메뉴 건너뛰기




Volumn 49, Issue 2, 2010, Pages 271-280

X-irradiation-induced cell cycle delay and DNA double-strand breaks in the murine osteoblastic cell line OCT-1

Author keywords

[No Author keywords available]

Indexed keywords

BONE CELLS; CELL CYCLE; CELL-CYCLE ARREST; CELLULAR RESPONSE; DOSE DEPENDENCY; DOSE-DEPENDENT; DOUBLE-STRAND BREAKS; GENE EXPRESSION PROFILES; GROWTH FACTOR; HUMAN BONES; MATRIX FORMATION; OSTEOBLAST DIFFERENTIATION; OSTEOBLAST-LIKE CELLS; OSTEOBLASTIC CELLS; OSTEOBLASTIC DIFFERENTIATION; OSTEOGENIC; PROPIDIUM IODIDE; Q-RT-PCR; RADIATION RESPONSE; RADIATION-INDUCED; REGULATORY PROTEIN; REVERSE TRANSCRIPTION PCR; TRANSFORMING GROWTH FACTOR BETA; X-IRRADIATION;

EID: 77954458715     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-010-0272-6     Document Type: Article
Times cited : (29)

References (54)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-2196
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 0035341209 scopus 로고    scopus 로고
    • TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
    • Alliston T, Choy L, Ducy P, Karsenty G et al (2001) TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 20:2254-2272
    • (2001) EMBO J. , vol.20 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4
  • 3
    • 0029031653 scopus 로고
    • Radiation-induced impairment of osseus healing quantitatives studies using a standard drilling defect in rat femur
    • Arnold M, Kummermehr J, Trott KR (1995) Radiation-induced impairment of osseus healing quantitatives studies using a standard drilling defect in rat femur. Radiat Res 143:77-84
    • (1995) Radiat. Res. , vol.143 , pp. 77-84
    • Arnold, M.1    Kummermehr, J.2    Trott, K.R.3
  • 4
    • 0032323828 scopus 로고    scopus 로고
    • Advances in the osteoblast lineage
    • Aubin JE (1998) Advances in the osteoblast lineage. Biochem Cell Biol 76:899-910
    • (1998) Biochem. Cell. Biol. , vol.76 , pp. 899-910
    • Aubin, J.E.1
  • 5
    • 0029129229 scopus 로고
    • Osteoblast and chondroblast differentiation
    • Aubin JE, Liu F, Malaval L, Gupta AK (1995) Osteoblast and chondroblast differentiation. Bone 17(2 Suppl):77-83
    • (1995) Bone , vol.17 , Issue.2 SUPPL. , pp. 77-83
    • Aubin, J.E.1    Liu, F.2    Malaval, L.3    Gupta, A.K.4
  • 6
    • 24044528421 scopus 로고    scopus 로고
    • Mechanics and mechanobiology of fracture healing in normal and osteoporotic bone
    • Augat P, Simon U, Liedert A, Claes L (2005) Mechanics and mechanobiology of fracture healing in normal and osteoporotic bone. Osteoporos Int 16(Suppl 2):36-43
    • (2005) Osteoporos Int. , vol.16 , Issue.2 SUPPL. , pp. 36-43
    • Augat, P.1    Simon, U.2    Liedert, A.3    Claes, L.4
  • 7
    • 0033367321 scopus 로고    scopus 로고
    • Regulation and regulatory activities of transforming growth factor beta
    • Bonewald LF (1999) Regulation and regulatory activities of transforming growth factor beta. Crit Rev Eukaryot Gene Expr 9:33-44
    • (1999) Crit. Rev. Eukaryot Gene Expr , vol.9 , pp. 33-44
    • Bonewald, L.F.1
  • 8
    • 0028888762 scopus 로고
    • Osteoblastic cell lines derived from a transgenic mouse containing the osteocalcin promotor driving SV40 T anitgen
    • Chen D, Chen H, Feng JQ, Windle JJ et al (1995) Osteoblastic cell lines derived from a transgenic mouse containing the osteocalcin promotor driving SV40 T anitgen. Molec Cell Differ 3:193-212
    • (1995) Molec Cell. Differ , vol.3 , pp. 193-212
    • Chen, D.1    Chen, H.2    Feng, J.Q.3    Windle, J.J.4
  • 9
    • 0027181746 scopus 로고
    • Kinetics of in vitro mineralization by an osteogenic clonal cell line (C1) derived from mouse teratocarcinoma
    • Chentoufi J, Hott M, Lamblin D, Buc-Caron MH et al (1993) Kinetics of in vitro mineralization by an osteogenic clonal cell line (C1) derived from mouse teratocarcinoma. Differentiation 53:181-189
    • (1993) Differentiation , vol.53 , pp. 181-189
    • Chentoufi, J.1    Hott, M.2    Lamblin, D.3    Buc-Caron, M.H.4
  • 10
    • 0035163845 scopus 로고    scopus 로고
    • Transcriptional regulation and function during the human cell cycle
    • Cho RJ, Huang M, Campbell MJ, Dong H et al (2001) Transcriptional regulation and function during the human cell cycle. Nat Genet 27:48-54
    • (2001) Nat. Genet. , vol.27 , pp. 48-54
    • Cho, R.J.1    Huang, M.2    Campbell, M.J.3    Dong, H.4
  • 11
    • 0003125639 scopus 로고    scopus 로고
    • Growth Factors
    • Seibel MJ, Robins SP, Bilezikian JP eds, Academic Press, San Diego
    • Croucher PI, Russell RG (1999) Growth Factors. In: Seibel MJ, Robins SP, Bilezikian JP (eds) Dynamics of bone and cartilage metabolism. Academic Press, San Diego, pp 453-464
    • (1999) Dynamics of Bone and Cartilage Metabolism , pp. 453-464
    • Croucher, P.I.1    Russell, R.G.2
  • 12
    • 0031067717 scopus 로고    scopus 로고
    • Effects of ionizing radiation on proliferation and differentiation of osteoblast-like cells
    • Dare A, Hachisu R, Yamaguchi A, Yokose S et al (1997) Effects of ionizing radiation on proliferation and differentiation of osteoblast-like cells. J Dent Res 76:658-664
    • (1997) J. Dent. Res. , vol.76 , pp. 658-664
    • Dare, A.1    Hachisu, R.2    Yamaguchi, A.3    Yokose, S.4
  • 13
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffrey V, Ridall AL et al (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754
    • (1997) Cell. , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffrey, V.3    Ridall, A.L.4
  • 16
    • 33644975004 scopus 로고    scopus 로고
    • RNA integrity and the effect on the realtime qRT-PCR performance
    • Fleige S, Pfaffel MW (2006) RNA integrity and the effect on the realtime qRT-PCR performance. Mol Aspects Med 27:126-139
    • (2006) Mol. Aspects Med. , vol.27 , pp. 126-139
    • Fleige, S.1    Pfaffel, M.W.2
  • 17
    • 0035021561 scopus 로고    scopus 로고
    • Changes of fibrosis-related parameters after high-and low-LET irradiation of fibroblasts
    • Fournier C, Scholz M, Weyrather WK, Rodemann HP et al (2001) Changes of fibrosis-related parameters after high-and low-LET irradiation of fibroblasts. Int J Radiat Biol 77:713-722
    • (2001) Int. J. Radiat. Biol. , vol.77 , pp. 713-722
    • Fournier, C.1    Scholz, M.2    Weyrather, W.K.3    Rodemann, H.P.4
  • 18
    • 0026034165 scopus 로고
    • Effects of radiation therapy on skeletal growth in childhood
    • Goldwein JW (1991) Effects of radiation therapy on skeletal growth in childhood. Clin Orthop Relat Res 262:101-107
    • (1991) Clin. Orthop. Relat. Res. , vol.262 , pp. 101-107
    • Goldwein, J.W.1
  • 19
    • 0033548440 scopus 로고    scopus 로고
    • Cbfa1 isoforms exert functional differences in osteoblast differentiation
    • Harada H, Tagashira S, Fujiwara M, Ogawa S et al (1999) Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 274:6972-6978
    • (1999) J. Biol. Chem. , vol.274 , pp. 6972-6978
    • Harada, H.1    Tagashira, S.2    Fujiwara, M.3    Ogawa, S.4
  • 20
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614-636
    • (1965) Exp. Cell. Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 21
    • 0033789360 scopus 로고    scopus 로고
    • Spontaneous and radiation-induced differentiation of fibroblasts
    • Herskind C, Rodemann HP (2000) Spontaneous and radiation-induced differentiation of fibroblasts. Exp Gerontol 35:747-755
    • (2000) Exp. Gerontol. , vol.35 , pp. 747-755
    • Herskind, C.1    Rodemann, H.P.2
  • 22
    • 0033883519 scopus 로고    scopus 로고
    • Fibroblast differentiation in subcutaneous fibrosis after postmastectomy radiotherapy
    • Herskind C, Johansen J, Bentzen SM, Overgaard M et al (2000) Fibroblast differentiation in subcutaneous fibrosis after postmastectomy radiotherapy. Acta Oncol 39:383-388
    • (2000) Acta Oncol. , vol.39 , pp. 383-388
    • Herskind, C.1    Johansen, J.2    Bentzen, S.M.3    Overgaard, M.4
  • 23
    • 0042844493 scopus 로고    scopus 로고
    • Radiation-therapy effects on bone density
    • Hopewell JW (2003) Radiation-therapy effects on bone density. Med Pediatr Ocol 41:208-211
    • (2003) Med. Pediatr. Ocol , vol.41 , pp. 208-211
    • Hopewell, J.W.1
  • 26
    • 84907106124 scopus 로고
    • Proviked reptitives healing of mature bone tissue following irradiation. A quantitative investigation
    • Jacobsson M, Kälebo P, Albrektsson T, Turesson L (1986) Proviked reptitives healing of mature bone tissue following irradiation. A quantitative investigation. Acta Radiol Ocol 25:57-62
    • (1986) Acta Radiol. Ocol , vol.25 , pp. 57-62
    • Jacobsson, M.1    Kälebo, P.2    Albrektsson, T.3    Turesson, L.4
  • 27
    • 33746871738 scopus 로고    scopus 로고
    • Transforming growth factor beta 1, bone connection
    • Kanaan RA, Kanaan LA (2006) Transforming growth factor beta 1, bone connection. Med Sci Monit 12:164-169
    • (2006) Med. Sci. Monit. , vol.12 , pp. 164-169
    • Kanaan, R.A.1    Kanaan, L.A.2
  • 28
    • 0035831510 scopus 로고    scopus 로고
    • Cbfa1 contributes to the osteoblast specific expression of type I collagen genes
    • Kern B, Shen J, Starbuck M, Karsenty G (2001) Cbfa1 contributes to the osteoblast specific expression of type I collagen genes. J Biol Chem 276:7101-7107
    • (2001) J. Biol. Chem. , vol.276 , pp. 7101-7107
    • Kern, B.1    Shen, J.2    Starbuck, M.3    Karsenty, G.4
  • 29
    • 33751197049 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation by transcription factors
    • Komori T (2006) Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99:1233-1239
    • (2006) J. Cell. Biochem. , vol.99 , pp. 1233-1239
    • Komori, T.1
  • 30
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T, Yagi H, Nomura S, Yamaguchi A et al (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764
    • (1997) Cell. , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4
  • 31
    • 0037343809 scopus 로고    scopus 로고
    • Polymorphism in the transforming growth factor beta 1 gene and osteoporosis
    • Langdahl BL, Carstens M, Stenkjaer L, Eriksen EF (2003) Polymorphism in the transforming growth factor beta 1 gene and osteoporosis. Bone 32:297-310
    • (2003) Bone , vol.32 , pp. 297-310
    • Langdahl, B.L.1    Carstens, M.2    Stenkjaer, L.3    Eriksen, E.F.4
  • 32
    • 0038727503 scopus 로고    scopus 로고
    • Premature keratinocyte death and expression of marker proteins of apoptosis in human skin after UVB exposure
    • Mass P, Hoffmann K, Gambichler T, Altmeyer P et al (2003) Premature keratinocyte death and expression of marker proteins of apoptosis in human skin after UVB exposure. Arch Dermatol Res 295:71-79
    • (2003) Arch. Dermatol. Res. , vol.295 , pp. 71-79
    • Mass, P.1    Hoffmann, K.2    Gambichler, T.3    Altmeyer, P.4
  • 33
    • 33847643776 scopus 로고    scopus 로고
    • Quantification of mRNA using real-time RT-PCR
    • Nolan T, Hands RE, Bustin SA (2006) Quantification of mRNA using real-time RT-PCR. Nat Protec 1(3):1559-1582
    • (2006) Nat. Protec , vol.1 , Issue.3 , pp. 1559-1582
    • Nolan, T.1    Hands, R.E.2    Bustin, S.A.3
  • 34
    • 0030666372 scopus 로고    scopus 로고
    • Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • Otto F, Thornell AP, Crompton T, Denzel A et al (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771
    • (1997) Cell. , vol.89 , pp. 765-771
    • Otto, F.1    Thornell, A.P.2    Crompton, T.3    Denzel, A.4
  • 35
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • doi:10.1093/nar/29.9.e45
    • Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acids Res 29: e45. doi:10.1093/nar/29.9.e45
    • (2001) Nucl. Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 36
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • doi:10.1093/nar/30.9.e36
    • Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucl Acids Res 30 (9): e36. doi:10.1093/nar/30.9.e36
    • (2002) Nucl. Acids Res. , vol.30 , Issue.9
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 37
    • 1842483281 scopus 로고    scopus 로고
    • Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: Bestkeeper-Excel-based tool using pair-wise correlations
    • Pfaffl MW, Tichopad A, Prgomet C, Neuvians TP (2004) Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations. Biotechnol Lett 26(6):509-515
    • (2004) Biotechnol. Lett. , vol.26 , Issue.6 , pp. 509-515
    • Pfaffl, M.W.1    Tichopad, A.2    Prgomet, C.3    Neuvians, T.P.4
  • 38
    • 0016424846 scopus 로고
    • The effects of radiation therapy on bone growth
    • Probert JC, Parker BR (1975) The effects of radiation therapy on bone growth. Radiology 114:155-162
    • (1975) Radiology , vol.114 , pp. 155-162
    • Probert, J.C.1    Parker, B.R.2
  • 39
    • 0002129975 scopus 로고    scopus 로고
    • Quantification of the light cycler
    • Meuer S, Wittwer C, Nakagawara K eds, Springer, Heidelberg, ISBN 3-540-66736-9
    • Rasmussen R (2001) Quantification of the light cycler. In: Meuer S, Wittwer C, Nakagawara K (eds) Rapid cycle real-time PCR, methods and applications. Springer, Heidelberg, ISBN 3-540-66736-9:21-34
    • (2001) Rapid Cycle Real-time PCR, Methods and Applications , pp. 21-34
    • Rasmussen, R.1
  • 40
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta)
    • Roberts AB, Sporn MB (1993) Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 8:1-9
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 41
    • 0024534983 scopus 로고
    • Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro
    • Rodemann HP, Bayreuther K, Francz PI, Dittmann K et al (1989) Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro. Exp Cell Res 180:84-93
    • (1989) Exp. Cell. Res. , vol.180 , pp. 84-93
    • Rodemann, H.P.1    Bayreuther, K.2    Francz, P.I.3    Dittmann, K.4
  • 42
    • 0032489520 scopus 로고    scopus 로고
    • DNA doublestranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS et al (1998) DNA doublestranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273:5858-5868
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4
  • 43
    • 0036676638 scopus 로고    scopus 로고
    • Misrepair of radiation-induced DNA double-strand breaks and its relevance for tumorgenesis and cancer treatment (review)
    • Rothkamm K, Löbrich M (2002) Misrepair of radiation-induced DNA double-strand breaks and its relevance for tumorgenesis and cancer treatment (review). Int J Oncol 21:433-440
    • (2002) Int. J. Oncol. , vol.21 , pp. 433-440
    • Rothkamm, K.1    Löbrich, M.2
  • 44
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA doublestrand break repair in human cells exposed to very low X-ray doses
    • Rothkamm K, Löbrich M (2003) Evidence for a lack of DNA doublestrand break repair in human cells exposed to very low X-ray doses. Proc Nat Acad Sci USA 100:5057-5062
    • (2003) Proc. Nat. Acad. Sci. USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Löbrich, M.2
  • 45
    • 0014001171 scopus 로고
    • The effect of 2000 r of X-rays on the acid and alkaline phosphatase of mouse tibiae
    • Sams A (1965) The effect of 2000 r of X-rays on the acid and alkaline phosphatase of mouse tibiae. Int J Radiat Biol Relat Stud Phys Chem Med 10:123-140
    • (1965) Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. , vol.10 , pp. 123-140
    • Sams, A.1
  • 46
    • 0035991249 scopus 로고    scopus 로고
    • Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells
    • Sowa H, Kaji H, Yamaguchi T, Sugimoto T et al (2002) Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J Bone Miner Res 17:1190-1199
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1190-1199
    • Sowa, H.1    Kaji, H.2    Yamaguchi, T.3    Sugimoto, T.4
  • 47
    • 0027321842 scopus 로고
    • Molecular mechanism mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype
    • Stein GS, Lian JB (1993) Molecular mechanism mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14:424-442
    • (1993) Endocr Rev. , vol.14 , pp. 424-442
    • Stein, G.S.1    Lian, J.B.2
  • 48
    • 1542615159 scopus 로고    scopus 로고
    • Decimal point-osteoporosis therapy at the 10-year mark
    • Strewler GJ (2004) Decimal point-osteoporosis therapy at the 10-year mark. N Engl J Med 350:1172-1174
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1172-1174
    • Strewler, G.J.1
  • 49
    • 0035219571 scopus 로고    scopus 로고
    • Radiationinduced senescence-like growth arrest requires TP53 function but not telomere shortening
    • Suzuki K, Mori I, Nakayama Y, Miyakoda M et al (2001) Radiationinduced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiat Res 155:248-253
    • (2001) Radiat. Res. , vol.155 , pp. 248-253
    • Suzuki, K.1    Mori, I.2    Nakayama, Y.3    Miyakoda, M.4
  • 50
    • 0942278943 scopus 로고    scopus 로고
    • Ionizing radiation sensitizes bone cells to apoptosis
    • Szymczyk KH, Shapiro IM, Adams CS (2004) Ionizing radiation sensitizes bone cells to apoptosis. Bone 34:148-156
    • (2004) Bone , vol.34 , pp. 148-156
    • Szymczyk, K.H.1    Shapiro, I.M.2    Adams, C.S.3
  • 51
    • 0014711349 scopus 로고
    • Changes in the proliferative activity of young and old mouse skeletal tissues following Co60 whole-body irradiation
    • Tonna EA, Pavelec M (1970) Changes in the proliferative activity of young and old mouse skeletal tissues following Co60 whole-body irradiation. J Gerontol 25:9-16
    • (1970) J. Gerontol. , vol.25 , pp. 9-16
    • Tonna, E.A.1    Pavelec, M.2
  • 52
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitaive RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele J, De Preter K, Pattyn F, Poppe B et al (2002) Accurate normalization of real-time quantitaive RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:34
    • (2002) Genome Biol. , vol.3 , pp. 34
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4
  • 53
    • 34247527312 scopus 로고    scopus 로고
    • Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage
    • Zhou T, Chou J, Mullen TE, Elkon R et al (2007) Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage. Cell Cycle 6:972-981
    • (2007) Cell. Cycle , vol.6 , pp. 972-981
    • Zhou, T.1    Chou, J.2    Mullen, T.E.3    Elkon, R.4
  • 54
    • 0041396065 scopus 로고    scopus 로고
    • In vitro differentiation of embryonic stem cells into mineralized osteoblasts
    • zur Nieden NI, Kempka G, Ahr HJ (2003) In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 71:18-27
    • (2003) Differentiation , vol.71 , pp. 18-27
    • Kempka, G.1    Ahr, H.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.