Dominant-negative VDAC1 mutants reveal oligomeric VDAC1 to be the active unit in mitochondria-mediated apoptosis

Biochemical Journal

Volumn 429, Issue 1, 2010, Pages 147-155

  Mader, Asaf ^a   Abu Hamad, Salah ^a   Arbel, Nir ^a   Gutierr Suilar, Manuel ^b   Shoshan Barmatz, Varda ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Apoptosis; Dominant negative effect; Mitochondrion; Ruthenium Red (RUR); Voltage dependent anion channel 1 (VDAC1); Voltage dependent anion channel 1 (VDAC1) oligomerization

Indexed keywords

293 CELLS; ANTI-APOPTOTIC EFFECTS; APOPTOSIS; APOPTOTIC CELL DEATH; APOPTOTIC PROCESS; BI-LAYER; FUSION PROTEINS; IN-CELL; INDUCED APOPTOSIS; INTERMOLECULAR INTERACTIONS; MITOCHONDRIAL PROTEIN; OVER-EXPRESSION; STAUROSPORINES; VOLTAGE-DEPENDENT ANION CHANNEL 1 (VDAC1); VOLTAGE-DEPENDENT ANION CHANNELS; WILD TYPES;

CLOUDS; IONS; MITOCHONDRIA; MONOMERS; OLIGOMERIZATION; PLANTS (BOTANY); PROTEINS; RUTHENIUM;

CELL DEATH;

HYBRID PROTEIN; MONOMER; OLIGOMER; RUTHENIUM RED; STAUROSPORINE; VOLTAGE DEPENDENT ANION CHANNEL 1; VDAC1 PROTEIN, RAT;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CROSS LINKING; HUMAN; HUMAN CELL; MEMBRANE CONDUCTANCE; MITOCHONDRION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL LINE; COMPARATIVE STUDY; DOMINANT GENE; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN BINDING; RAT;

RATTUS;

ANIMALS; APOPTOSIS; CELL LINE; GENES, DOMINANT; HUMANS; MITOCHONDRIA; MUTATION; PROTEIN BINDING; RATS; RECOMBINANT FUSION PROTEINS; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 77954516857     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091338     Document Type: Article

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