High prevalence of non-organ-specific autoantibodies in hepatitis C virus-infected cirrhotic patients from southern Italy

Digestive Diseases and Sciences

Volumn 48, Issue 2, 2003, Pages 349-353

  Squadrito, Giovanni ^a   Previti, Marcello ^a   Lenzi, Marco ^b   Le Rose, Enrico Pagano ^a   Caccamo, Gaia ^a   Restuccia, Tea ^a   Di Cesare, Enrico ^a   Pollicino, Teresa ^a   Raimondo, Giovanni ^a,c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Anti liver kidney microsomes type 1 antibodies; Anti mitochondrial antibodies; Anti nuclear antibodies; Anti smooth muscle antibodies; Hepatitis C virus; Indirect immunofluorescence

Indexed keywords

AUTOANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS C ANTIBODY; NON ORGAN SPECIFIC AUTOANTIBODY; UNCLASSIFIED DRUG; VIRUS RNA;

ADULT; AGED; AGING; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENOTYPE; HEPATITIS C; HUMAN; IMMUNOFLUORESCENCE; ITALY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE GENETICS; RNA ANALYSIS; SEX DIFFERENCE; VIRUS LOAD;

ADULT; AGE DISTRIBUTION; AGED; AUTOANTIBODIES; BIOPSY, NEEDLE; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; HEPATITIS C ANTIBODIES; HEPATITIS C, CHRONIC; HUMANS; ITALY; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; PREVALENCE; PROBABILITY; REFERENCE VALUES; RISK ASSESSMENT; SEROEPIDEMIOLOGIC STUDIES; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION;

EID: 0037326574     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021991813586     Document Type: Article

References (42)

1. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M: Isolation of a cDNA clone derived froma blood-borne non-A non-B viral hepatitis genome. Science 244:359-362, 1989
2. Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, Myamura T, Dienstag JL, Alter MJ, Stevens CE: An assay for circulating antibodies antibodies to a major etiologic virus of human non-A non-B hepatitis. Science 244:362-364, 1989
3. Clarke B: Molecular virology of hepatitis C virus J Gen Virol 78:2397-2410, 1997
4. Board VHP: Global surveillance and control of hepatitis C. J Viral Hepatitis 6:35-47, 1999
5. Alberti A, Chemello L, Benvegnù L: Natural history of hepatitis C. J Hepatol 31:(suppl 1): 17-24, 1999
6. Liang TJ, Rehermann B, Seef LB, Hoofnagle JH: Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann Intern Med 132:296-305, 2000
7. Alter MJ, Margolis HS, Krawczynski K, Judson FN, Mares A, Alexander WJ, Gerber MA, Sampliner RE: The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A non-B Hepatitis Study Team. N Engl J Med 327:1899-1905, 1992
8. Saho I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo Q, Houghton M, Kuo G: Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 87:6547-6549, 1990
9. Pagliaro L, Peri V, Linea C, Cammà C, Giunta M, Magrin S: Natural history of chronic hepatitis C. Ital J Gastroenterol Hepatol 31:28-44, 1999
10. McHutchison JG, Gordon SC, Schiff ER, Schiffmann ML, Lee WM, Rustgi VK, Goodmann ZD, Ling MH, Cort S, Albrecht JK: Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 339(21): 1485-1492, 1998
11. Poynard T, Marcellin P, Lee SS, Niederau C, Minuk GS, Ideo G, Bain V, Heathcote J, Zeuzem S, Trepo C, Albrecht J: Randomised trial of interferon alpha2b plus ribvirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group. Lancet 352:1426-1432, 1998
12. Zeuzem S, Feinman SV, Rasenack J, Heathcote EJ, Lay MY, Gane E, O'Grady J, Reichen J, Diago M, Lin A, Hoffman J, Brunda MJ: PEG-interferon alfa-2a in patients with chronic hepatitis C. N Engl J Med 343(23):1666-1672, 2000
13. Heathcote EJ, Shiffman ML, Cooksley WG, Dusheiko GM, Lee SS, Balart L, Reindollar R, Reddy RK, Wright TL, Lin A, Hoffman J, De Pamphilis J: PEG-interferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med 343(23): 1673-80, 2000
14. Lindsay KL, Trepo C, Heintges T, Shiffman ML, Gordon SC, Hoefs JC, Schiff ER, Goodman ZD, Laughlin M, Yao R, Albrecht JK: A randomized, double-blind trial comparing PEGylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C. Hepatology 34:395-403, 2001
15. Czaja AJ, Hamburger HA: Autoantibodies in liver disease. Gastroenterology I20:239-249, 2001
16. Obermarmayer-Straub P, Manns MP: Hepatitis C and D, retroviruses and autoimmune manifestations. J Autoimmun 16:275-285, 2001
17. Lunel F, Musset L, Franjeul L, Cresta P, Perrin M, Grippon P, Hoang C, Valla D, Piette JC: Cryoglobulinemia in chronic liver disease: role of hepatitis C virus and liver damage. Gastroenterology 106:1291-1300, 1994
18. Adinolfi LE, Utili R, Attanasio V, Zampino R, Ragone E, Tripodi MF, Ruggiero G: Epidemiology, clinical spectrum and prognostic value of mixed cryoglobulinemia in hepatitis C virus patients. A prospective study. Ital J Gastroenterol 28:1-9, 1996
19. Wong VS, Egner W, Elsey T, Brown D, Alexander GJ: Incidence, character and clinical relevance of mixed cryoglobulinemia in patients with chronic hepatitis C virus infection. Clin Exp Immunol 109:25-31, 1996
20. Nagasaka A, Takahashi T, Sasaki T, Takimoto K, Miyashita K, Nakamura M, Wakahama O, Nishikawa S, Higuchi A: Cryoglobulinemia in Japanese patients with chronic hepatitis C virus infection: host genetic and virological study. J Med Virol 65:52-57, 2001
21. Johnson JR, Gretch DR, Yamabe H, Hart J, Bacchi CE, Hartwell P, Couser WG, Corey L, Wener MH, Alpers CE: Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 328:465-470, 1993
22. Tran A, Quaranta JF, Benzaken S, Triers V, Chau HT, Hastier P, Regnier D, Dreyfus G, Pradier C, Sadoul JL: High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapy. Hepatology 18:253-257, 1993
23. Lenzi M, Johnson PJ, Mcfarlane IG, Ballardini G, Smith HM, McFarlane BM, Bridger C, Vergani D, Bianchi FB, Williams R: Antibodies to hepatitis C virus in autoimmune liver disease: evidence for geographical heterogeneity. Lancet 277-280, 1991
24. Cassani F, Muratori L, Manotti P, Lenzi M, Fusconi M, Ballardini G, Selleri L, Volta U, Zauli D, Maniero R, Bianchi FB: Serum autoantibodies and the diagnosis of type-1 autoimmune hepatitis in Italy: a reappraisal at the light of hepatitis C virus infection. Gut 33:1260-1263, 1992
25. Abuaf N, Lunel F, Giral P, Borotto E, Laperche S, Poupon R, Opolon P, Huraux JM, Homberg JC: Non-organ specific autoantibodies associated with chronic C virus hepatitis. J Hepatol 18:359-364, 1993
26. Fried MW, Draguesku JO, Shindo M, Simpson LH, Banks SM, Hoofnagle JH, Di Bisceglie AM: Clinical and serological differentiation of autoimmune and hepatitis C virus-related chronic hepatitis. Dig Dis Sci 38:631-636, 1993
27. Clifford BD, Donahue D, Smith L, Cable E, Luttig B, Manns M, Bonkovsky HL: High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C. Hepatology 21:613-619, 1995
28. Meyer zum Buschenfelde KH, Lohse AW, Gerken G, Treichel U, Lohr HF, Mohr H, Grosse A, Dienes HP: The role of autoimmunity in hepatitis C infection. J Hepatol 22:(suppl 1):93-96, 1995
29. Czaja AJ, Carpenter HA, Santrach PJ, Santrach PJ, Moore SB, Taswell HF, Homburger HA: Evidence against hepatitis viruses as important causes of severe autoimmune hepatitis in the United States. J Hepatol 18:342-352, 1993
30. Reddy KR, Krawitt EL, Homberg JC, Jeffers LJ, de Medina M, Chastenay B, Poupon R, Opolon P, Beaugrand M, Abuaf N: Absence of LKM1 antibody in hepatitis C viral infection in the United States. J Viral Hepatitis 2:175-179, 1995
31. Lunel F, Abuaf N, Frangeul L, Grippon P, Perrin M, Le Coz Y, Valla D, Borotto E, Yamamoto AM, Huraux JM, Opolon P, Homberg JC: Liver/kidney microsome antibody type 1 and hepatitis c virus infection. Hepatology 16:630-636, 1992
32. Czaja AJ, Manns MP, Homburger HA: Frequency and significance of antibodies to liver/kidney microsome type 1 in adult with chronic hepatitis. Gastroenterology 103:1290-1295, 1992
33. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB: Immunological features and HLA association in chronic viral hepatitis. Gastroenterology 108:157-164, 1995
34. Muratori L, Lenzi M, Cataleta M, Giostra F, Cassani F, Ballardini G, Zauli D, Bianchi FB: Interferon therapy in liver kidney microsomal antibody type 1-positive patients with chronic hepatitis C. J Hepatol 21:199-203, 1994
35. Lenzi M, Bellentani S, Saccoccio G, Muratori P, Masutti F, Muratori L, Cassani F, Bianchi FB, Tiribelli C: Prevalence of non-organ-specific autoantibodies and chronic liver disease in the general population: a nested case-control study of the Dionysos cohort. Gut 45:435-441, 1999
36. Cassani F, Cataleta M, Valentini P, Muratori P, Giostra F, Francesconi R, Muratori L, Lenzi M, Bianchi G, Zauli D, Bianchi FB: Serum autoantibodies in chronic hepatitis c: comparison with autoimmune hepatitis and impact on the disease profile. Hepatology 26:561-566, 1997
37. Czaja AJ, Carpenter HA: Histological findings in chronic hepatitis C with autoimmune features. Hepatology 26:459-466, 1997
38. Pawlotsky JM, Ben Yahia M, Andrè C, Voisin MC, Intrator L, Roudot-Thoraval F, Deforges L, Duvoux C, Zafrani ES, Duval J: Immunological disorders in C virus chronic active hepatitis: a prospective case-control study. Hepatology 19:841-848, 1994
39. Pietrangelo A, Montosi G, Totaro A, Garuti C, Conte D, Cassanelli S, Fraquelli M, Sandini C, Vasta F, Gasparini P: Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene. N Engl J Med. 341(10):725-732, 1999
40. Campo S, Restuccia T, Raffa G, Cucinotta D, Squadrito G, Pollicino T, Raimondo G: Analysis of haemochromatosis gene mutations in a population from the Mediterranean Basin. Liver 21:233-236, 2001
41. Squadrito G, Leone F, Sartori M, Nalpas B, Berthelot P, Raimondo G, Pol S, Brèchot C: Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alpha. Gastroenterology 113:567-572, 1997
42. Czaja AJ, Manns MP, Homburger AH: Frequency and significance of autoantibodies to liver/kidney microsome type 1 in adults with chronic hepatitis. Gastroenterology 103:1290-1295, 1992