 1993 148 447 454
39. Inaba K., Steinman R. M., Monoclonal antibodies to LFA-1 and to CD4 inhibit the mixed leukocyte reaction after the antigen-dependent clustering of dendritic cells and T lymphocytes The Journal of Experimental Medicine 1987 165 5 1403 1417
40. Prickett T. C. R., McKenzie J. L., Hart D. N. J., Adhesion molecules on human tonsil dendritic cells Transplantation 1992 53 2 483 490
41. Bevan M. J., Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay The Journal of Experimental Medicine 1976 143 1283 1288
42. Bevan M. J., Priming for a cytotoxic response to minor histocompatibility antigens: antigen specificity and failure to demonstrate a carrier effect Journal of Immunology 1977 118 4 1370 1374
43. Brossart P., Bevan M. J., Presentation of exogenous protein antigens on major histocompatability complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines Blood 1997 90 4 1594 1599
44. Caux C., Dezutter-Dambuyant C., Schmit D., Banchereau J., GM-CSF and TNF- cooperate in the generation of dendritic Langerhans cells Nature 1992 360 6401 258 261
45. Caux C., Vanbervliet B., Massacrier C., CD 34 + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF The Journal of Experimental Medicine 1996 184 2 695 706
46. Inaba K., Inaba M., Romani N., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor The Journal of Experimental Medicine 1992 176 6 1693 1702
47. Peters J. H., Xu H., Ruppert J., Ostermeier D., Friedrichs D., Gieseler R. K. H., Signals required for differentiating dendritic cells from human monocytes in vitro Advances in Experimental Medicine and Biology 1993 329 275 280
48. Romani N., Gruner S., Brang D., Proliferating dendritic cell progenitors in human blood The Journal of Experimental Medicine 1994 180 1 83 93
49. Sallusto F., Lanzavecchia A., Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor The Journal of Experimental Medicine 1994 179 4 1109 1118
50. Lee A. W., Truong T., Bickham K., A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy Vaccine 2002 20 supplement 4 A8 A22
51. Carralot J.-P., Weide B., Schoor O., Production and characterization of amplified tumor-derived cRNA libraries to be used as vaccines against metastatic melanomas Genetic Vaccines and Therapy 2005 3, article 6
52. Scheel B., Teufel R., Probst J., Toll-like receptor-dependent activation of several human blood cell types by protamine-condensed mRNA European Journal of Immunology 2005 35 5 1557 1566
53. Scheel B., Aulwurm S., Probst J., Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA European Journal of Immunology 2006 36 10 2807 2816
54. Boczkowski D., Nair S. K., Snyder D., Gilboa E., Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo The Journal of Experimental Medicine 1996 184 2 465 472 (Pubitemid 26324100)
55. Milazzo C., Reichardt V. L., Muller M. R., Grunebach F., Brossart P., Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA Blood 2003 101 3 977 982 (Pubitemid 36139369)
56. Heiser A., Maurice M. A., Yancey D. R., Coleman D. M., Dahm P., Vieweg J., Human dendritic cells transfected with renal tumor RNA stimulate polyclonal T-cell responses against antigens expressed by primary and metastatic tumors Cancer Research 2001 61 8 3388 3393
57. Grunebach F., Kayser K., Weck M. M., Muller M. R., Appel S., Brossart P., Cotransfection of dendritic cells with RNA coding for HER-2/neu and 4-1BBL increases the induction of tumor antigen specific cytotoxic T lymphocytes Cancer Gene Therapy 2005 12 9 749 756
58. Onaitis M. W., Kalady M. F., Emani S., Abdel-Wahab Z., Tyler D. S., Pruitt S. K., CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy Surgery 2003 134 2 300 305
59. Kalady M. F., Onaitis M. W., Emani S., Abdel-Wahab Z., Tyler D. S., Pruitt S. K., Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity Journal of Surgical Research 2004 116 1 24 31
60. Abdel-Wahab Z., Cisco R., Dannull J., Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses Journal of Surgical Research 2005 124 2 264 273
61. Kalady M. F., Onaitis M. W., Padilla K. M., Emani S., Tyler D. S., Pruitt S. K., Enhanced dendritic cell antigen presentation in RNA-based immunotherapy Journal of Surgical Research 2002 105 1 17 24
62. Naka T., Iwahashi M., Nakamura M., Tumor vaccine therapy against recrudescent tumor using dendritic cells simultaneously transfected with tumor RNA and granulocyte macrophage colony-stimulating factor RNA Cancer Science 2008 99 2 407 413
63. Kim S.-G., Park M.-Y., Kim C.-H., Modification of CEA with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC vaccination Vaccine 2008 26 50 6433 6440
64. Heiser A., Coleman D., Dannull J., Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors Journal of Clinical Investigation 2002 109 3 409 417
65. Morse M. A., Nair S. K., Boczkowski D., The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer International Journal of Gastrointestinal Cancer 2002 32 1 1 6
66. Bedrosian I., Mick R., Xu S., Intranodal administration of peptide-pulsed mature dendritic cell vaccines results in superior CD8+ T-cell function in melanoma patients Journal of Clinical Oncology 2003 21 20 3826 3835
67. Fong L., Brockstedt D., Benike C., Wu L., Engleman E. G., Dendritic cells injected via different routes induce immunity in cancer patients Journal of Immunology 2001 166 6 4254 4259
68. Kyte J. A., Mu L., Aamdal S., Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA Cancer Gene Therapy 2006 13 10 905 918
69. Dueland S., Mu L. J., Kvalheim G., Dendritic cells transfected with allo-tumor mRNA as cancer vaccine in treatment of hormone resistant prostate cancer patients Journal of Clinical Oncology 2005 23 16s. abstract no. 2541
70. de Vries I. J. M., Lesterhuis W. J., Barentsz J. O., Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy Nature Biotechnology 2005 23 11 1407 1413
71. Bonehill A., Van Nuffel A. M. T., Corthals J., Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients Clinical Cancer Research 2009 15 10 3366 3375
72. Su Z., Dannull J., Heiser A., Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells Cancer Research 2003 63 9 2127 2133
73. Rains N., Cannan R. J., Chen W., Stubbs R. S., Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer Hepato-Gastroenterology 2001 48 38 347 351
74. Wolff J. A., Malone R. W., Williams P., Direct gene transfer into mouse muscle in vivo Science 1990 247 4949 1465 1468
75. Qiu P., Ziegelhoffer P., Sun J., Yang N. S., Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization Gene Therapy 1996 3 3 262 268
76. Malone R. W., Felgner P. L., Verma I. M., Cationic liposome-mediated RNA transfection Proceedings of the National Academy of Sciences of the United States of America 1989 86 16 6077 6081
77. Espuelas S., Roth A., Thumann C., Frisch B., Schuber F., Effect of synthetic lipopeptides formulated in liposomes on the maturation of human dendritic cells Molecular Immunology 2005 42 6 721 729
78. Korsholm K. S., Agger E. M., Foged C., The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes Immunology 2007 121 2 216 226
79. Scheell B., Braedel S., Probst J., Immunostimulating capacities of stabilized RNA molecules European Journal of Immunology 2004 34 2 537 547
80. Carralot J.-P., Probst J., Hoerr I., Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines Cellular and Molecular Life Sciences 2004 61 18 2418 2424
81. Schmidt S. M., Haentschel M., Mueller M. R., Vaccinations with RNA coding for tumor associated antigens in advanced RCC patientsa phase I/II study Journal of Clinical Oncology 2008 16 supplement. abstract no. 3017
82. Weide B., Garbe C., Rammensee H.-G., Pascolo S., Plasmid DNA- and messenger RNA-based anti-cancer vaccination Immunology Letters 2008 115 1 33 42
83. Dannull J., Su Z., Rizzieri D., Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells Journal of Clinical Investigation 2005 115 12 3623 3633
84. Kristiansen O. P., Larsen Z. M., Pociot F., CTLA-4 in autoimmune diseasesa general susceptibility gene to autoimmunity? Genes and Immunity 2000 1 3 170 184
85. Tivol E. A., Borriello F., Schweitzer A. N., Lynch W. P., Bluestone J. A., Sharpe A. H., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity 1995 3 5 541 547
86. Waterhouse P., Penninger J. M., Timms E., Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4 Science 1995 270 5238 985 988
87. Ribas A., Camacho L. H., Lopez-Berestein G., Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206 Journal of Clinical Oncology 2005 23 35 8968 8977
88. Sutmuller R. P., van Duivenvoorde L. M., van Elsas E., Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses The Journal of Experimental Medicine 2001 194 6 823 832
89. Vollmer J., Weeratna R., Payette P., Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities European Journal of Immunology 2004 34 1 251 262 (Pubitemid 38111541)
90. Vollmer J., Krieg A. M., Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists Advanced Drug Delivery Reviews 2009 61 3 195 204
91. Molenkamp B. G., Sluijter B. J. R., Van Leeuwen P. A. M., Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients Clinical Cancer Research 2008 14 14 4532 4542
92. Hipp M. M., Hilf N., Walter S., Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses Blood 2008 111 12 5610 5620
93. Nair S. K., Morse M., Boczkowski D., Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells Annals of Surgery 2002 235 4 540 549
94. Morse M. A., Nair S. K., Mosca P. J., Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA Cancer Investigation 2003 21 3 341 349
95. Caruso D. A., Orme L. M., Neale A. M., Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer Neuro-Oncology 2004 6 3 236 246
96. Caruso D. A., Orme L. M., Amor G. M., Results of a phase I study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children with stage 4 neuroblastoma Cancer 2005 103 6 1280 1291
97. Su Z., Dannull J., Yang B. K., Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer Journal of Immunology 2005 174 6 3798 3807
98. Mu L. J., Kyte J. A., Kvalheim G., Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients British Journal of Cancer 2005 93 7 749 756
99. Weide B., Pascolo S., Scheel B., Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients Journal of Immunotherapy 2009 32 5 498 507